100
Participants
Start Date
April 1, 2018
Primary Completion Date
January 1, 2026
Study Completion Date
June 30, 2026
Pentoxifylline
Pentoxifylline is a commonly used medication for muscle pain associated with peripheral artery disease. It is a methylated xanthine derivative that improves peripheral blood flow, flexibility of red blood cell membranes, microcirculation, and tissue oxygenation and reduces viscosity of blood.
Placebo
Placebo tablets
Tocopherol
Tocopherol (vitamin E) impairs tissue fibrosis and is a potent oxygen radical scavenger that may reduce damage caused by free radicals impacting necrosis.
New York Center for Orthognathic and Maxillofacial Surgery, Lake Success
University of Alabama at Birmingham, Birmingham
University of Washington, Seattle
University of Michigan, Ann Arbor
University of Alabama at Birmingham
OTHER
New York Center for Orthognathic and Maxillofacial Surgery
UNKNOWN
University of Michigan
OTHER
University of Washington
OTHER