A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs

PHASE3CompletedINTERVENTIONAL
Enrollment

657

Participants

Timeline

Start Date

May 9, 2017

Primary Completion Date

June 13, 2019

Study Completion Date

June 6, 2023

Conditions
Rheumatoid Arthritis (RA)
Interventions
DRUG

Abatacept

IV infusion

DRUG

Placebo for abatacept (0.9% Sodium Chloride Injection or Solution for Infusion)

IV infusion

DRUG

Upadacitinib

15 mg extended release tablet

DRUG

Placebo for upadacitinib

Film-coated tablet

Trial Locations (161)

1023

Budai Irgalmasrendi Korhaz /ID# 154457, Budapest

1036

Obudai Egeszsegugyi Centrum Kft. /ID# 156159, Budapest

1038

Riga East Clinical Univ Hosp /ID# 155024, Riga

1046

Aprillus Asistencia e Investig /ID# 159173, Capital Federal

1205

Hopitaux Universitaires de Geneve /ID# 159083, Geneva

1417

Ctr Privado Med Familiar /ID# 158814, Buenos Aires

1428

Inst. de Rehab. Psicofisica /ID# 167768, CABA

1505

Diag Consult Ctr 17 Sofia EOOD /ID# 169298, Sofia

1612

UMHAT Sv. Ivan Rilski /ID# 155000, Sofia

1704

DIM Clinica Privada /ID# 167769, Ramos Mejía

1708

HFR Fribourg - Hopital Canton /ID# 160970, Fribourg

1784

Medical Centre Synexus Sofia /ID# 201807, Sofia

3011

Western Health Footscray Hospi /ID# 157968, Footscray

3300

Markhot Ferenc Oktatokorhaz es Rendelointezet /ID# 159689, Eger

3401

D.Saulites-Kandevicas PP /ID# 154578, Liepāja

4000

MHAT Trimontsium /ID# 155226, Plovdiv

4031

Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 159183, Debrecen

University Hospital of Basel /ID# 160860, Basel

4558

Rheumatology Research Unit /ID# 159174, Maroochydore

5000

Inst. Rheumatologic Strusberg /ID# 159021, Córdoba

CHU UCL Namur /ID# 157628, Namur

MAV Korhaz ess Rendelointezet /ID# 154455, Szolnok

5011

The Queen Elizabeth Hospital /ID# 159175, Woodville

6021

Wellington Hospital (Capital and Coast District Health Board) /ID# 154591, Wellington

6100

Ankara Univ Medical Faculty /ID# 162691, Ankara

7910

Timaru Medical Specialists Ltd /ID# 159184, Timaru

9007

Kantonsspital St. Gallen /ID# 155232, Sankt Gallen

10126

AOU Citta della Salute Scienza /ID# 154577, Turin

11554

NYU Langone Rheum Assoc /ID# 155236, Lake Success

11650

Centro Especializado en Diabetes, Obesidad y Prevención de Enfermedades Cardiova /ID# 160126, Mexico City

11850

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 154579, Mexico City

12163

Praxis fuer Rheumatologie /ID# 156156, Berlin

12206

The Center for Rheumatology /ID# 162979, Albany

14004

Hospital Universitario Reina S /ID# 155701, Córdoba

15260

University of Pittsburgh MC /ID# 157434, Pittsburgh

15706

Complejo Hospitalario /ID# 155700, Santiago de Compostela

16635

Altoona Ctr Clinical Res /ID# 154572, Duncansville

18015

East Penn Rheumatology Assoc /ID# 159193, Bethlehem

20089

Istituto Clinico Humanitas /ID# 154999, Rozzano

20095

Rheumaforschungszentrum II /ID# 157177, Hamburg

20122

ASST G. Pini /ID# 162223, Milan

20902

The Center for Rheumatology & Bone Research /ID# 158723, Wheaton

27834

Physicians East, PA /ID# 154565, Greenville

28046

Hospital Universitario La Paz /ID# 163636, Madrid

28144

PMG Research of Salisbury /ID# 154605, Salisbury

28401

PMG Research of Wilmington LLC /ID# 154584, Wilmington

30033

Jefrey D. Lieberman, MD, P.C. /ID# 157178, Decatur

32514

Gulf Region Clinical Res Inst /ID# 154597, Pensacola

33321

W. Broward Rheum Assoc Inc. /ID# 158835, Tamarac

33765

Clinical Res of West FL, Inc. /ID# 154576, Clearwater

34147

Istanbul Fizik Tedavi Rehabilitasyon Egitim ve Arastırma Hastanesi /ID# 169479, Istanbul

34292

Lovelace Scientific Resources /ID# 154600, Venice

37000

Morales Vargas Centro de Investigacion S.C. /ID# 200800, León

38305

West Tennessee Research Inst /ID# 158721, Jackson

40515

Bluegrass Community Research /ID# 154604, Lexington

41010

Hospital Infanta Luisa /ID# 154641, Seville

42003

Four Rivers Clinical Research /ID# 154606, Paducah

44160

Centro Integral en Reumatología S.A de C.V /ID# 204493, Guadalajara

44281

Meir Medical Center /ID# 162774, Kfar Saba

48910

Advanced Rheumatology, PC /ID# 154589, Lansing

49546

West Michigan Rheumatology /ID# 154551, Grand Rapids

50937

Uniklinik Koln /ID# 156047, Cologne

60126

A.O. Univ. Ospedali Riuniti /ID# 161707, Ancona

61820

PMG Research of Christie Clini /ID# 154569, Champaign

71110

"University General Hospital of Heraklion PA.G.N.I /ID# 163916", Heraklion

72189

Vastmanlands Sjukhus /ID# 159186, Västerås

77375

DM Clinical Research /ID# 158722, Tomball

78278

Barzilai Medical Center /ID# 161685, Ashkelon

78404

Adriana Pop-Moody MD Clinic PA /ID# 154607, Corpus Christi

80228

Scientia Medical Research /ID# 159189, Lakewood

80230

Denver Arthritis Clinic /ID# 159195, Denver

80528

Arthritis and Rheum Clin N. CO /ID# 155673, Fort Collins

82152

Welcker, Planegg, DE /ID# 160185, Planegg

82606

Univerzitna Nemocnica Bratislava /ID# 161143, Bratislava

83642

Advanced Clinical Research /ID# 154603, Meridian

85351

AZ Arthritis & Rheum Research /ID# 156539, Sun City

85381

SunValley Arthritis Center, Lt /ID# 154558, Peoria

85704

AZ Arth & Rheum Res /ID# 167161, Tucson

88011

Arthritis and Osteo Assoc /ID# 154560, Las Cruces

91942

Kotha and Kotha /ID# 154573, La Mesa

92835

Saint Jude Heritage /ID# 158833, Fullerton

95123

Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele /ID# 161172, Catania

97239

Oregon Health and Science University /ID# 163822, Portland

97405

Novamed,spol.s.r.o. /ID# 157928, Banská Bystrica

121374

State Budget Healthcare Instit /ID# 154593, Moscow

141060

Family Outpatient clinic#4 LLC /ID# 203524, Korolev

191015

Nort-Western State Medical Uni /ID# 154610, Saint Petersburg

426061

Alliance Biomedical Ural Group /ID# 154609, Izhevsk

630099

LLC Medical Center /ID# 203523, Novosibirsk

3436212

The Lady Davis Carmel MC /ID# 161686, Haifa

5262100

Sheba Medical Center /ID# 163154, Ramat Gan

71913-6999

CHI St. Vincent Medical Group /ID# 154561, Hot Springs

34761-4547

Advanced Clin Res of Orlando /ID# 154580, Ocoee

70836-6455

Ochsner Clinic Foundation /ID# 154585, Baton Rouge

65810-2607

Clinvest Research LLC /ID# 154554, Springfield

07901-3561

Overlook Medical Center /ID# 154794, Summit

08755

Atlantic Coast Research /ID# 155234, Toms River

Ocean Rheumatology, PA /ID# 162980, Toms River

10016-6402

NYU Langone Medical Center /ID# 158829, New York

27157-0001

Wake Forest Baptist Medical Center /ID# 154586, Winston-Salem

75904-3132

P&I Clinical Research /ID# 159191, Lufkin

84124-1377

Care Access Research /ID# 158098, Salt Lake City

1426AAL

Atencion Integral en Reuma /ID# 155696, Buenos Aires

C1221ADC

Hospital General de Agudos /ID# 167117, Buenos Aires

X5003DCE

Instituto Medico DAMIC /ID# 167770, Córdoba

S2000PBJ

Instituto CAICI SRL /ID# 159022, Rosario, Santa FE

29055-450

CEDOES-Centro de Diagnóstico e Pesquisa da Osteoporose do Espírito Santo LTDA /ID# 155228, Vitória

30150-221

Santa Casa de Belo Horizonte /ID# 154631, Belo Horizonte

36010-570

CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 154564, Juiz de Fora

80030-110

Ceti - Centro de Estudos Em Terapias Inovadoras Ltda /Id# 154634, Curitiba

90035-903

Hospital de Clinicas de Porto Alegre /ID# 161211, Porto Alegre

90480-000

LMK Sevicos Medicos S/S /ID# 159176, Porto Alegre

09190-510

CEMEC - Centro Multidisciplinar de Estudos Clínicos /ID# 154632, Santo André

04266-010

CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos Ltda /ID# 159587, São Paulo

L4M 6L2

The Waterside Clinic /ID# 159178, Barrie

L8N 1Y2

Adachi Medicine Prof. Corp /ID# 158024, Hamilton

H2L 1S6

Institut de Rhum. de Montreal /ID# 155001, Montreal

G1V 3M7

Groupe de Recherche en Maladies Osseuses /ID# 154601, Sainte-Foy

128 00

Revmatologicky ustav Praha /ID# 154612, Prague

686 01

Medical Plus, s.r.o. /ID# 155230, Uherské Hradište

Unknown

Our Lady's Hospital /ID# 161149, Manorhamilton

Lancashire Care NHS Foundation /ID# 156042, Preston

00168

Presidio Columbus, Fondazione Policlinico Gemelli Universita Cattolica S. Cuore /ID# 162252, Rome

03100

RM Pharma Specialists S.A de C.V /ID# 159588, Mexico City

8601 ZK

Antonius Ziekenhuis /ID# 155737, Sneek

1056 AB

Reade /ID# 161002, Amsterdam

2035 RC

Spaarne Gasthuis /ID# 161003, Haarlem

8934 AD

Medisch Centrum Leeuwarden /ID# 156043, Leeuwarden

60-218

Medyczne Centrum Hetmanska /ID# 155746, Poznan

30-149

Malopolskie Centrum Kliniczne /ID# 157180, Krakow

03-291

Centrum Medyczne AMED Warszawa Targowek /ID# 159589, Warsaw

15-099

Gabinet Internistyczno Reum. /ID# 157433, Bialystok

15-879

ClinicMed Daniluk, Nowak Sp.j. /ID# 202998, Bialystok

81-537

Synexus Polska Sp. z o.o. Oddzial w Gdyni /ID# 202472, Gdynia

91-363

Centrum Med Amed Oddzial Lodzi /ID# 154458, Lodz

91-211

Salve Medica Sp. z o.o. S.K. /ID# 202473, Lodz

1050-034

Instituto Portugues De Reumatologia /ID# 155698, Lisbon

1349-019

Centro Hospitalar Lisboa Ocidental, EPE /ID# 200035, Lisbon

2805-267

Hospital Garcia de Orta, E.P.E /ID# 164056, Almada

1649-035

Centro Hospitalar Lisboa Norte, EPE /ID# 200037, Lisbon

4901-858

Unidade Local De Saude Do Alto Minho /ID# 200036, Viana do Castelo

3504-509

Centro Hosp de Tondela-Viseu /ID# 155699, Viseu

00983

Dr. Ramon L. Ortega-Colon, MD /ID# 158097, Carolina

00909

GCM Medical Group /ID# 156158, San Juan

020475

Spitalul Clinic Dr. I. Cantacuzino /ID# 155893, Bucharest

011172

Spitalul Clinic Sf. Maria /ID# 167245, Bucharest

921 12

Narodny ustav reumatickych chorob Piestany /ID# 156864, Pieštany

07061

SMG-SNU Boramae Medical Center /ID# 155788, Seoul

07345

The Catholic University of Korea, Yeouido St. Mary's Hospital /ID# 155231, Seoul

05505

Asan Medical Center /ID# 154639, Seoul

03202

Hospital General Univ de Elche /ID# 158825, Elche

08208

Corp Sanitaria Parc Tauli /ID# 163634, Sabadell, Barcelona

214 28

Skanes Universitetssjukhus /ID# 165133, Malmo

113 65

Akademiskt specialistcentrum Centrum for reumatologi /ID# 156046, Stockholm

413 45

Sahlgrenska University Hosp /ID# 162775, Gothenburg

06100

Hacettepe University Medical Faculty /ID# 167995, Ankara

Akdeniz University Faculty /ID# 163153, Antalya

E11 1NR

Whipps Cross Univ Hospital /ID# 205985, London

DD1 9SY

Ninewells Hospital /ID# 156050, Dundee

BT47 6SB

Altnagelvin Area Hospital /ID# 156540, Londonderry

TR1 3LJ

Royal Cornwall Hospital /ID# 157785, Truro

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