Study of Pembrolizumab (MK-3475) or Placebo Given With Best Supportive Care in Asian Participants With Previously Treated Advanced Hepatocellular Carcinoma (MK-3475-394/KEYNOTE-394)

PHASE3CompletedINTERVENTIONAL
Enrollment

453

Participants

Timeline

Start Date

April 27, 2017

Primary Completion Date

June 30, 2021

Study Completion Date

October 15, 2024

Conditions
Carcinoma, Hepatocellular
Interventions
BIOLOGICAL

pembrolizumab

Administered as an intravenous (IV) infusion every 3 weeks (Q3W)

DRUG

placebo

Normal saline solution administered as an IV infusion Q3W

OTHER

best supportive care (BSC)

BSC will include pain management and management of other potential complications including ascites per local standards of care.

Trial Locations (41)

613

Chia-Yi Chang Gung Memorial Hospital ( Site 0133), Chiayi City

40447

China Medical University Hospital ( Site 0131), Taichung

46050

Beacon Hospital Sdn Bhd ( Site 0092), Petaling Jaya

56000

Hospital Universiti Kebangsaan Malaysia ( Site 0093), Cheras

59100

University Malaya Medical Centre ( Site 0091), Kuala Lumpur

70403

National Cheng Kung University Hospital ( Site 0132), Tainan City

100142

Beijing Cancer Hospital ( Site 0010), Beijing

116011

The First Affiliated Hospital of Dalian Medical University ( Site 0022), Dalian

130012

Jilin Province Cancer Hospital, Department of Chemotherapy ( Site 0002), Changchun

130021

The First Hospital Of Jilin University ( Site 0001), Changchun

200032

Fudan University Shanghai Cancer Center ( Site 0024), Shanghai

Zhongshan Hospital Fudan University ( Site 0012), Shanghai

200127

Renji Hosp,Shanghai Jiao Tong University School of Medicine ( Site 0017), Shanghai

210009

Jiangsu Cancer Hospital ( Site 0003), Nanjing

210031

The 81st Hospital of PLA ( Site 0016), Nanjing

215006

The First Affiliated Hospital of Soochow University ( Site 0025), Suzhou

225012

Yangzhou No.1 People's Hospital ( Site 0023), Yangzhou

226361

Nantong Tumor Hospital ( Site 0028), Nantong

230001

Anhui Provincial Hospital ( Site 0032), Hefei

230022

The First Affiliated Hospital of Anhui Medical University ( Site 0005), Hefei

230601

The Second Affiliated Hospital of Anhui Medical University ( Site 0008), Hefei

233030

Bengbu Medical College First Affiliated Hospital ( Site 0020), Bengbu

310003

The First affiliated Hospital Zhejing University ( Site 0034), Hangzhou

310022

Zhejiang Cancer Hospital ( Site 0011), Hangzhou

350025

Fuzhou General Hospital of Nanjing Military Command ( Site 0019), Fuzhou

410006

Hunan Cancer Hospital ( Site 0027), Changsha

410013

The Third Xiangya Hospital of Central South University ( Site 0026), Changsha

430030

Wuhan Tongji Hospital ( Site 0021), Wuhan

430079

Hubei Cancer Hospital ( Site 0035), Wuhan

510080

Guangdong General Hospital ( Site 0015), Guangzhou

528000

The First People s Hospital of Foshan ( Site 0033), Foshan

610000

Harbin Medical University Cancer Hospital ( Site 0007), Harbin

West China Hospital of Sichuan University ( Site 0030), Chengdu

710061

The first affiliated Hospital of Xi an Jiaotong University ( Site 0014), Xi’an

Unknown

Hong Kong Sanatorium Hospital ( Site 0053), Hong Kong

Pamela Youde Nethersole Eastern Hospital ( Site 0052), Hong Kong

Princess Margaret Hospital. ( Site 0051), Hong Kong

03080

Seoul National University Hospital ( Site 0074), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 0073), Seoul

05505

Asan Medical Center ( Site 0072), Seoul

06351

Samsung Medical Center ( Site 0071), Seoul

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03062358 - Study of Pembrolizumab (MK-3475) or Placebo Given With Best Supportive Care in Asian Participants With Previously Treated Advanced Hepatocellular Carcinoma (MK-3475-394/KEYNOTE-394) | Biotech Hunter | Biotech Hunter