867
Participants
Start Date
June 5, 2017
Primary Completion Date
March 31, 2020
Study Completion Date
December 16, 2022
MEDI4736 (Durvalumab)
A human monoclonal antibody (mAb) of the immunoglobulin G (IgG) 1 kappa subclass that blocks the interaction of PD-L1 (but not programmed cell death ligand-2) with PD-1 on T cells and CD80 (B7.1) on immune cells (IC).
MEDI4736 (Durvalumab) + Tremelimumab
"Durvalumab: A human mAb of IgG 1 kappa subclass that blocks the interaction of PD-L1 (but not programmed cell death ligand-2) with PD-1 on T cells and CD80 (B7.1) on IC.~Tremelimumab: A human Ig G2 mAb that completely blocks the interaction of human CTLA-4 (cluster of differentiation \[CD\]152) with CD80 and CD86 and increase release of cytokines (interleukin \[IL\]-2 and interferon \[IFN\]-γ) from human T cells, peripheral blood mononuclear cells and whole blood."
Research Site, Nice
Research Site, Goyang-si
Research Site, East Setauket
Research Site, Marseille
Research Site, Berlin
Research Site, Washington D.C.
Research Site, Rozzano
Research Site, Milan
Research Site, Hamburg
Research Site, Dijon
Research Site, Blacksburg
Research Site, Kiel
Research Site, Besançon
Research Site, Greenville
Research Site, Brest
Research Site, Nîmes
Research Site, Toulouse
Research Site, Bordeaux
Research Site, Bordeaux
Research Site, Udine
Research Site, Gütersloh
Research Site, Bielefeld
Research Site, Montpellier
Research Site, Padua
Research Site, Tours
Research Site, Knoxville
Research Site, Modena
Research Site, Saint-Herblain
Research Site, Essen
Research Site, Meldola
Research Site, Duisburg
Research Site, Ravenna
Research Site, Münster
Research Site, Busan
Research Site, Arezzo
Research Site, Pisa
Research Site, Lille
Research Site, Ancona
Research Site, Tinley Park
Research Site, Strasbourg
Research Site, Omaha
Research Site, Lyon
Research Site, Pierre-Bénite
Research Site, Bari
Research Site, Stuttgart
Research Site, Lecce
Research Site, Paris
Research Site, Rouen
Research Site, Avellino
Research Site, Poitiers
Research Site, Erlangen
Research Site, Villejuif
Research Site, Catania
Research Site, Santa Rosa
Research Site, Würzburg
Research Site, Spokane
Research Site, Hackensack
Research Site, Moncton
Research Site, Brampton
Research Site, Hamilton
Research Site, Kingston
Research Site, London
Research Site, Newmarket
Research Site, Toronto
Research Site, Toronto
Research Site, Greenfield Park
Research Site, Québec
Research Site, Dresden
Research Site, Jena
Research Site, Roma
Research Site, Roma
Research Site, Leiden
Research Site, Seoul
Research Site, Seoul
Research Site, London
Research Site, London
Research Site, London
Research Site, Newcastle
Research Site, Sheffield
Lead Sponsor
AstraZeneca
INDUSTRY