748
Participants
Start Date
February 7, 2017
Primary Completion Date
November 20, 2019
Study Completion Date
November 20, 2019
Placebo for dexamethasone
Placebo for dexamethasone PO twice daily on Day -1, Day 1 (the day of dosing), and Day 2 of each 6 week cycle, omitting every third cycle.
Placebo for rovalpituzumab tesirine
Placebo for rovalpituzumab tesirine administered intravenously Day 1 of each 6-week cycle, omitting every third cycle
Rovalpituzumab tesirine
Rovalpituzumab tesirine 0.3 mg/kg administered intravenously Day 1 of each 6-week cycle, omitting every third cycle
Dexamethasone
Dexamethasone 8 mg administered orally (PO) twice daily on Day -1, Day 1 (the day of dosing), and Day 2 of each 6 week cycle, omitting every third cycle.
Dalin Tzu Chi General Hospital /ID# 158983, Dalin Township
Queen Elizabeth Hospital /ID# 159565, Kowloon
CHU Saint-Pierre /ID# 159009, Brussels
Semmelweis Egyetem /ID# 158955, Budapest
Orszagos Koranyi Pulmonologiai Intezet /ID# 158953, Budapest XII
SMZ Baumgartner Höhe, Otto-Wagner-Spital und Pflegezentrum /ID# 201776, Vienna
Hopitaux Universitaires de Geneve /ID# 160603, Geneva
Krankenhaus Nord - Klinik Floridsdorf /ID# 201768, Vienna
Akershus universitetssykehus /ID# 201682, Nordbyhagen
UMHAT Tsaritsa Joanna - ISUL /ID# 159638, Sofia
UMHAT Sv. Ivan Rilski /ID# 159639, Sofia
ZNA Middelheim /ID# 159007, Antwerp
Royal North Shore Hospital /ID# 158881, Saint Leonards
Rigshospitalet /ID# 158055, Copenhagen Ø
Gosford Hospital /ID# 158884, Gosford
Newcastle Private Hospital /ID# 203506, Lambton Heights
Coffs Harbour Hospital /ID# 158880, Coffs Harbour
Herlev Hospital /ID# 158053, Herlev
Drammen Sykehus /ID# 159572, Drammen
Sunshine Hospital /ID# 161700, St Albans
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 158962, Miskolc
Stavanger Universitetssykehus /ID# 159575, Stavanger
Ordensklinikum Linz GmbH, Elisabethinen /ID# 159564, Linz
Universitaetsspital Basel /ID# 160605, Basel
The Oncology Centre /ID# 158872, Durban
Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz - Pulmonologia /ID# 202466, Nyíregyháza
Odense Universitets Hospital /ID# 158054, Odense C
Calvary North Adelaide Hospita /ID# 161701, Adelaide
Salzburger Landeskliniken (SALK) /ID# 201779, Salzburg
Haukeland University Hospital /ID# 159573, Bergen
Grand Hôpital de Charleroi /ID# 159006, Charleroi
Luzerner Kantonsspital /ID# 160607, Lucerne
Affinity Clinical Research Ser /ID# 158887, Nedlands
Cancercare Langenhoven Drive Oncology Centre /ID# 159126, Port Elizabeth
CHU Charleroi (Vesale) /ID# 159008, Montigny-le-Tilleul
Cancercare Outeniqua Oncology Unit /ID# 200689, George
Csongrad Megyei Mellkasi Beteg /ID# 158952, Deszk
St. Olavs Hospital HF /ID# 163110, Trondheim
Hopital de Jolimont /ID# 159005, Haine-Saint-Paul
Cape Town Oncology Trials /ID# 201311, Cape Town
LKH-Univ. Klinikum Graz /ID# 159563, Graz
Kantonsspital Winterthur /ID# 161379, Winterthur
Aalborg University Hospital /ID# 203737, Aalborg
Kantonsspital St. Gallen /ID# 160604, Sankt Gallen
Klinicki bolnicki centar Sestre milosrdnice /ID# 159090, Zagreb
Klinika za plucne bolesti Jordanovac /ID# 159505, Zagreb
National Taiwan Univ Hosp /ID# 159049, Taipei City
Icahn School of Med Mt. Sinai /ID# 159210, New York
A.O.U. San Luigi Gonzaga /ID# 158916, Orbassano
Charite Universitatsmedizin Berlin Campus Virchow Klinikum /ID# 158783, Berlin
