26
Participants
Start Date
February 22, 2017
Primary Completion Date
October 17, 2022
Study Completion Date
October 17, 2022
Leuprolide Acetate
22.5mg by intramuscular (IM) injection every 3 months
Docetaxel
75 mg/m2 IV will be given on day 1 every 3 weeks, up to 6 cycles. Dose may decreased in the following intervals: 65 mg/M2, 55 mg/M2, 35 mg/M2.
Bicalutamide
bicalutamide (Casodex) 50mg by mouth daily
Radiation
Radiation will be delivered in 1 to 5 fractions, and the dose and fractionation schedule will depend on the size and location of the lesion and the surrounding normal tissue constraints in accordance with AAPM Task Group 101 recommendations. Typical doses include 16 - 24 Gy in 1 fraction, 48 - 50 Gy in 4 fractions, and 50 - 60 Gy in 5 fractions.
Abiraterone Acetate
Abiraterone acetate 1000 mg / day may be given at the investigator's discretion.
Johns Hopkins Sibley Memorial Hospital, Washington D.C.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
OTHER