Adjuvant Ribociclib With Endocrine Therapy in Hormone Receptor+/HER2- High Risk Early Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

June 20, 2017

Primary Completion Date

March 9, 2020

Study Completion Date

March 9, 2020

Conditions
Breast Cancer
Interventions
DRUG

Ribociclib

"Ribociclib 600 mg daily on days 1 to 21 of a 28-day cycle for 26 cycles (approximately 24 months).~Ribociclib was supplied in the form of 200 mg film-coated tablets taken by mouth."

DRUG

Adjuvant endocrine therapy

Letrozole 2.5 mg by mouth daily, or anastrozole 1 mg by mouth daily, exemestane 25 mg by mouth daily, tamoxifen 20 mg by mouth daily, for a total duration of at least 60 months. In premenopausal women, a GnRH agonist administered every 28 days.

DRUG

Placebo

"Placebo 600 mg daily on days 1 to 21 of a 28-day cycle for 26 cycles (approximately 24 months).~Placebo was supplied in the form of 200 mg film-coated tablets taken by mouth."

Trial Locations (33)

11042

Pro Health Care Associates, New Hyde Park

20904

Maryland Oncology Hematology P A, Silver Spring

22031

Fairfax Northern Virginia Hem/Onc, Fairfax

28210

The Presbyterian Hospital, Charlotte

30342

Northside Hospital Central Research Dept., Atlanta

31405

Summit Cancer Care, PC, Savannah

33021

Memorial Regional Hospital, Hollywood

33705

Florida Cancer Specialists - North Florida Cancer Specialist N, St. Petersburg

33916

Florida Cancer Specialists South Region, Fort Myers

34952

Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie

37203

SCRI - Tennessee Oncology, Nashville

37404

Tennessee Oncology, PLLC, Chattanooga

38138

The West Clinic, Germantown

64111

Saint Luke's Hospital of Kansas City, Kansas City

66209

Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Div., Leawood

72703

Highlands Oncology Group, Fayetteville

75246

Baylor Charles A. Sammons Cancer Center, Dallas

75251

Texas Oncology P A Texas Oncology - Houston, Dallas

75702

Texas Oncology PA - Tyler, Tyler

77090

Millennium Oncology, Houston

78258

Cancer Care Network of South Texas, San Antonio

80218

Rocky Mountain Cancer Centers Regulatory, Denver

85704

Arizona Oncology Associates PC- HAL, Tucson

90024

University of California - Los Angeles, Los Angeles

90277

TRIO - Torrance Health Association, Redondo Beach

90603

Innovative Clinical Research Institute, Whittier

93030

Ventura County Hematology and Oncology, Oxnard

93309

CBCC Global Research, Bakersfield

98405

Multicare Institute for Research and Innovation, Tacoma

Northwest Medical Specialties, Tacoma

98801

Wenatchee Valley Hospital and Clinics, Wenatchee

06360

Eastern Connecticut Hematology and Oncology Associates, Norwich

07039

Saint Barnabas Medical Center 2nd Floor East Wing, Livingston

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY