A Study of Pembrolizumab (MK-3475) in Combination With Etoposide/Platinum (Cisplatin or Carboplatin) for Participants With Extensive Stage Small Cell Lung Cancer (MK-3475-604/KEYNOTE-604)

PHASE3CompletedINTERVENTIONAL
Enrollment

453

Participants

Timeline

Start Date

May 2, 2017

Primary Completion Date

December 2, 2019

Study Completion Date

September 21, 2021

Conditions
Small Cell Lung Cancer (SCLC)
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion on Day 1 of each cycle prior to chemotherapy

DRUG

Normal saline solution

IV infusion on Day 1 of each cycle prior to chemotherapy

DRUG

Carboplatin

IV infusion on Day 1 of each cycle

DRUG

Cisplatin

IV infusion on Day 1 of each cycle

DRUG

Etoposide

IV infusion on Days 1, 2 and 3 of each cycle

Trial Locations (148)

704

National Cheng Kung University Hospital ( Site 1004), Tainan City

736

Chi Mei Medical Center Liuying ( Site 1006), Tainan City

1011

CHUV Centre Hospitalier Universitaire Vaudois ( Site 1405), Lausanne

1121

Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 0452), Budapest

Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 0458), Budapest

Orszagos Koranyi TBC es Pulmonologiai Intezet ( Site 0459), Budapest

1122

Orszagos Onkologiai Intezet ( Site 0453), Budapest

2148

Blacktown Hospital ( Site 0004), Blacktown

2500

Southern Medical Day Care Centre ( Site 0001), Wollongong

3065

St Vincents Hospital Melbourne ( Site 0005), Fitzroy

5000

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0451), Szolnok

5112

Lyell McEwin Hospital ( Site 0002), Elizabeth Vale

6150

St John of God ( Site 0006), Murdoch

7000

Kantonsspital Graubuenden ( Site 1403), Chur

8000

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz ( Site 0456), Székesfehérvár

8011

Canterbury Regional Cancer & Blood Services ( Site 0701), Christchurch

8091

Universitaetsspital Zuerich ( Site 1404), Zurich

8582

Veszprem Megyei Tudogyogyintezet ( Site 0454), Farkasgyepű

8900

Zala Megyei Szent Rafael Korhaz ( Site 0457), Zalaegerszeg

9023

Petz Aladar Megyei Oktato Korhaz ( Site 0460), Győr

10002

National Taiwan University Hospital ( Site 1001), Taipei

10065

Memorial Sloan Kettering Cancer Center ( Site 1211), New York

10408

National Cancer Center ( Site 0904), Goyang-si

10461

Montefiore Einstein Center for Cancer Care - Main site ( Site 1204), The Bronx

10467

Montefiore Medical Center ( Site 1222), The Bronx

10604

Memorial Sloan Kettering Cancer Center ( Site 1229), Harrison

11217

Taipei Veterans General Hospital ( Site 1002), Taipei

11570

Memorial Sloan Kettering Cancer Center - Rockville Centre ( Site 1228), Rockville Centre

11725

Memorial Sloan-Kettering Cancer Center at Commack ( Site 1227), Commack

13125

Evangelische Lungenklinik Berlin ( Site 0403), Berlin

15006

Complejo Hospitalario Universitario de A Coruna ( Site 0953), A Coruña

21075

Asklepios Klinikum Harburg ( Site 0412), Hamburg

21237

Weinberg Cancer Institute at Franklin Square ( Site 1210), Baltimore

22030

Trakya Uni. Tip Fakultesi ( Site 1063), Edirne

23007

Hospital Ciudad de Jaen ( Site 0957), Jaén

27710

Duke University Medical Center ( Site 1214), Durham

28007

Hospital General Universitario Gregorio Maranon ( Site 0958), Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz ( Site 0954), Madrid

29607

Bon Secours St. Francis Health Sytem ( Site 1212), Greenville

31059

CHU de Toulouse - Hopital Larrey ( Site 0354), Toulouse

33176

Baptist Health Medical Group Oncology, LLC ( Site 8000), Miami

34098

Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1058), Istanbul

34214

Medipol Hastanesi ( Site 1066), Istanbul

34722

Medeniyet Uni. Goztepe Egitim ve Arast. Hast. ( Site 1064), Istanbul

35016

Hospital Universitario Insular de Gran Canaria ( Site 0952), Las Palmas de Gran Canaria

