612
Participants
Start Date
April 5, 2017
Primary Completion Date
May 31, 2026
Study Completion Date
May 31, 2026
Bicalutamide
Given orally (PO)
Degarelix
Given IM
Docetaxel
Given IV
External Beam Radiation Therapy
Undergo external beam radiation therapy
Flutamide
Given PO
Goserelin
Given IM
Goserelin Acetate
Given IM
Laboratory Biomarker Analysis
Correlative studies
Leuprolide
Given intramuscularly (IM)
Leuprolide Acetate
Given IM
Nilutamide
Drug
Dickstein Cancer Treatment Center, White Plains
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn
Stony Brook University Medical Center, Stony Brook
Roswell Park Cancer Institute, Buffalo
Highland Hospital, Rochester
University of Rochester, Rochester
Jefferson Hospital, Jefferson Hills
Wexford Health and Wellness Pavilion, Wexford
Forbes Hospital, Monroeville
Allegheny General Hospital, Pittsburgh
Saint Vincent Hospital, Erie
Lewistown Hospital, Lewistown
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
Geisinger Medical Center, Danville
Geisinger Medical Oncology-Lewisburg, Lewisburg
Northeast Radiation Oncology Center, Dunmore
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
Jefferson Abington Hospital, Abington
Crozer-Keystone Regional Cancer Center at Broomall, Broomall
Saint Mary Medical and Regional Cancer Center, Langhorne
Asplundh Cancer Pavilion, Willow Grove
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Jefferson Torresdale Hospital, Philadelphia
Temple University Hospital, Philadelphia
Christiana Care Health System-Concord Health Center, Chadds Ford
Crozer Regional Cancer Center at Brinton Lake, Glen Mills
Penn State Health Saint Joseph Medical Center, Reading
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Christiana Care Health System-Christiana Hospital, Newark
Beebe South Coastal Health Campus, Millville
Beebe Health Campus, Rehoboth Beach
Central Maryland Radiation Oncology in Howard County, Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
University of Maryland/Greenebaum Cancer Center, Baltimore
TidalHealth Peninsula Regional, Salisbury
TidalHealth Richard A Henson Cancer Institute, Ocean Pines
University of Virginia Cancer Center, Charlottesville
West Virginia University Charleston Division, Charleston
Camden Clark Medical Center, Parkersburg
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
Cone Health Cancer Center, Greensboro
Duke University Medical Center, Durham
Margaret R Pardee Memorial Hospital, Hendersonville
Spartanburg Medical Center, Spartanburg
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Medical University of South Carolina, Charleston
Carolina Regional Cancer Center, Myrtle Beach
Prisma Health Cancer Institute - Faris, Greenville
Saint Francis Cancer Center, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Self Regional Healthcare, Greenwood
Prisma Health Cancer Institute - Greer, Greer
Gibbs Cancer Center-Pelham, Greer
Prisma Health Cancer Institute - Seneca, Seneca
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island
Piedmont Fayette Hospital, Fayetteville
Grady Health System, Atlanta
Emory University Hospital Midtown, Atlanta
Piedmont Hospital, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
AdventHealth Orlando, Orlando
GenesisCare USA - Key West, Key West
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Mount Sinai Medical Center, Miami Beach
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
GenesisCare USA - Aventura FP, Aventura
GenesisCare USA - Aventura, Aventura
Mount Sinai Comprehensive Cancer Center at Aventura, Aventura
GenesisCare USA - Plantation, Plantation
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
Lakeland Regional Health Hollis Cancer Center, Lakeland
GenesisCare USA - Lakewood Ranch, Lakewood Rch
AdventHealth Kissimmee, Kissimmee
AdventHealth Celebration, Celebration
Mobile Infirmary Medical Center, Mobile
University of Mississippi Medical Center, Jackson
Ohio State University Comprehensive Cancer Center, Columbus
ProMedica Flower Hospital, Sylvania
University of Toledo, Toledo
Geauga Hospital, Chardon
Mercy Cancer Center-Elyria, Elyria
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
University Hospitals Parma Medical Center, Parma
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
UHHS-Westlake Medical Center, Westlake
University Hospitals Portage Medical Center, Ravenna
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky
Miami Valley Hospital North, Dayton
Springfield Regional Cancer Center, Springfield
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
Goshen Center for Cancer Care, Goshen
Parkview Hospital Randallia, Fort Wayne
Parkview Regional Medical Center, Fort Wayne
Reid Health, Richmond
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
McLaren Cancer Institute-Macomb, Mount Clemens
Michigan Healthcare Professionals Macomb, Macomb
McLaren-Port Huron, Port Huron
Michigan Healthcare Professionals Madison Heights, Madison Heights
Corewell Health William Beaumont University Hospital, Royal Oak
Corewell Health Beaumont Troy Hospital, Troy
Henry Ford Health Warren Hospital, Warren
Michigan Healthcare Professionals Troy, Troy
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Corewell Health Dearborn Hospital, Dearborn
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Henry Ford Cancer Institute-Downriver, Brownstown
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford Health Saint John Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Michigan Healthcare Professionals Farmington, Farmington Hills
Weisberg Cancer Treatment Center, Farmington Hills
Michigan Healthcare Professionals Pontiac, Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
McLaren Cancer Institute-Clarkston, Clarkston
Michigan Healthcare Professionals Clarkston, Clarkston
McLaren Cancer Institute-Lapeer Region, Lapeer
McLaren Cancer Institute-Flint, Flint
MyMichigan Medical Center Saginaw, Saginaw
McLaren Cancer Institute-Central Michigan, Mount Pleasant
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing
Mid-Michigan Physicians-Lansing, Lansing
University of Michigan Health - Sparrow Lansing, Lansing
West Michigan Cancer Center, Kalamazoo
Allegiance Health, Jackson
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
McLaren Cancer Institute-Northern Michigan, Petoskey
McFarland Clinic - Ames, Ames
Mercy Hospital, Cedar Rapids
Aurora Cancer Care-Grafton, Grafton
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek
Froedtert Menomonee Falls Hospital, Menomonee Falls
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend
Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon
Aurora Cancer Care-Kenosha South, Kenosha
Drexel Town Square Health Center, Oak Creek
Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Zablocki Veterans Administration Medical Center, Milwaukee
Aurora Bay Area Medical Group-Marinette, Marinette
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Aspirus Regional Cancer Center, Wausau
Langlade Hospital and Cancer Center, Antigo
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids
Marshfield Medical Center - Minocqua, Minocqua
Marshfield Medical Center-EC Cancer Center, Eau Claire
Marshfield Medical Center-Rice Lake, Rice Lake
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
ThedaCare Regional Cancer Center, Appleton
Regions Hospital, Saint Paul
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Fairview Southdale Hospital, Edina
Saint Luke's Hospital of Duluth, Duluth
Mayo Clinic in Rochester, Rochester
Mayo Clinic Health Systems-Mankato, Mankato
Mayo Clinic Health System in Albert Lea, Albert Lea
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
Sanford Joe Lueken Cancer Center, Bemidji
Avera Cancer Institute, Sioux Falls
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Bozeman Health Deaconess Hospital, Bozeman
Logan Health Medical Center, Kalispell
Elmhurst Memorial Hospital, Elmhurst
Loyola University Medical Center, Maywood
Ingalls Memorial Hospital, Harvey
Edward Hospital/Cancer Center, Naperville
Edward Hospital/Cancer Center?Plainfield, Plainfield
Northwestern University, Chicago
Rush University Medical Center, Chicago
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare-Peoria, Peoria
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria
Methodist Medical Center of Illinois, Peoria
OSF Saint Francis Medical Center, Peoria
Illinois CancerCare-Bloomington, Bloomington
Alton Memorial Hospital, Alton
Illinois CancerCare-Carthage, Carthage
Crossroads Cancer Center, Effingham
Decatur Memorial Hospital, Decatur
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Saint Francis Medical Center, Cape Girardeau
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
