Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

PHASE3CompletedINTERVENTIONAL
Enrollment

2,538

Participants

Timeline

Start Date

July 7, 2017

Primary Completion Date

March 14, 2025

Study Completion Date

March 14, 2025

Conditions
Endstage Renal Disease
Interventions
DRUG

Spironolactone 25Mg Tablet

Randomized participants will receive a study supply of spironolactone 25 mg tablets. They will be instructed to take 1 tablet daily.

DRUG

Placebo Oral Tablet

Randomized participants will receive a study supply of placebo tablets with no active medical ingredients. They will be instructed to take 1 tablet daily.

Trial Locations (141)

1000

Philippines General Hospital, Ermita

1101

National Kidney and Transplant Institute, Quezon City

2076

Royal North Shore Hospital, Wahroonga

Sydney Adventist Hospital, Wahroonga

2086

Northern Beaches Hospital, Frenchs Forest

2139

Concord Repatriation General Hospital, Concord

2605

Canberra Hospital, Garran

3021

Western Health - Sunshine Hospital, Saint Albans

3168

Monash Health, Clayton

3204

Waikato Hospital, Hamilton

4029

Royal Brisbane Women's Hospital, Herston

4102

Princess Alexandra Hospital, Woolloongabba

4120

Hawkes Bay Hospital, Hastings

4442

Palmerston North Hospital, Palmerston North

4575

Sunshine Coast University Hospital, Birtinya

9016

Dunedin Hospital, Dunedin

10990

Hospital Pulau Pinang, George Town

11800

SEDIC Center, Montevideo

25167

Hospital Tuanku Jaafar, Seremban, Seremban

29142

Hospital Tengku Ampuan Afzan, Kuantan, Kuantan

33158

Hospital Sultanah Nur Zahirah Kuala Terengganu, Kuala Terengganu

34000

Hospital Taiping, Taiping

41200

Hospital Tengku Ampuan Rahimah Klang, Klang

42896

Hospital Kuala Lumpur, Kuala Lumpur

43000

Hospital Kajang, Kajang

53200

Hospital Ampang, Setapak

59100

University Malaya Medical Centre (UMMC), Kuala Lumpur

80100

Hospital Sultanah Aminah, Johor Bahru, Johor Bahru

170303

Clinefnorte CIA Ltda, Quito

170601

Nefromedic SA, Quito

400016

National Health and Education Society, Mumbai

411004

ACE Hospital Une, Pune

411033

Aditya Birla Hospital, Pune

421004

Ashirwad Hospital Mumbai, Mumbai

421203

AIMS Hospital Mumbai, Dombivali

422002

Dhadiwal Hospital, Nashik

500012

Osmania General Hospital, Hyderabad

500082

Nizams Institute of Medical Sciences, Hyderabad

560076

Fortis Hospitals, Bengaluru

560099

Narayana Hrudayalaya Limited, Bangalore

575018

K S Hegde Medical Academy, Mangaluru

577201

Nanjappa Hospitals Shimoga, Shimoga

600003

Madras Medical College Chennai, Park Town

600026

Vijaya Hospital, Chennai

600081

Apollo Hospitals, Chennai

682027

AsterMedCity, Kochi

686630

Caritas Hospital, Kottayam

8835404

Hospital Arquidiocesano Consul Carlos Reneaux, Brusque

15500003

Santa Casa de Misericordia de Votuporanga, Votuporanga

30110934

Felicio Rocho Foundation - Hospital Felicio Rocho, Belo Horizonte

30150221

Santa Casa de Misericordia de Belo Horizonte, Santa Efigênia

31110580

Fundacao Hospitalar Sao Francisco de Assis, Belo Horizonte

36500008

Servico Ubaense de Nefrologia Ltda, Ubá

83430000

Sociedade Hospitalar Angelina Caron, Campina Grande do Sul

89010500

PROCARDIO Clinica Cardiologica, Blumenau

89227680

Fundacao Pro-Rim, Boa Vista

90020090

Irmandade da Santa Casa de Misericordia de Porto Alegre -ISCMPA, Bairro Santa Teresa

18618-687

Medical School of Botucatu of the Paulista State University - UNESP, Rubião Júnior

80440-020

Instituto Pro Renal Brazil, Curitiba

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

09090 790

Praxis Pesquisa Medica S/S, Santo André

Unknown

Hospital Alemao Oswaldo Cruz, Bela Vista

Santa Casa de Misericordia de Ponta Grossa, Ponta Grossa

Penticton Regional Hospital, Penticton

Cape Breton Regional Hospital, Sydney

Queens University at Kingston General Hospital, Division of Nephrology, Kingston

Humber River Health, Toronto

The Sir Mortimer B. Davis Jewish General Hospital, Montreal

Peking University First Hospital, Beijing

Peking University Peoples Hospital, Beijing

General Hospital of Ningxia Medical University, Yinchuan

The First Affiliated Hospital of Baotou Medical College, Baotou

Beijing Miyun District Hospital, Beijing

Beijing Tongren Hospital, Capital Medical University, Beijing

Emergency General Hospital, Beijing

Faw General Hospital of Jilin Province, Changchun

The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi

Huai'an First Peoples Hospital, Huai'an

The First Hospital of Kunming, Kunming

Gansu Baoshihua Hospital, Lanzhou

Yichuan County Traditional Chinese Medicine Hospital, Luoyang

Shanghai Tongji Hospital, Shanghai

Shanxi Provincial Peoples Hospital, Shanxi

Shuyang County Hospital of Traditional Chinese Medicine, Suqian

Sihong County Fenjinting Hospital, Suqian

Tianjin Fifth Central Hospital, Tianjin

Tianjin Third Central Hospital, Tianjin

Tongiao City Hospital, Tongliao

Xinxiang First Peoples Hospital, Xinxiang

General Hospital of Xuzhou Mining Group, Xuzhou

Peoples Hospital of Yuxi City, Yuxi

Peoples Hospital of Zhongwei, Zhongwei

Government Rajaji Hospital, Madurai, Madurai

Father Muller Medical College, Mangalore

Seven Star Hospital, Nagpur

Hospital Pakar Sultanah Fatimah, Muar town

Hacettepe University Hospitals Hemodialysis Center, Ankara

Osmangazi University, Eskişehir

Memorial Service Hospital, Istanbul

Birmingham Hospitals, Birmingham

Epsom St. Helier, Carshalton

Leicester General Hospital, Leicester

Liverpool University Hospitals, Liverpool

South Tees James Cook Hospital, Middlesbrough

Royal Stoke University Hospital, Stoke-on-Trent

Canimel Center, Melo

Cedina Center, Montevideo

Centro de Asistencia del Sindicato Medico del Uruguay-Institucion de Asistencia medica Privada (CASMU-IAMPP), Montevideo

T2N 2T9

Foothills Hospital, Calgary

T6G 2G3

University of Alberta, Edmonton

V2C 2T1

Royal Inland Hospital, Kamloops

V1Y 1T2

Kelowna General Hospital, Kelowna

V6Z 1Y6

St. Pauls Hospital, Vancouver

B3H 1V7

Queen Elizabeth II Health Science Centre, Halifax

P3E 5J1

Health Sciences North Research Institute, Greater Sudbury

L8N 4A6

St. Joseph's Healthcare, Hamilton

N6A 5W9

Victoria Hospital, London

K1Y 4E9

Ottawa Hospital Research Institute, Ottawa

M5B 1W8

St. Michael's Hospital, Toronto

M6R 1B5

St. Josephs, Toronto, Toronto

H1T 2M4

CIUSSS Hopital Maisonneuve- Rosemont, Montreal

H2W 1T8

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal

H4J 1C5

Hopital du Sacre-Coeur de Montreal, Montreal

G1R 2J6

CHU de Quebec L'Hotel-Dieu de Quebec, Québec

0620

North Shore Hospital, Takapuna

0148

Whangarei Hospital, Whangarei

BT16 1RH

Ulster Hospital, Dundonald

BS10 5NB

Southmead Hospital, Bristol

CF14 4XW

University Hospital of Whales Health Park, Cardiff

BT35 8DR

Daisy Hill Hospital, Newry

G51 4TF

Queen Elizabeth University Hospital, Glasgow

CT1 3NG

East Kent Canterbury Hospital, Canterbury

E1 2ES

The Royal London Hospital, London

SE5 9RS

Kings College Hospital, London

NG5 1PB

City Hospital, Nottingham

OX3 7LE

Churchill Hospital, Headington

M6 8HD

Salford Royal Hospital, Salford

AB23 2ZN

Aberdeen Royal Infirmary, Aberdeen

BT9 7AB

Belfast City Hospital, Belfast

DE22 3NE

Royal Derby Hospital, Derby

DD1 9SY

Ninewells Hospital, Dundee

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Population Health Research Institute

OTHER