Inflammation and Threat Sensitivity in PTSD

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 1, 2019

Primary Completion Date

March 30, 2020

Study Completion Date

March 31, 2021

Conditions
Posttraumatic Stress Disorder
Interventions
BIOLOGICAL

Typhoid Vi Polysaccharide Vaccine

Salmonella typhi capsular polysaccharide vaccine (Typhoid Vi Polysaccharide Vaccine): Each dose of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA) is formulated to contain 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection. It is indicated for use by humans aged 2 years and older for protection against typhoid fever.

BIOLOGICAL

Placebo

The placebo injection will consist of 0.5mL of saline.

Trial Locations (2)

94121

San Francisco Veterans Affairs Medical Center, San Francisco

94143

University of California, San Francisco, San Francisco

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

University of California, San Francisco

OTHER

NCT03048929 - Inflammation and Threat Sensitivity in PTSD | Biotech Hunter | Biotech Hunter