Durvalumab ± Tremelimumab in Combination With Platinum Based Chemotherapy in Untreated Extensive-Stage Small Cell Lung Cancer (CASPIAN)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

987

Participants

Timeline

Start Date

March 27, 2017

Primary Completion Date

January 27, 2020

Study Completion Date

December 31, 2025

Conditions
Small Cell Lung Carcinoma Extensive Disease
Interventions
DRUG

Durvalumab

IV infusions every 3 weeks for 12 weeks (4 cycles) and every 4 weeks thereafter until PD or other discontinuation criteria.

DRUG

Tremelimumab

IV infusions every 3 weeks for 12 weeks(4 cycles). An additional dose of tremelimumab will be administered in the week 16.

DRUG

Carboplatin

up to 4 cycles every 3 weeks in Arm 1 and 2, up to 6 cycles every 3 weeks in Arm 3

DRUG

Cisplatin

up to 4 cycles every 3 weeks in Arm 1 and 2, up to 6 cycles every 3 weeks in Arm 3

DRUG

Etoposide

up to 4 cycles every 3 weeks in Arm 1 and 2, up to 6 cycles every 3 weeks in Arm 3

Trial Locations (207)

235

Research Site, Taipei

704

Research Site, Tainan City

736

Research Site, Tainan City

1083

Research Site, Budapest

1106

Research Site, Budapest

1121

Research Site, Budapest

1134

Research Site, Budapest

1140

Research Site, Vienna

1210

Research Site, Vienna

1330

Research Site, Sofia

1431

Research Site, Sofia

1618

Research Site, Sofia

1784

Research Site, Sofia

2000

Research Site, Rosario

3529

Research Site, Miskolc

4000

Research Site, Plovdiv

4004

Research Site, Plovdiv

4021

Research Site, Linz

4500

Research Site, Panagyurishte

5020

Research Site, Salzburg

5700

Research Site, Gyula

6000

Research Site, Kecskemét

6772

Research Site, Deszk

7400

Research Site, Kaposvár

7600

Research Site, Mar del Plata

7624

Research Site, Pécs

8000

Research Site, Székesfehérvár

9010

Research Site, Varna

11217

Research Site, Taipei

11501

Research Site, Mineola

13125

Research Site, Berlin

13620

Research Site, Seongnam-si

15006

Research Site, A Coruña

17109

Research Site, Harrisburg

20133

Research Site, Milan

20251

Research Site, Hamburg

21029

Research Site, Vinnytsia

21565

Research Site, Incheon

22030

Research Site, Edirne

24127

Research Site, Bergamo

25006

Research Site, Kirovohrad

28040

Research Site, Madrid

28041

Research Site, Madrid

28644

Research Site, Cheongju-si

29609

Research Site, Brest

30607

Research Site, Athens

32098

Research Site, Istanbul

35033

Research Site, Rennes

35100

Research Site, Izmir

35235

Research Site, Birmingham

35620

Research Site, Izmir

37203

Research Site, Nashville

38043

Research Site, La Tronche

39008

Research Site, Santander

40022

Research Site, Sumy

40447

Research Site, Taichung

40705

Research Site, Taichung

42003

Research Site, Paducah

42415

Research Site, Daegu

43219

Research Site, Columbus

44106

Research Site, Cleveland

46010

Research Site, Valencia

46804

Research Site, Fort Wayne

47014

Research Site, Meldola

47303

Research Site, Muncie

49100

Research Site, Petah Tikva

49102

Research Site, Dnipro

49503

Research Site, Grand Rapids

50006

Research Site, Changhua

50009

Research Site, Zaragoza

50048

Research Site, Kryvyi Rih

51353

Research Site, Changwon

52074

Research Site, Aachen

55131

Research Site, Mainz

57104

Research Site, Sioux Falls

65055

Research Site, Odesa

66209

Research Site, Leawood

67214

Research Site, Wichita

69040

Research Site, Zaporizhzhia

69126

Research Site, Heidelberg

69310

Research Site, Pierre-Bénite

72758

Research Site, Rogers

76018

Research Site, Ivano-Frankivsk

79031

Research Site, Lviv

82131

Research Site, Gauting

82445

Research Site, Kaohsiung City

82606

Research Site, Bratislava

83301

Research Site, Kaohsiung City

84918

Research Site, Avignon

85259

Research Site, Scottsdale

90146

Research Site, Palermo

90404

Research Site, Santa Monica

91031

