A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

1,301

Participants

Timeline

Start Date

March 8, 2017

Primary Completion Date

February 8, 2022

Study Completion Date

August 12, 2022

Conditions
Ovarian CancerFallopian Tube CancerPeritoneal Neoplasms
Interventions
DRUG

Paclitaxel

Paclitaxel 175 milligrams per square meter (mg/m\^2) IV infusion on Day 1 of each 21-day cycle

DRUG

Carboplatin

Carboplatin at a dose to achieve a target area under the curve (AUC) of 6 milligrams per milliliter\*minute (mg/mL\*min) on Day 1 of each 21-day cycle for a total of 6 cycles

DRUG

Atezolizumab

Atezolizumab 1200 mg IV infusion on Day 1 of each 21-day cycle

DRUG

Bevacizumab

Bevacizumab 15 milligrams per kilogram (mg/kg) IV infusion as per the schedule specified in respective arms

DRUG

Atezolizumab Placebo

Placebo matching to atezolizumab on Day 1 of each 21-day cycle

Trial Locations (268)

1090

Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie, Vienna

2065

The Royal North Shore Hospital; Northern Sydney Cancer Centre, St Leonards

2100

Rigshospitalet; Onkologisk Klinik, København Ø

2610

Sint Augustinus Wilrijk, Wilrijk

3000

UZ Leuven Gasthuisberg, Leuven

3051

Peter MacCallum Cancer Center, North Melbourne

3144

Cabrini Hospital; Cabrini Foundation, Malvern

5020

Landeskrankenhaus Salzburg; Gynäkologie Und Onkologie, Salzburg

6020

Tiroler Landeskrankenanstalten Ges.M.B.H.; Abt. Für Gynäkologie, Innsbruck

7006

St. Olavs Hospital, Trondheim

8020

Krankenhaus Der Barmherzigen Brüder Graz; Gynäkologie, Graz

8208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

9000

AZ Maria Middelares, Ghent

UZ Gent, Ghent

10016

New York Univ Medical Center; Obstetrics & Gynecolog, New York

10029

Icahn School of Medicine at Mount Sinai, New York

10126

A. O. Città della Salute e della Scienza; Unità di Oncologia Ginecologica, Turin

10128

Ospedale Mauriziano Umberto 1; Ginecologia - Oncologia, Turin

10408

National Cancer Center, Goyang-si

11042

Northwell Health; Monter Cancer Center, Lake Success

11101

Memorial Sloan Kettering Cancer Center, New York

11355

New York Presbyterian Queens, Flushing

11570

Memorial Sloan-Kettering CC, Rockville Centre

12208

Womens Cancer Care Association, Albany

13353

Campus Virchow-Klinikum Charité; Centrum 17; Klinik für Gynäkologie, Berlin

15006

Onkologicka klinika UK 2.LF a FN v Motole, Prague

15213

Magee-Woman's Hospital, Pittsburgh

15224

Western Pennsylvania Hospital, Pittsburgh

17403

WellSpan Gynecologic Oncology, York

17475

Universitätsklinikum Greifswald; Klinik für Frauenheilkunde und Brustzentrum, Greifswald

18059

Klinikum Südstadt, Rostock

19090

Abington Mem Hosp-Abington; Rose. Can Ctr,Gyn Onc Ins, Willow Grove

19104

University of Pennsylvania Health System; Cancer Center, Philadelphia

19107

Thomas Jefferson University, Philadelphia

19140

Temple University Hospital, Philadelphia

20052

A.O. San Gerardo; Ginecologia, Monza

20132

IRCCS S. Raffaele; Ginecologia Oncologica, Milan

20133

Istituto Nazionale dei Tumori; Divisione Oncologia Chirurgica e Ginecologica, Milan

20141

Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milan

20162

Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia, Milan

20246

Universitätsklinikum Hamburg-Eppendorf (UKE); Klinik und Poliklinik für Gynäkologie, Hamburg

20521

Turku Uni Central Hospital; Gynaecology Dept, Turku

21204

Greater Baltimore Medical Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

21237

Weinberg CA Inst Franklin Sq, Baltimore

21701

Frederick Health Hospital, Frederick

22031

Virginia Cancer Specialists, PC, Fairfax

22601

Shenandoah Oncology Associates, Winchester

22906

University of Virginia, Charlottesville

23229

Henrico Doctors' Hospital - Forest, Richmond

23502

Virginia Oncology Associates, Norfolk

23538

Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe, Lübeck

25123

A.O.Spedali Civili; Ostetricia e Ginecologia, Brescia

27103

Forsythe Memorial Hospital Inc., dba Novant Health Oncology Specialists, Winston-Salem

27157

Wake Forest Baptist Medical Center, Winston-Salem

27710

Duke Medical Center, Durham

28007

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid

28050

Centro Integral Oncologico Clara Campal; Servicio de Oncología, Madrid

28204

Levine Cancer Institute, Charlotte

Novant Health Presbyterain Medical Center, Charlotte

28922

Fundacion Hospital de Alcorcon; Servicio de Oncologia, Alcorcón

29010

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga

29607

Bon Secours - St. Francis Hospital, Greenville

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center; Oncology Research Dept-5C, Gainesville

30625

Medizinische Hochschule Hannover, Klinik für Frauenheilkunde und Geburtshilfe, Hanover

33136

Sylvester Comprehensive Cent., Miami

33176

Miami Cancer Institute of Baptist Health, Inc., Miami

33520

Tampereen yliopistollinen sairaala, Tampere

33701

Women's Cancer Associates, St. Petersburg

34010

Koc University Medical Faculty; Department of Gynecology & Obstetrics, Istanbul

34093

Istanbul Uni Istanbul Medical Faculty, Istanbul

34098

Istanbul University Cerrahpasa Medical Faculty; Obstetrics and Gynecology, Istanbul

34239

Sarasota Memorial Health Care System; Cancer Research Program, Sarasota

35128

IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda, Padua

39216

St. Dominic-Jackson Memorial Hospital, Jackson

40138

Policlinico S.Orsola-Malpighi; Istituto Oncologia R. Addarii, Bologna

40536

University of Kentucky; Gynecologic Oncology, Lexington

41017

St. Elizabeth Edgewood; Cancer Care Center? for Account St. Elizabeth Edgewood, Edgewood

42100

Arcispedale Santa Maria Nuova; Oncologia, Reggio Emilia

43125

Columbus NCORP, Columbus

43210

Ohio State University, Arthur James Cancer Hospital, Columbus

44106

Cleveland Clinic, Cleveland

Univ Hospitals of Cleveland, Cleveland

44111

Fairview Hospital; Cleveland Clinic Cancer Center, Cleveland

44202

l'Hôpital privé du Confluent SAS, Nantes

45122

Universitätsklinikum Essen; Zentrum Für Frauenheilkunde, Essen

45136

Kliniken Essen Mitte Evang. Huyssens Stiftung/Knappschaft GmbH, Essen

45429

Kettering Medical Center, Kettering

46026

Hospital Universitario la Fe; Servicio de Oncologia, Valencia

46260

St.Vincent Health System; Gynecologic Oncology, Indianapolis

46845

Parkview Research Center, Fort Wayne

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola

48018

Ospedale Degli Infermi - Faenza; Oncologia Medica, Faenza

48106

St. Joseph Mercy Hospital, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

49684

Munson Medical Center, Traverse City

50009

Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza

52242

University of Iowa Hospital & Clinic; Division of Hematology/Oncology, Iowa City

53149

DN Greenwald Center, Mukwonago

53792

University of Wisconsin Hospital and Clinics, Madison

54401

Aspirus Regional Cancer Center, Wausau

55125

Minnesota Oncology Hematology Woodbury, Woodbury

55131

Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde, Mainz

55416

Metro-Minnesota Community Oncology Research Consortium, Saint Louis Park

55455

University of Minnesota, Minneapolis

56601

Sanford Health Bemidji, Bemidji

57105

Sanford Health System, Sioux Falls

57701

Monument Health Rapid City Hospital, Inc., Rapid City

58102

Sanford Roger Maris Cancer Center, Fargo

58185

Uni Hospital Linkoeping; Dept. of Oncology, Linköping

58506

Sanford Health Bismarck, Bismarck

59101

Billings Clinic; Cancer Center, Billings

59804

Community Cancer Care, Missoula

60521

Sudarshan K. Sharma, MD, Ltd., Hinsdale

60612

Rush University Medical Center, Chicago

60637

Univ of Chicago, Chicago

63108

Washington University School of Medicine; Dept of Medicine/Div of Medical Oncology, St Louis

65199

HELIOS Dr. Horst Schmidt Kliniken Wiesbaden; Klinik für Gynäkologie und gynäkologische Onkologie, Wiesbaden

68114

Nebraska Methodist Hospital, Omaha

69120

Universitätsklinikum Heidelberg; Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg

69373

Centre Léon Bérard; Centre régional; le cancer Rhône-Alpes, Lyon

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70211

Kuopio University Hospital, Kuopio

70817

Woman's Hospital, Baton Rouge

70852

University Hospital Ostrava; Fakultní nemocnice, Ostrava-Poruba

72000

Ctr Jean Bernard Clin V. Hugo; Service d'Oncologie Méd, Le Mans

72100

Ospedale Antonio Perrino; Oncologia Medica, Brindisi

73104

University of Oklahoma; Stephenson Oklahoma Canc Ctr, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute, Tulsa

