Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder (CLARITY)

PHASE2CompletedINTERVENTIONAL
Enrollment

207

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

September 30, 2018

Study Completion Date

October 31, 2018

Conditions
Adjunctive Treatment of Major Depressive Disorder
Interventions
DRUG

Pimavanserin

Pimavanserin 34 mg, tablet, taken as two 17 mg tablets, once daily by mouth All patients continued to receive selective serotonin reuptake inhibitor/serotonin norepinephrine reuptake inhibitor (SSRI/SNRI) antidepressants at a stable dose for the duration of the study.

OTHER

Placebo

Placebo, taken as two tablets, once daily by mouth All patients continued to receive selective serotonin reuptake inhibitor/serotonin norepinephrine reuptake inhibitor (SSRI/SNRI) antidepressants at a stable dose for the duration of the study.

Trial Locations (36)

10036

Manhattan Behavioral Medicine, New York

14618

Finger Lakes Clinical Research, Rochester

19104

UPenn, Philadelphia

29407

Carolina Clinical Trials, Inc., Charleston

30030

iResearch Atlanta, Decatur

30329

Emory University School of Medicine, Atlanta

32256

CNS Health care (Jacksonville), Jacksonville

32751

Meridien Research, Maitland

32801

CNS Health care (Orlando), Orlando

34201

Meridien Research, Bradenton

35294

UAB, Birmingham

44718

Neuro-Behavioral Clinical Research, Canton

53188

IPC Research, Waukesha

60169

Alexian Brothers Center for Psychiatric Research, Hoffman Estates

60612

Alam Medical Research, INC, Chicago

63141

St. Louis Clinical Trials, St Louis

67214

KUMC, Wichita

72758

Woodland Research Northwest, Rogers

73103

IPS Research, Oklahoma City

73112

Rivus Wellness & Research Institute, Oklahoma City

75080

Pillar Clinical Research, Richardson

75231

FutureSearch Trials of Dallas, L.P., Dallas

75235

UTSW, Dallas

77030

Baylor College of Medicine, Houston

84015

Ericksen Research & Development, Clinton

89102

Altea Research, Las Vegas

90502

Collaborative Neuroscience Network, LLC, Torrance

91403

Schuster Medical Research Institute, Sherman Oaks

91786

Pacific Clinical Research Medical Group, Upland

91950

Synergy San Diego, National City

92591

Viking Clinical Research, Temecula

92845

Collaborative Neuroscience Network, LLC, Garden Grove

94607

Pacific Research Partners, LLC, Oakland

97210

Summit Research Network (Oregon), Portland

08009

Hassman Research Institute, Berlin

02865

BTC of Lincoln, Lincoln

Sponsors
All Listed Sponsors
lead

ACADIA Pharmaceuticals Inc.

INDUSTRY