East Tallinn Central Hospital /ID# 160019, Tallinn
Montefiore Medical Center /ID# 201845, The Bronx
Clinical Center Serbia /ID# 160902, Belgrade
Institut za onkologiju i radio /ID# 160904, Belgrade
Northwell Health - Monter Cancer Center /ID# 159252, Lake Success
Clin Hosp Ctr Bezanijska Kosa /ID# 160903, Belgrade
Taipei Veterans General Hosp /ID# 203699, Taipei
Tri-Service General Hospital /ID# 158980, Taipei City
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159160, Athens
Evangelische Lungenklinik Berl /ID# 158935, Berlin
North Estonian Medical Centre /ID# 159779, Tallinn
CHA Bundang Medical center CHA University /ID# 161281, Seongnam-si
CHU Hopital Nord /ID# 160543, Marseille
General Oncological Hospital /ID# 159159, Nea Kifissia
Hospital Teresa Herrera - CHUAC /ID# 164368, A Coruña
VA Pittsburgh HealthcareSystem /ID# 159284, Pittsburgh
Metropolitan General Hospital /ID# 202422, Cholargós
Karolinska Univ Sjukhuset /ID# 159649, Solna
Clinical Center of Nis /ID# 160905, Niš
Metropolitan Hospital /ID# 159157, Athens
Christiana Care Health Service /ID# 159212, Newark
Institute For Pulmonary Diseas /ID# 164250, Kamenitz
PE PMC Acinus, Medical and Diagnostic Center /ID# 165543, Kropyvnytskyi
West Virginia Univ School Med /ID# 156687, Morgantown
Cone Health /ID# 156689, Greensboro
Cone Health /ID# 163612, Greensboro
Eastern Carolina University /ID# 159264, Greenville
Hospital Clinico Universitario San Carlos /ID# 159706, Madrid
Hospital Universitario Fundacion Jimenez Diaz /ID# 159693, Madrid
Hospital Universitario La Paz /ID# 159692, Madrid
Chungbuk National University /ID# 159300, Cheongju-si
Hospital Regional de Malaga /ID# 164371, Málaga
Southeastern Regional Medical /ID# 163064, Newnan
Georgia Cancer Center /ID# 201894, Atlanta
Hopital Larrey /ID# 204290, Toulouse
Cancer Specialists of North Florida - Southpoint /ID# 156595, Jacksonville
University of Florida - Archer /ID# 155799, Gainesville
Holy Cross Hospital /ID# 156716, Fort Lauderdale
Hopital Haut-Lévêque /ID# 160547, Pessac
Bezmi alem Vakif Universitesi /ID# 202267, Istanbul
Klinikum Kassel /ID# 158786, Kassel
Istanbul Medeniyet Universites /ID# 200126, Istanbul
Hospital Pontchaillou /ID# 160544, Rennes
Ege University Medical Faculty /ID# 159243, Izmir
Dr. Suat Seren Gogus Has /ID# 159244, Izmir
Clearview Cancer Institute /ID# 156699, Huntsville
Thompson Cancer Survival Ctr /ID# 202460, Knoxville
Erciyes University Medical Fac /ID# 202269, Melikgazi
University of Louisville /ID# 156683, Louisville
China Medical University Hosp /ID# 158981, Taichung
Taichung Veterans General Hosp /ID# 159047, Taichung
Ashland-Bellefonte Cancer Ctr /ID# 202901, Ashland
Kyungpook National University Chilgok Hospital /ID# 159301, Daegu
Volyn Regional Medical Oncology Centre /ID# 159133, Lutsk
Inonu University /ID# 159245, Malatya
Gabrail Cancer Center Research /ID# 156667, Canton
University Hospital of Ioannin /ID# 159158, Ioannina
Goshen Center for Cancer Care /ID# 156682, Goshen
IRST IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori /ID# 160898, Meldola
Ospedale Santa Maria delle Cro /ID# 158911, Ravenna
Henry Ford Health System /ID# 156712, Detroit
Sparrow Regional Cancer Center, Sparrow Health System /ID# 156590, Lansing
Municipal institution Multifie /ID# 159130, Dnipro
Dong-A University Hospital /ID# 159305, Busan
Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 160016, Kaunas
Hospital Clinico Universitario Lozano Blesa /ID# 159709, Zaragoza
Klinicki bolnicki centar Rijeka /ID# 159504, Rijeka
AUSL 8 Arezzo Ospedale San Don /ID# 160897, Arezzo
Euromedica General Clinic /ID# 159156, Thessaloniki
Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 159864, Chernivtsi
Centro de Investigación Clinica Chapultepec /ID# 160965, Morelia
Lungenklinik Hemer /ID# 158790, Hemer
CHU Calmette /ID# 202706, Lille
NorthShore University HealthSystem - Evanston Hospital /ID# 156664, Evanston
Ingalls Memorial Hosp /ID# 156685, Harvey
Regional Center of Oncology /ID# 159132, Kharkiv
MidAmerica Division, Inc. /ID# 163530, Kansas City
Nouvel Hopital Civil (NHC) /ID# 204427, Strasbourg
Nebraska Hematology Oncology /ID# 156534, Lincoln
CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159131, Zaporizhzhia
Thoraxklinik Heidelberg gGmbH /ID# 158871, Heidelberg
Centre Leon Berard /ID# 160550, Lyon
Assaf Harofeh Medical Center /ID# 201883, Be’er Ya‘aqov
National Cheng Kung University Hospital /ID# 158799, Tainan City
University General Hospital of Heraklion PA.G.N.I /ID# 202409, Heraklion
Klinik Loewenstein GmbH /ID# 158870, Löwenstein
Uppsala University Hospital /ID# 159052, Uppsala
Parkland Health and Hosp Syste /ID# 170933, Dallas
Institut Curie /ID# 207514, Paris
Hopital Tenon /ID# 160541, Paris
Houston Methodist Hospital - Scurlock Tower /ID# 202323, Houston
Univ Medical Ctr Brackenridge /ID# 155798, Austin
Kaiser Permanente Lone Tree /ID# 159331, Lone Tree
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 158798, Kaohsiung City
Asklepios Fachkliniken M. Gaut /ID# 158789, Gauting
St. Luke's Mountain States Tumor Institute - Boise /ID# 156691, Boise
Soroka University Medical Center /ID# 159762, Beersheba
"Communal Nonprofit Enterprise Central City Clinical Hospital of Uzhhorod City /ID# 159865", Uzhhorod
Fachkliniken Wangen /ID# 160779, Wangen
LA Hem-Oncology Med Group /ID# 156717, Los Angeles
Icri /Id# 157765, Whittier
Hadassah /ID# 159763, Jerusalem
Ucsd /Id# 157764, La Jolla
Centre Hosp Intercommunal de Creteil /ID# 162686, Créteil
Marin Cancer Care /ID# 159207, Greenbrae
St Jude Hospital dba St Joseph /ID# 156526, Santa Rosa
Kaiser Permanente, NW /ID# 201793, Portland
Medical Oncology Associates /ID# 156715, Spokane
National Medical Research Cntr /ID# 169885, Moscow
Jilin Cancer Hosptial /ID# 204060, Changchun
Harbin Medical University Cancer Hospital /Id# 203638, Harbin
Arkhangelsk clinical oncology /ID# 159367, Arkhangelsk
PMI Euromedservice /ID# 159369, Pushkin
LLC BioEq Ltd. /ID# 159368, Saint Petersburg
OOO Centre of Palliative Medicine De Vita /ID# 206855, Saint Petersburg
N.N. Petrov Research Inst Onc /ID# 159370, Saint Petersburg
Jiangsu Province Hospital /ID# 205183, Nanjing
Mogilev Reg Clin Oncology Dis /ID# 159384, Mogilev
Bobruysk Interdistrict Onco. /ID# 169393, Babruysk
Smolensk Regional Onc Clin Dis /ID# 159372, Smolensk
State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159383, Lesnoy
Kaluga Regional Clinical Oncol /ID# 160180, Kaluga
Sir Run Run Shaw Hospital /ID# 206802, Jianggan Hangzhou
Zhejiang Cancer hospital /ID# 204640, Hangzhou
Fujian Provincial Cancer Hospital /ID# 204864, Fuzhou
LLC Novaya Clinica /ID# 205523, Pyatigorsk
Ogarev Mordovia State Univ /ID# 205742, Saransk
Hubei Cancer Hospital /ID# 202886, Wuhan
Henan Cancer Hospital /ID# 203983, Zhengzhou Henan
Henan Cancer Hospital /ID# 204636, Zhengzhou Henan
Clinical Onco Dispensary /ID# 159365, Omsk
Yunnan Cancer Hospital /ID# 204911, Kunming
4th Military Medical Universit /ID# 203986, Xi'an
First Affiliated Hospital of Xi'an Jiaotong University /ID# 203733, Xi'an
The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 203641, Ürümqi
Princess Margaret Hospital /ID# 162810, Lai Chi Kok
Tuen Mun Hospital /ID# 162435, Tuenmen
Yokohama City University Hospital /ID# 165746, Yokohama
Rambam Health Care Campus /ID# 202336, Haifa
Meir Medical Center /ID# 159761, Kfar Saba
Rabin Medical Center /ID# 159764, Petakh Tikva
Sheba Medical Center /ID# 159760, Ramat Gan
Tel Aviv Sourasky Medical Center /ID# 161467, Tel Aviv
Japanese Red Cross Okayama Hospital /ID# 165157, Okayama
University of South Alabama /ID# 160975, Mobile
Highlands Oncology Group /ID# 156722, Fayetteville
Palo Alto Veterans Institute for Research /ID# 203695, Palo Alto
Memorial Cancer Institute /ID# 156673, Hollywood
Memorial Cancer Institute /ID# 164052, Hollywood
Ochsner Clinic Foundation /ID# 159136, Baton Rouge
Mayo Clinic - Rochester /ID# 160181, Rochester
Billings Clinic /ID# 201788, Billings
MD Anderson Cancer Center at Cooper - Camden /ID# 156681, Camden
Stony Brook University Hospital /ID# 159272, Stony Brook
Duke University Medical Center /ID# 156706, Durham
Thomas Jefferson University /ID# 156719, Philadelphia
Rhode Island Hospital /ID# 160834, Providence
Sarah Cannon Research Institute-Chattanooga /ID# 202933, Chattanooga
Tennessee Oncology-Nashville Centennial /ID# 161168, Nashville
UT Southwestern Medical Center /ID# 157848, Dallas
Hospital Evangelico de Cachoei /ID# 159657, Cachoeiro de Itapemirim
Liga Norte Rio Grandense Cont. /ID# 159011, Natal
Associação Hospital de Caridade Ijuí - Centro de Tratamento de Cancer - CACON /ID# 159013, Ijuí
Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159661, Passo Fundo
Hospital Sao Lucas da PUCRS /ID# 159662, Porto Alegre
Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159012, Barretos
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159659, São José do Rio Preto
Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159658, Rio de Janeiro
British Columbia Cancer Agency /ID# 163721, Surrey
Brampton Civic Hospital /ID# 204425, Brampton
R.S. McLaughlin Durham Regional /ID# 170870, Oshawa
Princess Margaret /ID# 170868, Toronto
Windsor Regional Cancer Centre /ID# 170869, Windsor
Iucpq-Ul /Id# 159530, Québec
Thomayerova nemocnice /ID# 159062, Prague
Nemocnice Rudolfa a Stefanie /ID# 159655, Benešov
Nemocnice Horovice a.s. /ID# 161186, Hořovice
Vitkovicka nemocnice a. s. /ID# 161187, Ostrava
FN Plzen /ID# 204097, Pilsen
Oblastni Nemocnice Pribram /ID# 159654, Příbram
Docrates Cancer Center /ID# 159591, Helsinki
KH Martha-Maria Halle Dolau /ID# 158794, Halle
St. James's Hospital /ID# 159712, Dublin
Cork University Hospital /ID# 159715, Cork
St Vincent's University Hosp /ID# 161678, Dublin
Beaumont Hospital /ID# 159711, Dublin
University Hospital Limerick /ID# 159714, Limerick
University Hospital Waterford /ID# 159713, Waterford
Policlinico Universitario Campus Bio-Medico /ID# 160874, Rome
IFO Istituto Nazionale Tumori /ID# 158912, Rome
Aichi Cancer Center Hospital /ID# 164976, Nagoya
National Cancer Center Hospital East /ID# 165721, Kashiwa-shi
Kyushu University Hospital /ID# 165722, Fukuoka
Kurume University Hospital /ID# 164595, Kurume-shi
Kanazawa University Hospital /ID# 165127, Kanazawa
Kanagawa Cardiovascular and Respiratory Center /ID# 165015, Yokohama
Kansai Medical University Hospital /ID# 165054, Hirakata-shi
Kindai University Hospital /ID# 166395, Osaka-sayama-shi
Shizuoka Cancer Center /ID# 166272, Sunto-gun
Tokushima University Hospital /ID# 166105, Tokushima
National Cancer Center Hospital /ID# 166547, Chuo-ku
Showa University Hospital /ID# 165575, Shinagawa-ku
Wakayama Medical University /ID# 165946, Wakayama
Hyogo Cancer Center /ID# 165138, Akashi
National Hospital Organization Himeji Medical Center /ID# 165899, Himeji
Matsusaka City Hospital /ID# 166156, Matsusaka-shi MIE
Osaka City General Hospital /ID# 165714, Osaka
Hokkaido Cancer Center /ID# 165236, Sapporo
Sendai Kousei Hospital /ID# 166491, Sendai
Kanagawa Cancer Center /ID# 165814, Yokohama
Pauls Stradins Clinical /ID# 158715, Riga
Riga East Clinical University /ID# 158716, Riga
Klaipeda University Hospital /ID# 160018, Klaipėda
National Cancer Institute /ID# 160017, Vilnius
Health Pharma professional Ser /ID# 160734, Mexico City
Jeroen Bosch Ziekenhuis /ID# 158081, 's-Hertogenbosch
Meander Medisch Centrum /ID# 159064, Amersfoort
Rijnstate /ID# 159063, Arnhem
Amphia Ziekenhuis /ID# 159065, Breda
Catharina Ziekenhuis /ID# 158082, Eindhoven
Maastricht Universitair Medisch Centrum /ID# 161669, Maastricht
Universitair Medisch Centrum Utrecht /ID# 158083, Utrecht
Radiumhospitalet, OUS /ID# 159574, Oslo
Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 159604, Rzeszów
Wojewodzki Szpital Specjalisty /ID# 159603, Bytom
Szpitale Pomorskie Sp. z o.o /ID# 159605, Gdynia
Centro Hospitalar Lisboa Norte, EPE /ID# 159957, Lisbon
IPO Lisboa FG, EPE /ID# 159949, Lisbon
Hospital da Luz, SA /ID# 159954, Lisbon
Unidade Local Saude Matosinhos /ID# 159950, Matosinhos Municipality
Centro Hospitalar do Porto EPE /ID# 203582, Porto
Hospital CUF Porto /ID# 159955, Porto
IPO Porto FG, EPE /ID# 159956, Porto
Dr Albert, Bouwer and Jordaan Incorporated /ID# 158873, Pretoria
Mary Potter Oncology Centre /ID# 158877, Pretoria
Samsung Medical Center /ID# 159304, Seoul
Korea University Guro Hospital /ID# 159302, Seoul
Severance Hospital /ID# 159297, Seoul
Asan Medical Center /ID# 159299, Seoul
Hospital Parc de Salut del Mar /ID# 159690, Barcelona
Hospital Universitario Vall d'Hebron /ID# 159708, Barcelona
Centralsjukhuset, Karlstad /ID# 163451, Karlstad
Sahlgrenska US Gbg /ID# 159524, Gothenburg
University Hospital Linkoping /ID# 159046, Linköping
Hacettepe University Medical Faculty /ID# 159242, Altindağ
Ataturk Gogus Hastalikl /ID# 159556, Ankara
Akdeniz Universitesi Tip Fakul /ID# 160791, Antalya
Cheltenham General Hospital /ID# 169096, Cheltenham
Queen Elizabeth Medical Centre /ID# 162899, Birmingham
The Royal Bournemouth Hospital /ID# 159039, Bournemouth
Colchester General Hospital /ID# 159042, Colchester
Hereford County Hospital /ID# 159038, Hereford
St. George's Healthcare NHS /ID# 202416, London
Charing Cross Hospital /ID# 161399, London
Maidstone Hospital /ID# 159043, Maidstone
Christie NHS Foundation Trust /ID# 159037, Manchester
The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 159044, Newcastle upon Tyne
Torbay Hospital - So Devon HC /ID# 159041, Torquay
Lead Sponsor
AbbVie
INDUSTRY