Dendritic Cell Vaccination in Patients With Advanced Melanoma

PHASE1CompletedINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

May 1, 2017

Primary Completion Date

March 31, 2023

Study Completion Date

March 31, 2023

Conditions
Melanoma
Interventions
BIOLOGICAL

Mature dendritic cell (DC) vaccine

Mature DC 7.5-15 million/peptide followed by 2 booster every six weeks of 1-5 million/peptide followed by standard of care anti PD-1 therapy.

DRUG

Cyclophosphamide 300mg/m^2

administered prior to subject's first DC dose

DRUG

Pembrolizumab

administered 7-8 weeks after subject's last DC dose

Trial Locations (1)

19104

University of Pennsylvania, Philadelphia

All Listed Sponsors
lead

University of Pennsylvania

OTHER

NCT03092453 - Dendritic Cell Vaccination in Patients With Advanced Melanoma | Biotech Hunter | Biotech Hunter