The Effects of Anthracycline-based Chemotherapy on Peripheral Vascular Function

CompletedOBSERVATIONAL
Enrollment

60

Participants

Timeline

Start Date

February 1, 2017

Primary Completion Date

August 1, 2018

Study Completion Date

August 1, 2018

Conditions
Breast CancerLymphomaChemotherapy Effect
Interventions
OTHER

Arterial blood pressure

Continuously monitored for 5-30 minutes via finger photoplesmography

OTHER

Vascular Ultrasound

Assessment of carotid artery cross sectional area and intima-media thickness. Assessment of brachial artery diameter

OTHER

Venous blood sample

Evaluation of oxidative stress via serum lipid hydroperoxide

OTHER

Skin microcirculatory blood flow

Assessed non-invasively in the forearm skin via Laser Doppler flowmetry in response to locally delivered acetylcholine (ACh) and sodium nitroprusside (SNP) via iontophoresis.

Trial Locations (1)

66502

Lafene Health Center, Manhattan

All Listed Sponsors
lead

Carl Ade, M.S., Ph.D.

OTHER

NCT03062878 - The Effects of Anthracycline-based Chemotherapy on Peripheral Vascular Function | Biotech Hunter | Biotech Hunter