35032

Philipps-Universitat Marburg ( Site 0414), Marburg

35100

Ege Universitesi Tıp Fakultesi ( Site 1052), Izmir

35575

Medical Park Izmir Hospital ( Site 1051), Izmir

37203

Tennessee Oncology, PLLC/The Sarah Cannon Research Institute ( Site 1230), Nashville

39401

Hattiesburg Clinic ( Site 1205), Hattiesburg

40447

China Medical University Hospital. ( Site 1003), Taichung

40489

Florence Nightingale Krankenhaus ( Site 0413), Düsseldorf

40705

Taichung Veterans General Hospital ( Site 1007), Taichung

41380

Kocaeli Universitesi Tip Fakultesi ( Site 1061), Kocaeli

44280

Inonu Universitesi Tip Fakultesi ( Site 1059), Malatya

44805

CHU Nantes - Hopital Laennec ( Site 0363), Nantes

46010

Hospital Clinico Universitario de Valencia ( Site 0955), Valencia

46321

Community Hospital ( Site 1207), Munster

48108

Inje University Haeundae Paik Hospital ( Site 0905), Busan

48202

Henry Ford Health System ( Site 1221), Detroit

51726

Institut de Cancerologie Jean-Godinot ( Site 0351), Reims

55404

Minnesota Oncology Hematology, PA ( Site 8001), Minneapolis

59037

CHRU de Lille - Hopital Albert Calmette ( Site 0353), Lille

60201

North Shore University Health System ( Site 1216), Evanston

60612

Rush University Medical Center ( Site 1215), Chicago

63141

Mercy Hospital Saint Louis ( Site 1213), St Louis

69126

Thoraxklinik Heidelberg gGmbH am Universitaetsklinikum Heidelberg ( Site 0401), Heidelberg

72076

Universitaetsklinikum Tuebingen ( Site 0404), Tübingen

75020

Hopital Tenon ( Site 0360), Paris

75246

Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 8003), Dallas

78745

Texas Oncology ( Site 8002), Austin

83301

Kaohsiung Chang Gung Memorial Hospital of the C.G.M.F. ( Site 1005), Kaohsiung City

87042

C.H.R.U. De Limoges ( Site 0358), Limoges

89074

Comprehensive Cancer Centers of Nevada ( Site 8004), Henderson

115478

N.N. Blokhin NMRCO ( Site 0801), Moscow

194291

SBHI Leningrad Regional Clinical Hospital ( Site 0803), Saint Petersburg

198255

Municipal Clinical Oncology Center ( Site 0802), Saint Petersburg

308010

Belgorod Regional Oncology Dispensary ( Site 0804), Belgorod

357502

SBI of Stavropol region Pyatigorskiy Oncologic dispensary ( Site 0811), Pyatigorsk

3465584

Clinica Universidad Catolica del Maule ( Site 0208), Talca

3525408

Ramban Medical Center - Dept. Hemato. & B. Marrow Transplant ( Site 0502), Haifa

4428164

Meir Medical Center ( Site 0503), Kfar Saba

5262000

Rabin Medical Center ( Site 0504), Petah Tikva

5265601

Chaim Sheba Medical Center. ( Site 0501), Ramat Gan

7500006

Health and Care Chile ( Site 0202), Santiago

7500921

Fundacion Arturo Lopez Perez FALP ( Site 0203), Santiago

8330032

Pontificia Universidad Catolica de Chile ( Site 0206), Santiago

8380455

Instituto Nacional del Cancer ( Site 0207), Santiago

8489501

Soroka Medical Center ( Site 0505), Beersheba

02114

Massachusetts General Hospital ( Site 1203), Boston

02215

Beth Israel Deaconess Medical Center ( Site 1206), Boston

Dana-Farber Cancer Institute [Boston] ( Site 1201), Boston

48109-5936

University of Michigan ( Site 1217), Ann Arbor

07920

Memorial Sloan-Kettering Cancer Center At Basking Ridge ( Site 1226), Basking Ridge

07748

Memorial Sloan Kettering Cancer Center- Monmouth ( Site 1225), Middletown

R3E 0V9

Cancer Care Manitoba ( Site 0159), Winnipeg

B3H 1V7

Nova Scotia Health Authority ( Site 0157), Halifax

L6R 3J7

William Osler Health System (Brampton Civic Hospital) ( Site 0161), Brampton

K7L 2V7

Kingston Health Sciences Centre ( Site 0155), Kingston

M4N 3M5

Sunnybrook Research Institute ( Site 0151), Toronto

J4V 2H1

CISSS de la Monteregie-Centre ( Site 0152), Greenfield Park

G6V 3Z1

CISSS-CA Hotel Dieu de Levis ( Site 0154), Lévis

H3T 1M5

CIUSSS Ouest de l'Ile - St-Mary's Hospital ( Site 0158), Montreal

J7Z 5T3

St. Jerome Medical Research Inc. ( Site 0160), Saint-Jérôme

06189

Centre Antoine Lacassagne ( Site 0362), Nice

01307

Medizinische Fakultaet Carl Gustav Carus der TU Dresden ( Site 0411), Dresden

07548

SRH Waldklinikum Gera GmbH ( Site 0405), Gera

D04 Y8V0

St Vincents University Hospital ( Site 1456), Dublin

D08 K0Y5

St James Hospital ( Site 1452), Dublin

460-0001

National Hospital Organization Nagoya Medical Center ( Site 0615), Nagoya

277-8577

National Cancer Center Hospital East ( Site 0613), Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 0614), Matsuyama

830-0011

Kurume University Hospital ( Site 0609), Kurume

673-8558

Hyogo Cancer Center ( Site 0611), Akashi

241-8515

Kanagawa Cancer Center ( Site 0618), Yokohama

980-0873

Sendai Kousei Hospital ( Site 0602), Sendai

591-8555

National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0608), Sakai

411-8777

Shizuoka Cancer Center Hospital and Research Institute ( Site 0607), Sunto-gun

755-0241

National Hospital Organization Yamaguchi Ube Medical Center ( Site 0601), Ube

810-8563

National Hospital Organization Kyushu Medical Center ( Site 0617), Fukuoka

734-8551

Hiroshima University Hospital ( Site 0604), Hiroshima

951-8566

Niigata Cancer Center Hospital ( Site 0610), Niigata

541-8567

Osaka International Cancer Institute ( Site 0616), Osaka

135-8550

The Cancer Institute Hospital of JFCR ( Site 0606), Tokyo

641-8509

Wakayama Medical University Hospital ( Site 0612), Wakayama

05-135

Mazowiecki Szpital Onkologiczny ( Site 0757), Wieliszew

62-500

Przychodnia Lekarska Komed ( Site 0769), Konin

31-202

Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 0768), Krakow

20-090

Centrum Onkologii Ziemi Lubelskiej im. sw. Jana z Dukli ( Site 0767), Lublin

60-569

SKPP UM im. Karola Marcinkowkiego w Poznaniu ( Site 0766), Poznan

Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 0762), Poznan

87-100

Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu ( Site 0756), Torun

02-781

Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie ( Site 0751), Warsaw

53-413

Dolnoslaskie Centrum Onkologii we Wroclawiu ( Site 0771), Wroclaw

03722

Severance Hospital Yonsei University Health System ( Site 0903), Seoul

05505

Asan Medical Center ( Site 0901), Seoul

06351

Samsung Medical Center ( Site 0902), Seoul

08003

Hospital del Mar ( Site 0956), Barcelona

08035

Hospital Universitari Vall d Hebron ( Site 0951), Barcelona

01250

Baskent University Adana Dr. Turgut Noyan EAH ( Site 1057), Adana

06100

Ankara UTF ( Site 1055), Ankara

Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1060), Ankara

06200

Dr. Abdurrahman Yurtaslan Ankara Onkoloji EAH ( Site 1053), Ankara

B9 5SS

Birmingham Heartlands Hospital ( Site 1162), Birmingham

LS9 7TF

St James s University Hospital ( Site 1161), Leeds

N18 1QX

North Middlesex Hospital ( Site 1151), London

ME16 9QQ

Maidstone Hospital ( Site 1155), Maidstone

HA6 2RN

Mount Vernon Cancer Centre ( Site 1156), Northwood

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03066778 - A Study of Pembrolizumab (MK-3475) in Combination With Etoposide/Platinum (Cisplatin or Carboplatin) for Participants With Extensive Stage Small Cell Lung Cancer (MK-3475-604/KEYNOTE-604) | Biotech Hunter | Biotech Hunter