The University of Kansas Cancer Center-South, Kansas City
University of Kansas Cancer Center - North, Kansas City
Heartland Regional Medical Center, Saint Joseph
Phelps Health Delbert Day Cancer Institute, Rolla
Mercy Hospital Springfield, Springfield
The University of Kansas Cancer Center - Olathe, Olathe
University of Kansas Cancer Center, Kansas City
University of Kansas Cancer Center-Overland Park, Overland Park
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka
Ascension Via Christi Hospitals Wichita, Wichita
Nebraska Methodist Hospital, Omaha
East Jefferson General Hospital, Metairie
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie
Ochsner Medical Center Jefferson, New Orleans
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro
University of Oklahoma Health Sciences Center, Oklahoma City
Cancer Centers of Southwest Oklahoma Research, Lawton
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
UTMB Cancer Center at Victory Lakes, League City
UCHealth University of Colorado Hospital, Aurora
Poudre Valley Hospital, Fort Collins
Penrose-Saint Francis Healthcare, Colorado Springs
UCHealth Memorial Hospital Central, Colorado Springs
Saint Alphonsus Cancer Care Center-Boise, Boise
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
LDS Hospital, Salt Lake City
Logan Regional Hospital, Logan
McKay-Dee Hospital Center, Ogden
Sandra L Maxwell Cancer Center, Cedar City
Saint George Regional Medical Center, St. George
Cancer Center at Saint Joseph's, Phoenix
University of Arizona Cancer Center-Orange Grove Campus, Tucson
Banner University Medical Center - Tucson, Tucson
University of Arizona Cancer Center-North Campus, Tucson
Radiation Oncology Centers of Nevada Central, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
UC San Diego Moores Cancer Center, La Jolla
Naval Medical Center -San Diego, San Diego
Fresno Cancer Center, Fresno
Kaiser Permanente-Fresno, Fresno
Kaiser Permanente-Redwood City, Redwood City
Kaiser Permanente Cancer Treatment Center, South San Francisco
Kaiser Permanente-South San Francisco, South San Francisco
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
Kaiser Permanente-San Francisco, San Francisco
Kaiser Permanente-Deer Valley Medical Center, Antioch
Kaiser Permanente-Fremont, Fremont
Kaiser Permanente Dublin, Dublin
Kaiser Permanente San Leandro, San Leandro
Kaiser Permanente-Vallejo, Vallejo
Sutter Solano Medical Center/Cancer Center, Vallejo
Kaiser Permanente-Walnut Creek, Walnut Creek
Kaiser Permanente Oakland-Broadway, Oakland
Kaiser Permanente-Oakland, Oakland
Kaiser Permanente-Richmond, Richmond
Kaiser Permanente-San Rafael, San Rafael
Kaiser San Rafael-Gallinas, San Rafael
Rohnert Park Cancer Center, Rohnert Park
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Kaiser Permanente-Santa Teresa-San Jose, San Jose
Kaiser Permanente-Stockton, Stockton
Kaiser Permanente-Modesto, Modesto
Kaiser Permanente-Santa Rosa, Santa Rosa
Kaiser Permanente-Roseville, Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova
The Permanente Medical Group-Roseville Radiation Oncology, Roseville
Kaiser Permanente Medical Center-Vacaville, Vacaville
Sutter Medical Center Sacramento, Sacramento
Kaiser Permanente-South Sacramento, Sacramento
South Sacramento Cancer Center, Sacramento
Kaiser Permanente Sacramento Medical Center, Sacramento
Adventist Health Cancer Care Center Chico, Chico
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee
Clackamas Radiation Oncology Center, Clackamas
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
MultiCare Auburn Medical Center, Auburn
Fairbanks Memorial Hospital, Fairbanks
Boston Medical Center, Boston
Lahey Hospital and Medical Center, Burlington
Lahey Medical Center-Peabody, Peabody
Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
AtlantiCare Health Park-Cape May Court House, Cape May Court House
AtlantiCare Surgery Center, Egg Harbor
Robert Wood Johnson University Hospital Somerset, Somerville
Atrium Medical Center-Middletown Regional Hospital, Franklin
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Texas Medical Branch, Galveston
Southwestern Vermont Medical Center, Bennington
Dartmouth Cancer Center - North, Saint Johnsbury
Arthur J E Child Comprehensive Cancer Centre, Calgary
Centro Comprensivo de Cancer de UPR, San Juan
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER