Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus

PHASE1CompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

April 18, 2017

Primary Completion Date

June 5, 2017

Study Completion Date

June 30, 2017

Conditions
Venous ThromboembolismPharmacokineticsHealthy
Interventions
DRUG

Apixaban alone

A single dose of 10 mg apixaban administered orally at 0H on Day 1.

DRUG

Cyclosporine

Once daily dose of 100 mg cyclosporine administered orally on Days 1 to 3.

DRUG

Tacrolimus

Once daily dose of 5 mg tacrolimus administered orally on Days 1 to 3.

DRUG

Apixaban

A single dose of 10 mg apixaban administered orally on Day 3 immediately following cyclosporine

DRUG

Apixaban

A single dose of 10 mg apixaban administered orally on Day 3 immediately following tacrolimus

Trial Locations (1)

19107

Thomas Jefferson University, Philadelphia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Thomas Jefferson University

OTHER