26
Participants
Start Date
October 16, 2017
Primary Completion Date
October 1, 2019
Study Completion Date
August 24, 2021
CAR-20/19-T cells (1.0 x10^5 CAR-20/19-T cells/kg)
"CAR-20/19-T cells will be administered either fresh or thawed after cryopreservation by IV injection.~Phase 1 Dose Level 0: 2.5 x10\^5 CAR-20/19-T cells/kg (starting dose level)"
CAR-20/19-T cells (2.5 x10^5 CAR-20/19-T cells/kg)
"CAR-20/19-T cells will be administered either fresh or thawed after cryopreservation by IV injection.~Phase 1 Dose Level 1: 7.5 x10\^5 CAR-20/19-T cells/kg"
CAR-20/19-T cells (7.5 x10^5 CAR-20/19-T cells/kg)
"CAR-20/19-T cells will be administered either fresh or thawed after cryopreservation by IV injection.~Phase 1 Dose Level 2: 2.5 x10\^6 CAR-20/19-T cells/kg (goal cell dose)~Phase 1b Expansion Dose Level: 2.5 x 10\^6 cells/kg (single infusion)"
CAR-20/19-T cells (2.5 x10^6 CAR-20/19-T cells/kg)
CAR-20/19-T cells will be administered either fresh or thawed after cryopreservation by IV injection.
Froedtert Hospital & Medical College of Wisconsin, Milwaukee
Children's Hospital and Health System Foundation, Wisconsin
OTHER
Medical College of Wisconsin
OTHER