804
Participants
Start Date
April 5, 2017
Primary Completion Date
May 31, 2022
Study Completion Date
August 21, 2024
Pembrolizumab
Administered as an intravenous (IV) infusion every 3 weeks (Q3W)
Placebo
Normal saline or dextrose solution administered as an IV infusion Q3W
Cisplatin
100 mg/m\^2 administered as an IV infusion Q3W
Accelerated Fractionation (AFX) Radiotherapy
70 Gray (Gy) given in 35 fractions over 6 weeks
Standard Fractionation (SFX) Radiotherapy
70 Gy given in 35 fractions over 7 weeks
MacKay Memorial Hospital ( Site 0505), Taipei
Taipei Veterans General Hospital ( Site 0504), Taipei
Linkou Chang Gung Memorial Hospital ( Site 0502), Taoyuan District
Taichung Veterans General Hospital ( Site 0506), Taichung
Allgemeines Krankenhaus der Stadt Wien ( Site 0602), Vienna/Wien
Cliniques Universitaires Saint Luc - Bruxelles ( Site 0651), Brussels
Blacktown Hospital Western Sydney Local Health District ( Site 0304), Blacktown
Liverpool Hospital ( Site 0301), Liverpool
Peter MacCallum Cancer Centre ( Site 0300), Melbourne
UZ Leuven Campus Gasthuisberg ( Site 0652), Leuven
C.H.U. Sart Tilman-Service d'Oncologie Medicale ( Site 0654), Liège
Krankenhaus der Barmherzigen Schwestern Linz ( Site 0603), Linz
Royal Brisbane and Women s Hospital ( Site 0302), Herston
Princess Alexandra Hospital ( Site 0305), Brisbane
Royal Adelaide Hospital ( Site 0303), Adelaide
Clinique et Maternite Sainte-Elisabeth ( Site 0653), Namur
Landeskrankenhaus Salzburg ( Site 0600), Salzburg
Capital & Coast District Health Board - Wellington Hospital ( Site 0400), Wellington
Landeskrankenhaus - Universitatsklinikum Graz ( Site 0601), Graz
UZ Gent ( Site 0650), Ghent
National Taiwan University Hospital ( Site 0500), Taipei
Seoul National University Bundang Hospital ( Site 0453), Seongnam-si
University of Rochester - James P. Wilmot Cancer Center ( Site 0255), Rochester
St. Luke's Cancer Center - Anderson ( Site 0251), Easton
Istituto Nazionale Tumori ( Site 0950), Milan
Istituto Europeo di Oncologia ( Site 0953), Milan
Azienda Ospedaliera San Paolo ( Site 0952), Milan
Universitares Cancer Center Hamburg - UCCH ( Site 0811), Hamburg
University of Virginia Health System ( Site 0261), Charlottesville
Universitaetsklinikum Schleswig-Holstein-Campus Luebeck ( Site 0803), Lübeck
Fondazione IRCCS - Policlinico San Matteo ( Site 0960), Pavia
Hospital Doce de Octubre ( Site 1054), Madrid
Hospital Universitario Ramon y Cajal ( Site 1055), Madrid
Hospital Clinico San Carlos ( Site 1051), Madrid
Chungbuk National University Hospital ( Site 0454), Cheongju-si
Hospital Universitario Virgen de la Victoria ( Site 1056), Málaga
St. Francis Hospital Cancer Center ( Site 1461), Greenville
Medizinische Hochschule Hannover ( Site 0807), Hanover
Institut Claudius Regaud ( Site 0754), Toulouse
Istanbul Universitesi Istanbul Tip Fakultesi ( Site 1100), Istanbul
Medipol Universite Hastanesi ( Site 1104), Istanbul
Chungnam National University Hospital ( Site 0455), Daejeon
Istituto Oncologico Veneto ( Site 0957), Padua
Medical Park Izmir Hastanesi ( Site 1109), Izmir
Azienda Ospedaliero Universitaria di Modena Policlinico ( Site 0954), Modena
Kocaeli Universitesi Tip Fakultesi ( Site 1106), Kocaeli
Inonu Universitesi Tip Fakultesi ( Site 1101), Malatya
Oncology Hematology Care, Inc. ( Site 8003), Cincinnati
Hospital Gral Universitario de Valencia ( Site 1050), Valencia
Indiana University ( Site 0264), Indianapolis
University of Michigan Hospital and Health Systems ( Site 0267), Ann Arbor
Barbara Ann Karmanos Cancer Institute ( Site 0272), Detroit
Azienda Ospedaliero Universitaria Careggi ( Site 0955), Florence
Institut De Cancerologie De Lorraine ( Site 0758), Vandœuvre-lès-Nancy
St. Vincent Healthcare Frontier Cancer Center ( Site 0286), Billings
Rush University Medical Center ( Site 0260), Chicago
Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center ( Site 0290), Springfield
National Cheng Kung University Hospital ( Site 0503), Tainan City
Mary Bird Perkins Cancer Center at St. Tammany Parish Hospital ( Site 0281), Baton Rouge
Centre Jean Bernard Laboratoire Mahe Meziani ( Site 0760), Le Mans
Texas Oncology PA ( Site 8001), Longview
Texas Oncology-Arlington North ( Site 8005), Arlington
Texas Oncology-Austin Central ( Site 8002), Austin
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0951), Napoli
Klinikum der Universitaet Munchen ( Site 0810), München
Chang Gung Medical Foundation - Kaohsiung ( Site 0501), Kaohsiung City
Clinique Francois Chenieux ( Site 0757), Limoges
Universitaetsklinik Ulm ( Site 0804), Ulm
Comprehensive Cancer Centers of Nevada ( Site 8004), Las Vegas
UCLA Medical Center ( Site 0273), Los Angeles
Universitätsklinikum Erlangen ( Site 0801), Erlangen
University of California San Francisco ( Site 0274), San Francisco
Institut Gustave Roussy ( Site 0759), Villejuif
St. Joseph Heritage Healthcare ( Site 0254), Santa Rosa
Willamette Valley Cancer Institute and Research Center ( Site 8000), Eugene
Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 0269), Seattle
Medical Oncology Associates (Summit Cancer Centers) ( Site 0257), Spokane
Centro de Investigacion Clinica del Country ( Site 0155), Bogotá
Fundacion Valle del Lili ( Site 0150), Santiago de Cali
Centro Medico Imbanaco de Cali S.A ( Site 0156), Santiago de Cali
Rambam MC ( Site 0903), Haifa
Rabin Medical Center ( Site 0904), Petah Tikva
Sheba MC ( Site 0901), Ramat Gan
Tel Aviv Sourasky Medical Center ( Site 0900), Tel Aviv
Hadassah Ein Karem Jerusalem ( Site 0902), Jerusalem
Smilow Cancer Hospital at Yale New Haven ( Site 0256), New Haven
University of Massachusetts Memorial Medical Center ( Site 0285), Worcester
Centro Regional Integrado de Oncologia ( Site 0002), Fortaleza
Hospital Santa Izabel - Santa Casa de Misericordia da Bahia ( Site 0006), Salvador
Liga Norte Riograndense Contra o Cancer ( Site 0005), Natal
Hospital de Clinicas de Porto Alegre ( Site 0011), Porto Alegre
Hospital Nossa Senhora da Conceicao ( Site 0001), Porto Alegre
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0003), Barretos
Instituto do Cancer de Sao Paulo - ICESP ( Site 0004), São Paulo
Hospital das Clinicas da FMUSP de Ribeirao Preto ( Site 0008), Ribeirão Preto
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0010), Rio de Janeiro
Tom Baker Cancer Centre ( Site 0063), Calgary
Cross Cancer Institute ( Site 0064), Edmonton
Juravinski Cancer Centre ( Site 0062), Hamilton
London Health Sciences Centre ( Site 0055), London
The Ottawa Hospital - Cancer Care ( Site 0052), Ottawa
Princess Margaret Cancer Centre ( Site 0051), Toronto
McGill University Health Centre ( Site 0061), Montreal
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0057), Sherbrooke
Hospital Pablo Tobon Uribe ( Site 0151), Medellín
FN Brno. ( Site 0703), Brno
Fakultni Nemocnice Hradec Kralove ( Site 0705), Hradec Králové
Fakultni nemocnice Olomouc ( Site 0701), Olomouc
Fakultni nemocnice Ostrava ( Site 0702), Ostrava
2. LF UK a FN Motol ( Site 0704), Prague
Nemocnice Na Bulovce ( Site 0700), Prague
SRH Waldklinikum Gera GmbH ( Site 0802), Gera
National Cancer Center Hospital East ( Site 0350), Kashiwa
Hokkaido University Hospital ( Site 0351), Sapporo
Hyogo Cancer Center ( Site 0354), Akashi
Kagawa University Hospital ( Site 0359), Kita-gun
Miyagi Cancer Center ( Site 0353), Natori-shi
Chiba Cancer Center ( Site 0358), Chiba
Hiroshima University Hospital ( Site 0352), Hiroshima
Osaka International Cancer Institute ( Site 0355), Osaka
Medical Hospital, Tokyo Medical And Dental University ( Site 0356), Tokyo
The Cancer Institute Hospital of JFCR ( Site 0357), Tokyo
Noordwest Ziekenhuisgroep NWZ ( Site 1350), Alkmaar
VU Medisch Centrum ( Site 1352), Amsterdam
UMCG ( Site 1351), Groningen
UMC St. Radboud ( Site 1356), Nijmegen
Erasmus University Medical Center ( Site 1354), Rotterdam
Dolnoslaskie Centrum Onkologii. ( Site 1001), Wroclaw
Mazowiecki Szpital Onkologiczny ( Site 1015), Wieliszew
Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 1005), Bielsko-Biala
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1007), Gdynia
Centrum Onkologii. Instytut im. Marii Sklodowskiej-Curie ( Site 1010), Gliwice
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1008), Krakow
Zachodniopomorskie Centrum Onkologii ( Site 1013), Szczecin
Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie ( Site 1000), Warsaw
Severance Hospital Yonsei University Health System ( Site 0452), Seoul
Samsung Medical Center ( Site 0450), Seoul
H.U. Vall de Hebron ( Site 1052), Barcelona
Hospital Duran i Reynals ( Site 1053), L'Hospitalet de Llobregat
Basken Adana Dr.Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 1103), Adana
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 1102), Ankara
Ankara Sehir Hastanesi ( Site 1108), Ankara
Norfolk & Norwich University Hospital NHS Foundation Trust ( Site 1206), Norwich
University Hospital of North Staffordshire ( Site 1202), Stoke-on-Trent
Ipswich Hospital ( Site 1207), Ipswich
St Bartholomew s Hospital ( Site 1205), London
The Royal Marsden Foundation Trust ( Site 1200), London
Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 1204), London
Lancashire Teaching Hospitals NHS Foundation Trust ( Site 1208), Preston
University Hospital Southampton NHS Foundation Trust ( Site 1203), Southampton
Royal Marsden NHS Foundation Trust ( Site 1201), Sutton
Merck Sharp & Dohme LLC
INDUSTRY