Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

612

Participants

Timeline

Start Date

April 5, 2017

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2026

Conditions
Stage I Prostate Adenocarcinoma AJCC v7Stage II Prostate Adenocarcinoma AJCC v7Stage III Prostate Adenocarcinoma AJCC v7
Interventions
DRUG

Bicalutamide

Given orally (PO)

DRUG

Degarelix

Given IM

DRUG

Docetaxel

Given IV

RADIATION

External Beam Radiation Therapy

Undergo external beam radiation therapy

DRUG

Flutamide

Given PO

DRUG

Goserelin

Given IM

DRUG

Goserelin Acetate

Given IM

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Leuprolide

Given intramuscularly (IM)

DRUG

Leuprolide Acetate

Given IM

DRUG

Nilutamide

Drug

Trial Locations (313)

10601

Dickstein Cancer Treatment Center, White Plains

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11794

Stony Brook University Medical Center, Stony Brook

14263

Roswell Park Cancer Institute, Buffalo

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

15025

Jefferson Hospital, Jefferson Hills

15090

Wexford Health and Wellness Pavilion, Wexford

15146

Forbes Hospital, Monroeville

15212

Allegheny General Hospital, Pittsburgh

16544

Saint Vincent Hospital, Erie

17044

Lewistown Hospital, Lewistown

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

18512

Northeast Radiation Oncology Center, Dunmore

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19001

Jefferson Abington Hospital, Abington

19008

Crozer-Keystone Regional Cancer Center at Broomall, Broomall

19047

Saint Mary Medical and Regional Cancer Center, Langhorne

19090

Asplundh Cancer Pavilion, Willow Grove

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19114

Jefferson Torresdale Hospital, Philadelphia

19140

Temple University Hospital, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19342

Crozer Regional Cancer Center at Brinton Lake, Glen Mills

19605

Penn State Health Saint Joseph Medical Center, Reading

19611

Reading Hospital, West Reading

19713

Helen F Graham Cancer Center, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19967

Beebe South Coastal Health Campus, Millville

19971

Beebe Health Campus, Rehoboth Beach

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21801

TidalHealth Peninsula Regional, Salisbury

21811

TidalHealth Richard A Henson Cancer Institute, Ocean Pines

22908

University of Virginia Cancer Center, Charlottesville

25304

West Virginia University Charleston Division, Charleston

26101

Camden Clark Medical Center, Parkersburg

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27403

Cone Health Cancer Center, Greensboro

27710

Duke University Medical Center, Durham

28791

Margaret R Pardee Memorial Hospital, Hendersonville

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

Medical University of South Carolina, Charleston

29577

Carolina Regional Cancer Center, Myrtle Beach

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29646

Self Regional Healthcare, Greenwood

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

29926

The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island

30214

Piedmont Fayette Hospital, Fayetteville

30303

Grady Health System, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30309

Piedmont Hospital, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

32803

AdventHealth Orlando, Orlando

33040

GenesisCare USA - Key West, Key West

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33140

Mount Sinai Medical Center, Miami Beach

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

GenesisCare USA - Aventura FP, Aventura

GenesisCare USA - Aventura, Aventura

Mount Sinai Comprehensive Cancer Center at Aventura, Aventura

33324

GenesisCare USA - Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33805

Lakeland Regional Health Hollis Cancer Center, Lakeland

34202

GenesisCare USA - Lakewood Ranch, Lakewood Rch

34744

AdventHealth Kissimmee, Kissimmee

34747

AdventHealth Celebration, Celebration

36607

Mobile Infirmary Medical Center, Mobile

39216

University of Mississippi Medical Center, Jackson

43210

Ohio State University Comprehensive Cancer Center, Columbus

43560

ProMedica Flower Hospital, Sylvania

43614

University of Toledo, Toledo

44024

Geauga Hospital, Chardon

44035

Mercy Cancer Center-Elyria, Elyria

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44145

UHHS-Westlake Medical Center, Westlake

44266

University Hospitals Portage Medical Center, Ravenna

44870

UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky

45415

Miami Valley Hospital North, Dayton

45504

Springfield Regional Cancer Center, Springfield

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46526

Goshen Center for Cancer Care, Goshen

46805

Parkview Hospital Randallia, Fort Wayne

46845

Parkview Regional Medical Center, Fort Wayne

47374

Reid Health, Richmond

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48043

McLaren Cancer Institute-Macomb, Mount Clemens

48044

Michigan Healthcare Professionals Macomb, Macomb

48060

McLaren-Port Huron, Port Huron

48071

Michigan Healthcare Professionals Madison Heights, Madison Heights

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48093

Henry Ford Health Warren Hospital, Warren

48098

Michigan Healthcare Professionals Troy, Troy

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Michigan Healthcare Professionals Farmington, Farmington Hills

Weisberg Cancer Treatment Center, Farmington Hills

48341

Michigan Healthcare Professionals Pontiac, Pontiac

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

McLaren Cancer Institute-Clarkston, Clarkston

Michigan Healthcare Professionals Clarkston, Clarkston

48446

McLaren Cancer Institute-Lapeer Region, Lapeer

48532

McLaren Cancer Institute-Flint, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48858

McLaren Cancer Institute-Central Michigan, Mount Pleasant

48910

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

48912

Mid-Michigan Physicians-Lansing, Lansing

University of Michigan Health - Sparrow Lansing, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49201

Allegiance Health, Jackson

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49770

McLaren Cancer Institute-Northern Michigan, Petoskey

50010

McFarland Clinic - Ames, Ames

52403

Mercy Hospital, Cedar Rapids

53024

Aurora Cancer Care-Grafton, Grafton

53038

University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53097

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon

53142

Aurora Cancer Care-Kenosha South, Kenosha

53154

Drexel Town Square Health Center, Oak Creek

53211

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53295

Zablocki Veterans Administration Medical Center, Milwaukee

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

ThedaCare Regional Cancer Center, Appleton

55101

Regions Hospital, Saint Paul

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55435

Fairview Southdale Hospital, Edina

55805

Saint Luke's Hospital of Duluth, Duluth

55905

Mayo Clinic in Rochester, Rochester

56001

Mayo Clinic Health Systems-Mankato, Mankato

56007

Mayo Clinic Health System in Albert Lea, Albert Lea

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

57105

Avera Cancer Institute, Sioux Falls

58122

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59715

Bozeman Health Deaconess Hospital, Bozeman

59901

Logan Health Medical Center, Kalispell

60126

Elmhurst Memorial Hospital, Elmhurst

60153

Loyola University Medical Center, Maywood

60426

Ingalls Memorial Hospital, Harvey

60540

Edward Hospital/Cancer Center, Naperville

60585

Edward Hospital/Cancer Center?Plainfield, Plainfield

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62002

Alton Memorial Hospital, Alton

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Decatur Memorial Hospital, Decatur

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

Saint Francis Medical Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64131

The University of Kansas Cancer Center-South, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

65401

Phelps Health Delbert Day Cancer Institute, Rolla

65804

Mercy Hospital Springfield, Springfield

66061

The University of Kansas Cancer Center - Olathe, Olathe

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66606

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka

67214

Ascension Via Christi Hospitals Wichita, Wichita

68114

Nebraska Methodist Hospital, Omaha

70006

East Jefferson General Hospital, Metairie

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70121

Ochsner Medical Center Jefferson, New Orleans

72401

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77573

UTMB Cancer Center at Victory Lakes, League City

80045

UCHealth University of Colorado Hospital, Aurora

80524

Poudre Valley Hospital, Fort Collins

80907

Penrose-Saint Francis Healthcare, Colorado Springs

80909

UCHealth Memorial Hospital Central, Colorado Springs

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85004

Cancer Center at Saint Joseph's, Phoenix

85704

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

89106

Radiation Oncology Centers of Nevada Central, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

92093

UC San Diego Moores Cancer Center, La Jolla

92134

Naval Medical Center -San Diego, San Diego

93720

Fresno Cancer Center, Fresno

Kaiser Permanente-Fresno, Fresno

94063

Kaiser Permanente-Redwood City, Redwood City

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

Kaiser Permanente-South San Francisco, South San Francisco

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

Kaiser Permanente-San Francisco, San Francisco

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94568

Kaiser Permanente Dublin, Dublin

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

Sutter Solano Medical Center/Cancer Center, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland-Broadway, Oakland

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

Kaiser San Rafael-Gallinas, San Rafael

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

95823

Kaiser Permanente-South Sacramento, Sacramento

South Sacramento Cancer Center, Sacramento

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

95973

Adventist Health Cancer Care Center Chico, Chico

96161

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

97015

Clackamas Radiation Oncology Center, Clackamas

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

98001

MultiCare Auburn Medical Center, Auburn

99701

Fairbanks Memorial Hospital, Fairbanks

02118

Boston Medical Center, Boston

01805

Lahey Hospital and Medical Center, Burlington

01960

Lahey Medical Center-Peabody, Peabody

01890

Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08210

AtlantiCare Health Park-Cape May Court House, Cape May Court House

08234

AtlantiCare Surgery Center, Egg Harbor

08876

Robert Wood Johnson University Hospital Somerset, Somerville

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77555-0565

University of Texas Medical Branch, Galveston

05201

Southwestern Vermont Medical Center, Bennington

05819

Dartmouth Cancer Center - North, Saint Johnsbury

T2N 5G2

Arthur J E Child Comprehensive Cancer Centre, Calgary

00927

Centro Comprensivo de Cancer de UPR, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER