31
Participants
Start Date
May 16, 2017
Primary Completion Date
June 2, 2020
Study Completion Date
June 2, 2020
Fecal microbiota transplantation (FMT)
One fecal microbiota transplantation is performed at baseline using gastroscopic guidance. The transplant consists of 50 g feces obtained from a healthy non-related donor. The donor feces is suspended into NaCl (0.9%) and glycerol (10%), and will be stored at minus 80 degrees celsius until use. The total volume of the suspension is 250 mL and its temperature will be 37 degrees celsius when infused into the small intestine of the recipient.
Drug: Placebo (saline)
One identical appearing sham procedure is performed at baseline using gastroscopic guidance. 250 mL saline (NaCl 0.9%) is infused into the small intestine of the recipient.
Methotrexate (MTX)
Weekly methotrexate in maximum tolerable dosis
Dept. of Rheumatology at Odense University Hospital, Odense
Diagnostic Centre at Silkeborg Regional Hospital, Silkeborg
Region of Southern Denmark
OTHER
University of Southern Denmark
OTHER
The Danish Rheumatism Association
OTHER
Odense Patient Data Explorative Network
OTHER
The Psoriasis Association, Denmark
UNKNOWN
Manufacturer Vilhelm Pedersen Foundation
OTHER
The Danish Regions (Medicinpuljen)
UNKNOWN
Odense University Hospital
OTHER