Neurobiological and Cognitive Changes Following Exposure to Either Sevoflurane- or Propofol-based Anesthesia in Children

PHASE3CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

January 31, 2017

Primary Completion Date

September 30, 2019

Study Completion Date

September 30, 2019

Conditions
Cognitive ChangeBehavior
Interventions
DRUG

Propofol

The child will be randomized via a block design to receive either a volatile anesthetic (induction: sevoflurane), or total intravenous anesthetic technique (induction: propofol)

DRUG

Sevoflurane

The child will be randomized via a block design to receive either a volatile anesthetic (induction: sevoflurane), or total intravenous anesthetic technique (induction: propofol)

DRUG

Ametop

Each patient will receive Ametop local anesthetic to the dorsum of both hands 30-45 minutes prior to induction.

DRUG

Ondansetron

Each patient will receive the antiemetic ondansetron 0.1mg/kg IV.

Trial Locations (1)

T2N 1N4

University of Calgary, Calgary

All Listed Sponsors
lead

University of Calgary

OTHER

NCT03022240 - Neurobiological and Cognitive Changes Following Exposure to Either Sevoflurane- or Propofol-based Anesthesia in Children | Biotech Hunter | Biotech Hunter