75063

Rocky Mountain Cancer Centers, LLP, Irving

75571

Hopital Des Diaconesses; Oncologie, Paris

75702

Texas Oncology- Northeast Texas, Tyler

76022

Texas Oncology, Bedford

76104

Texas Oncology, P.A. - Fort Worth, Fort Worth

77030

Houston Methodist Hospital, Houston

77060

Texas Oncology, P.A., The Woodlands

78240

Texas Oncology San Antonio Medical Center, San Antonio

78464

Klinikum Konstanz, Frauenklinik, Konstanz

78701

Dell Seton Medical Center at UT-Seton Infusion Center; Research Department, Austin

78731

Texas Oncology Cancer Center, Austin

79106

Universitätsklinikum Freiburg; Frauenklinik, Freiburg im Breisgau

80045

University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora

80131

Azienda Ospedaliera Universitaria Federico II, Napoli

ISTITUTO NAZIONALE TUMORI IRCCS FONDAZIONE G. PASCALE; Dipartimento Uro-Ginecologico, Napoli

81377

Klinikum der Universität München; Campus Großhadern; Klinik und Poliklinik für Frauenheilkunde, München

81675

Klinikum rechts der Isar der TU München; Klinik und Poliklinik für Frauenheilkunde, München

84112

Huntsman Cancer Institute; Oncology, Salt Lake City

84790

Dixie Medical Center, St. George

84918

Clinique Sainte Catherine; Hopital De Semaine, Avignon

85013

St. Joseph'S Hospital & Medical Center, Phoenix

85258

Arizona Oncology Associates, PC - HAL, Scottsdale

85710

Arizona Oncology - HOPE Wilmot, Tucson

87106

Southwest Gynecologic Oncology Associates, Inc., Albuquerque

University of New Mexico Cancer Center, Albuquerque

89075

Universitätsklinikum Ulm Am Michelsberg; Frauenklinik, Ulm

89106

Women's Cancer Center, Las Vegas

89511

Center of Hope, Reno

90033

LAC + USC Medical Center, Los Angeles

90095

UCLA - School of Medicine, Los Angeles

91342

Olive View/Ucla Medical Center, Sylmar

92093

Moores Cancer Center at UC San Diego Health, La Jolla

92108

Southern California Kaiser Permanente, San Diego

92210

Centre Rene Huguenin; CONSULT SPECIALISEES, Saint-Cloud

92868

The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange, Orange

UC Irvine Medical Center, Orange

94115

California Pacific Medical Center Research Institute, San Francisco

K. Permanente - San Fransisco, San Francisco

94158

University of California San Francisco Cancer Center, San Francisco

94305

Stanford University, Palo Alto

94596

Kaiser Permanente - Walnut Creek, Walnut Creek

94611

Kaiser Permanente - Oakland, Oakland

94805

Institut Gustave Roussy, Villejuif

95051

Kaiser Permanente - Santa Clara, Santa Clara

95661

Kaiser Permanente - Sacramento, Roseville

96826

Women's Cancer Center, Honolulu

97223

Northwest Cancer Specialists, P.C., Tigard

97477

Oncology Associates of Oregon, P.C.; Willamette Valley Cancer Institute, Springfield

98195

University of Washington Seattle Cancer Care Alliance, Seattle

100032

Peking Union Medical College Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

105229

N.N.Burdenko Main Military Clinical Hospital; Oncology Dept, Moscow

143423

Moscow City Oncology Hospital #62, Moscovskaya Oblast

150081

Harbin Medical University Cancer Hospital, Harbin

197022

St. Petersburg Oncology & Gynecology; City Clinical Oncology Dispensary, Saint Petersburg

200120

Fudan University Shanghai Cancer Center, Shanghai

210009

Zhongda Hospital Affiliated to Southeast University, Nanjing

210029

Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing

300052

Tianjin Central Hospital of Gynecology Obstetrics., Tianjin

310006

Women's hospital school of medicine Zhejiang University, Hangzhou

310022

Zhejiang Cancer Hospital, Zhejiang

400030

Chongqing Cancer Hospital, Chongqing

420029

Clinical Oncology Dispensary of Ministry of Health of Tatarstan, Kazan'