Research Site, Jerusalem

91708

Research Site, Trnava

93053

Research Site, Regensburg

94010

Research Site, Créteil

95847

Research Site, Kfar Saba

97517

Research Site, Banská Bystrica

99336

Research Site, Kennewick

100142

Research Site, Beijing

100730

Research Site, Beijing

100853

Research Site, Beijing

105229

Research Site, Moscow

110042

Research Site, Shenyang

110746

Research Site, Seoul

130021

Research Site, Changchun

194291

Research Site, Saint Petersburg

195271

Research Site, Saint Petersburg

196603

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

200032

Research Site, Shanghai

200433

Research Site, Shanghai

210009

Research Site, Nanjing

210029

Research Site, Nanjing

230601

Research Site, Hefei

233004

Research Site, Bengbu

310003

Research Site, Hangzhou

310006

Research Site, Hangzhou

310009

Research Site, Hangzhou

325000

Research Site, Wenzhou

330006

Research Site, Nanchang

344037

Research Site, Rostov-on-Don

400015

Research Site, Cluj-Napoca

400038

Research Site, Chongqing

407280

Research Site, Floreşti

410013

Research Site, Changsha

430022

Research Site, Wuhan

430030

Research Site, Wuhan

450008

Research Site, Zhengzhou

450054

Research Site, Ufa

519099

Research Site, Zhuhai

524001

Research Site, Zhanjiang

610041

Research Site, Chengdu

644013

Research Site, Omsk

710038

Research Site, Xi'an

710061

Research Site, Xi'an

720237

Research Site, Suceava

830000

Research Site, Ürümqi

5265601

Research Site, Ramat Gan

06520

Research Site, New Haven

C1118AAT

Research Site, Buenos Aires

C1426

Research Site, Ciudad de Buenos Aires

T4000IAK

Research Site, San Miguel de Tucumán

14784-400

Research Site, Barretos

81520-060

Research Site, Curitiba

99010 260

Research Site, Passo Fundo

91350-200

Research Site, Porto Alegre

14048-900

Research Site, Ribeirão Preto

22793-080

Research Site, Rio de Janeiro

41.950-610

Research Site, Salvador

09060-650

Research Site, Santo André

15090-000

Research Site, São José do Rio Preto

03102-002

Research Site, São Paulo

639 00

Research Site, Brno

775 21

Research Site, Olomouc

703 84

Research Site, Ostrava - Vitkovice

128 08

Research Site, Prague

140 59

Research Site, Prague

CZ-150 18

Research Site, Prague

07548

Research Site, Gera

00100

Research Site, Roma

05100

Research Site, Terni

104-0045

Research Site, Chūōku

812-8582

Research Site, Fukuoka

960-1295

Research Site, Fukushima

670-8520

Research Site, Himeji-shi

740-8510

Research Site, Iwakuni-shi

227-8577

Research Site, Kashiwa

135-8550

Research Site, Kōtoku

830-0011

Research Site, Kurume-shi

606-8507

Research Site, Kyoto

791-0280

Research Site, Matsuyama

464-8681

Research Site, Nagoya

466-8560

Research Site, Nagoya

700-8558

Research Site, Okayama

591-8555

Research Site, Sakaishi

589-8511

Research Site, Sayama

770-8503

Research Site, Tokushima

755-0241

Research Site, Ube-shi

236-0004

Research Site, Yokohama

241-8515

Research Site, Yokohama

1066 CX

Research Site, Amsterdam

6815 AD

Research Site, Arnhem

9713 GZ

Research Site, Groningen

7555 DL

Research Site, Hengelo

6202 AZ

Research Site, Maastricht

3015 GD

Research Site, Rotterdam

15-027

Research Site, Bialystok

15-540

Research Site, Bialystok

20-954

Research Site, Lublin

10-357

Research Site, Olsztyn

02-781

Research Site, Warsaw

085 01

Research Site, Bardejov

833 01

Research Site, Bratislava

041 91

Research Site, Košice

940 01

Research Site, Nové Zámky

660-702

Research Site, Jinju

463-712

Research Site, Seongnam-si

05505

Research Site, Seoul

06008

Research Site, Badajoz

08916

Research Site, Badalona

08041

Research Site, Barcelona

08035

Research Site, Madrid

06230

Research Site, Ankara

Unknown

Research Site, Ankara

03022

Research Site, Kyiv

03115

Research Site, Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY