80
Participants
Start Date
April 30, 2017
Primary Completion Date
December 31, 2023
Study Completion Date
April 30, 2024
Exercise capacity VO2 max determination
Each participant's maximal oxygen capacity will be determined using a modified Bruce treadmill protocol.
Standardized meals
Participants will consume the standardized study diet for 3 days provided by the clinical research unit's metabolic kitchen (at UAB).
Exercise challenge
Each participant will walk at 70 % of his/her VO2max for 20 minutes on treadmill.
Metoprolol Succinate ER
Each participant will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day for total duration of 6 weeks.
University of Alabama at Birmingham, Birmingham
National Heart, Lung, and Blood Institute (NHLBI)
NIH
University of Alabama at Birmingham
OTHER