Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

590

Participants

Timeline

Start Date

March 17, 2017

Primary Completion Date

March 21, 2024

Study Completion Date

March 21, 2024

Conditions
RET-altered Non Small Cell Lung CancerMedullary Thyroid CancerRET-altered Papillary Thyroid CancerRET-altered Colon CancerRET-altered Solid TumorsLung NeoplasmCarcinoma, Non-Small-Cell LungThyroid DiseasesThyroid NeoplasmThyroid Cancer, PapillaryCarcinoma, NeuroendocrineRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract DiseaseCarcinoma, BronchogenicBronchial NeoplasmsEndocrine System DiseasesEndocrine Gland NeoplasmHead and Neck NeoplasmsAdenocarcinoma, PapillaryAdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeuroendocrine TumorsNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms, Nerve TissueColonic NeoplasmsColorectal NeoplasmsIntestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmDigestive System DiseaseGastrointestinal DiseaseColonic DiseasesIntestinal Disease
Interventions
DRUG

pralsetinib (BLU-667)

pralsetinib (BLU-667) is a potent and selective inhibitor of the RET mutations, fusions, and predicted resistant mutants

Trial Locations (71)

2650

Antwerp University Hospital, Edegem

6100

Centre Antoine Lacassagne, Nice

10002

National Taiwan University Hospital, Taipei

10021

Weill Cornell Medical College-New York Presbyterian Hospital, New York

11217

Taipei Veterans General Hospital, Taipei

14165

Helios Klinikum Emil von Behring GmbH, Berlin

20007

Georgetown University Medical Center, Washington D.C.

20141

IEO, Milan

20162

Asst Grande Ospedale Metropolitano Niguarda, Milan

26121

Pius-Hospital, Oldenburg

28034

Hospital Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

31059

Hôpital Larrey, Toulouse

32224

Mayo Clinic-Jacksonville, Jacksonville

33000

Institut Bergonie, Bordeaux

35033

CHU de Rennes - Hopital de Pontchaillo, Rennes

45122

Universitätsklinikum Essen, Essen

48100

Ospedale Santa Maria Delle Croci, Ravenna

59037

Centre Hospitalier Régional Universitaire de Lille (CHRU) - Hôpital Claude Huriez, Lille

69008

Centre Léon Bérard, Lyon

69126

Thoraxklinik Heidelberg gGmbH, Heidelberg

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75248

Institut Curie, Paris

80045

University of Colorado Anschutz Medical Campus, Aurora

81377

Klinikum der Universität München, München

85054

Mayo Clinic Hospital, Phoenix

92868

UC Irvine Medical Center, Orange

94800

Gustave Roussy, Villejuif

97239

Oregon Health & Science University, Portland

98109

Seattle Cancer Care Alliance, Seattle

100036

Beijing Cancer Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

123456

The Chinese University of Hong Kong, Shatin

169610

National Cancer Centre, Singapore

200032

Fudan University Shanghai Cancer Center, Shanghai

200120

Fudan University Shanghai Cancer Center, Shanghai

250013

Jinan Central Hospital, Jinan

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjing

310022

Zhejiang Cancer Hospital, Hangzhou

341000

First Affiliated Hospital of Gannan Medical University, Ganzhou

350014

Fujian Provincial Cancer Hospital, Fuzhou

400030

Chongqing Cancer Hospital, Chongqing

430023

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

510060

Sun Yet-sen University Cancer Center, Guangzhou

510080

Guangdong General Hospital, Guangzhou

610041

The affiliated Cancer Hospital, School of Medicine, UESTC, Chengdu

West China Hospital, Sichuan University, Chengdu

730050

Gansu Cancer Hospital, Lanzhou

33136-1002

Sylvester Comprehensive Cancer Center, Miami

21044-3257

Maryland Oncology Hematology, P.A., Columbia

02114-2696

Massachusetts General Hospital., Boston

48109-0934

University of Michigan, Ann Arbor

55902-3003

Mayo Clinic Rochester, Rochester

63110-1010

Washington University School of Medicine in St. Louis, St Louis

12208-3412

Albany Medical Center, Albany

78705-1165

Texas Oncology-Austin Midtown, Austin

77030-4000

The University of Texas MD Anderson Cancer Center, Houston

00144

Istituto Nazionale Tumori Regina Elena, Rome

1066 CX

Antoni van Leeuwenhoek Ziekenhuis, Amsterdam

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

120-752

Severance Hospital, Yonsei University Health System, Seoul

08908

Institut Catala d Oncologia Hospitalet, L'Hospitalet de Llobregat

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

SE1 9RT

Guys and St Thomas NHS Foundation Trust, Guys Hospital, London

W1T 7HA

University College London Hospitals NHS Foundation Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03037385 - Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors | Biotech Hunter | Biotech Hunter