450008

Henan Cancer Hospital, Zhengzhou

510663

Sun Yet-sen University Cancer Center, Guangzhou

530021

Guangxi Cancer Hospital of Guangxi Medical University, Nanning

610066

West China Second University Hospital, Chengdu

3810101

Hillel Yaffe MC; Gynaecology, Hadera

4428164

Meir Medical Center; Obstetrics and Gynecology, Kfar Saba

5262100

Chaim Sheba Medical Center; Obstetrics and Gynecology, Ramat Gan

7610001

Kaplan Medical Center; Oncology Inst., Rehovot

9103102

Shaare Zedek Medical Center; Oncology Dept, Jerusalem

06810

Danbury Hospital, Danbury

06360

Eastern Connecticut Hematology and Oncology Associates; (ECHO), Norwich

04074

Maine Medical Partners Women's Health; Gyn-Oncology, Scarborough

02114

Massachusetts General Hospital, Boston

01199

Baystate Medical Center, Springfield

68198-0600

University of Nebraska Medical Center, Omaha

03756

Dartmouth Hitchcock Medical Center, Lebanon

07920

MSK @Basking Ridge, Basking Ridge

08103

Cooper Health System; MD Anderson Cancer Center, Camden

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

07748

Memorial Sloan Kettering Cancer Center; MSK Monmouth, Middletown

07753

Jersey Shore Med Ctr; OB/GYN, Neptune City

07666

Holy Name Hospital, Teaneck

10029-6574

Mount Sinai Downtown Chelsea Centre, New York

45203-0542

University of Cincinnati, Cincinnati

02905

Women & Infants Hospital, Providence

75390-9016

UT Southwestern Medical Center at Dallas; Department of Pathology, Dallas

77030-4009

The University of Texas MD Anderson Cancer Center, Houston

20560-120

Instituto Nacional de Cancer - INCa; Oncologia, Rio de Janeiro

01317-001

Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, São Paulo

779 00

Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc

120 00

Gynekologicko-porodnicka klinika, Prague

01307

Universitätsklinikum Dresden; Klinik für Frauenheilkunde und Geburtshilfe, Dresden

115 28

Alexandras Hospital; Dept. of Clin. Therapeutics, Athens Uni School of Medicine, Athens

455 00

Uni Hospital of Ioannina; Oncology Dept., Ioannina

145 64

Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept., Kifissia

265 04

University Hospital of Patras Medical Oncology, Pátrai

546 45

EUROMEDICA General Clinic of Thessaloniki; Medical Oncology Dept - Oncomedicare, Thessaloniki

00168

Policlinico A. Gemelli e C.I.C.; Area Salute della Donna, Rome

06123

Ospedale Silvestrini; Oncologia ed Ematologia, Perugia

466-8560

Nagoya University Hospital, Aichi

791-0280

National Hospital Organization Shikoku Cancer Center, Ehime

791-0295

Ehime University Hospital, Ehime

811-1395

NHO Kyushu Cancer Center, Fukuoka

812-8582

Kyushu University Hospital, Fukuoka

830-0011

Kurume University Hospital, Fukuoka

737-0023

Kure Medical Center, Hiroshima

003-0804

National Hospital Organization Hokkaido Cancer Center, Hokkaido

673-0021

Hyogo Cancer Center, Hyōgo

890-8520

Kagoshima University Hospital, Kagoshima

236-0004

Yokohama City University Hospital, Kanagawa

606-8507

Kyoto University Hospital, Kyoto

514-8507

Mie University Hospital, Mie

980-8574

Tohoku University Hospital, Miyagi

951-8520

Niigata University Medical & Dental Hospital, Niigata

028-3695

Iwate Medical University Hospital, Numakunai

541-8567

Osaka International Cancer Institute, Osaka

411-8777

Shizuoka Cancer Center, Shizuoka

105-8471

The Jikei University Hospital, Tokyo

113-8655

The University of Tokyo Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

160-8582

Keio University Hospital, Tokyo

0310

Oslo Universitetssykehus HF; Radiumhospitalet, Oslo

31-115

Centrum Onkologii Instytut im. M.Sklodowskiej-Curie; Klinika Ginekologii Onkologicznej, Krakow

60-569

Szpital Kliniczny im. Heliodora ?wi?cickiego UM w Poznaniu; Oddzia? Ginekologii Onkologicznej, Późna

70-111

Icu Spsk - 2, Szczecin

02-781

Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie;Klinika Ginekologii Onkologicznej, Warsaw

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

135-710

Samsung Medical Center, Seoul

07010

Hospital Universitario Son Espases, Palma de Mallorca

08028

Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica, Barcelona

171 76

Karolinska Hospital; Oncology - Radiumhemmet, Stockholm

01230

Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology, Adana

06100

Ankara University Medical Faculty; Medikal Onkoloji, Ankara

06490

Baskent Universitesi Ankara Hastanesi; T?bbi Onkoloji Bölümü, Ankara

All Listed Sponsors
collaborator

GOG Foundation

NETWORK

collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

lead

Hoffmann-La Roche

INDUSTRY

NCT03038100 - A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | Biotech Hunter | Biotech Hunter