35
Participants
Start Date
June 10, 2017
Primary Completion Date
June 1, 2020
Study Completion Date
August 1, 2022
ribociclib
Ribociclib (LEE-011) will be given on days 1-4, 8-11, and 15-18 of a 28 day cycle at 200, 400, or 600mg/day during the dose escalation phase. During the maintenance phase, ribociclib (LEE-011) will be given at 600mg/day, 3 weeks on, 1 week off until progression.
Paclitaxel
During the escalation phase Paclitaxel will be given on days 1, 8, and 15 of a 28 day cycle.
Carboplatin
During the escalation phase Carboplatin will be given on days 1, 8, and 15 of a 28 day cycle.
UPMC Hillman Cancer Center Upper St. Clair, Bethel Park
University of Pittsburgh Medical Center, Pittsburgh
UPMC Hillman Cancer Center Passavant (OHA), Pittsburgh
UPMC Hillman Cancer Center Washington, Washington
UPMC Hillman Cancer Center Arnold Palmer at Mountain View, Greensburg
UPMC Hillman Cancer Center Arnold Palmer Medical at Norwin, Irwin
UPMC Hillman Cancer Center Arnold Palmer at Mt Pleasant, Mount Pleasant
University of Michigan Comprehensive Cancer Center, Ann Arbor
Ronald Buckanovich
OTHER