16
Participants
Start Date
March 14, 2017
Primary Completion Date
May 15, 2017
Study Completion Date
May 15, 2017
JNJ-54175446 150 mg
Subjects will receive JNJ-54175446 150 mg capsules orally (1\*100 mg + 1\*50 mg) under fasted conditions on Day 7, 9, 10 and 11.
JNJ-54175446 600 mg
Subjects will receive JNJ-54175446 600 mg (6\*100 mg capsules) orally on Day 8.
Midazolam 2 mg
Subjects will receive midazolam 2 mg oral emulsion \[2 (milligram per milliliter (mg/mL)\] as a drug cocktail on Day 1, 7 and 11.
Warfarin 10 mg
Subjects will receive warfarin 10 mg tablets (2\*5 mg) orally as a drug cocktail on Day 1, 7 and 11.
Caffeine 50 mg
Subjects will receive caffeine 50 mg tablet (1\*50 mg) orally as a drug cocktail on Day 1, 7 and 11.
Dextromethorphan 30 mg
Subjects will receive dextromethorphan 30 mg capsule (1\*30 mg) orally as a drug cocktail on Day 1, 7 and 11.
Bupropion 150 mg
Subjects will receive Bupropion 150 mg tablet (1\*150 mg) orally as a drug cocktail on Day 1, 7 and 11.
Omeprazole 20 mg
Subjects will receive omeprazole 20 mg capsule (1\*20 mg) orally as a drug cocktail on Day 1, 7 and 11.
Clinical Pharmacology Unit, Merksem
Janssen Research & Development, LLC
INDUSTRY