340
Participants
Start Date
November 16, 2017
Primary Completion Date
June 30, 2025
Study Completion Date
December 31, 2025
Afatinib
Afatinib 40 mg given orally, once daily, 1 cycle is 28 days
Palbociclib
Palbociclib 125 mg given orally, once daily, 1 cycle is 28 days (21 days on treatment, then 7 days off)
standard of care
Methotrexate, Paclitaxel, Docetaxel, Carboplatin, 5-Fluorouracil, Bleomycine, Gemcitabine, Mitomycine or Best supportive care
IPH2201
protocol v2.0 and 2.1 : Monalizumab 10mg/kg given intravenously over 60 minutes, once every 14 days, 1 cycle is 14 days protocol v4.0 : Monalizumab 750mg given intravenously over 60 minutes, once every 28 days, 1 cycle is 28 days
Durvalumab
Durvalumab 1500mg given intravenously over 60 minutes, once every 28 days, 1 cycle is 28 days
Niraparib
Niraparib 300 mg given orally, once daily, 1 cycle is 28 days
INCAGN01876
INCAGN01876 300 mg given intravenously over 30 minutes, once every 14 days, 1 cycle is 28 days
CHU Saint-Pierre-Site Porte de Hal, Brussels
U.Z. Leuven - Campus Gasthuisberg, Leuven
Hospital Universitario 12 De Octubre, Madrid
Hospital Clinico Universitario De Valencia, Valencia
Azienda Ospedaliero-Universitaria Careggi, Florence
Centre Oscar Lambret, Lille
Institut de Cancerologie Strasbourg Europe, Strasbourg
IRCCS - Fondazione G. Pascale, Napoli
Cliniques Universitaires Saint-Luc, Brussels
Hopitaux Universitaires Bordet-Erasme - Institut Jules Bordet, Brussels
Grand Hopital de Charleroi - Grand Hôpital de Charleroi - Site Notre Dame, Charleroi
Universitair Ziekenhuis Antwerpen, Edegem
Universitair Ziekenhuis Gent, Ghent
Hopital De Jolimont, Haine-Saint-Paul
AZ Groeninge Kortrijk - Campus Kennedylaan, Kortrijk
U.Z. Leuven - Campus Gasthuisberg, Leuven
GasthuisZusters Antwerpen - Sint-Augustinus, Wilrijk
CHU Dinant Godinne - UCL Namur, Yvoir
CHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre, Bordeaux
Centre Georges-Francois-Leclerc, Dijon
Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau, Nantes
Centre Antoine Lacassagne, Nice
Institut Curie, Paris
Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy
Gustave Roussy, Villejuif
Azienda Ospedaliero-Universitaria Careggi, Florence
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
"Istituto Nazionale Tumori IRCCS Fondazione G. Pascale", Napoli
University Hospitals Birmingham NHS Foundation Trust (UHB) - UHB-Queen Elisabeth Medical Centre, Birmingham
NHS Lothian - Western General Hospital, Edinburgh
NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital, Glasgow
Guy's and St Thomas' NHS - Guy s and St Thomas' NHS - Guy's Hospital, London
Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital, Sheffield
ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia), Barcelona
NHS Lothian - Western General Hospital, Edinburgh
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK