A Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Enzalutamide in Participants With Metastatic Castration-Resistant Prostrate Cancer (mCRPC) After Failure of an Androgen Synthesis Inhibitor And Failure of, Ineligibility For, or Refusal of a Taxane Regimen

PHASE3CompletedINTERVENTIONAL
Enrollment

759

Participants

Timeline

Start Date

January 10, 2017

Primary Completion Date

June 24, 2019

Study Completion Date

December 20, 2022

Conditions
Prostatic Neoplasms, Castration-Resistant
Interventions
DRUG

Atezolizumab

Atezolizumab will be administered at a fixed dose of 1200 milligrams (mg), intravenous (IV) infusion on Day 1 of each 21-day cycle.

DRUG

Enzalutamide

Enzalutamide capsules will be administered orally at a dose of 160 mg daily.

Trial Locations (158)

333

Chang Gung Memorial Hospital-LinKou; Urology, Taoyuan District

407

Taichung Veterans General Hospital; Division of Urology, Taichung

1082

Semmelwies University of Medicine; Urology Dept., Budapest

1090

Medizinische Universität Wien; Universitätsklinik für Urologie, Vienna

1122

"Orszagos Onkologiai Intezet; C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály", Budapest

2113

Macquarie University Hospital, Macquarie Park

2139

Concord Repatriation General Hospital; Concord Cancer Centre, Concord

2730

Herlev Hospital; Afdeling for Kræftbehandling, Herlev

3010

Inselspital Bern; Universitätsklinik für Medizinische Onkologie, Klinische Forschungseinheit, Bern

3128

Eastern Health; Cancer Services, Box Hill

3168

Monash Medical Centre; Oncology, Clayton

4000

CHU Sart-Tilman, Liège

4020

Ordensklinikum Linz Elisabethinen; Abteilung für Urologie und Andrologie, Linz

4029

Royal Brisbane & Women's Hosp; Cancer Care Serv, Herston

4032

Debreceni Egyetem Klinikai Kozpont ; Department of Oncology, Debrecen

5000

Odense Universitetshospital, Onkologisk Afdeling R, Odense C

5037

Adelaide Cancer Centre, Kurralta Park

8036

LKH-UNIV. KLINIKUM GRAZ; Klinische Abteilung für Onkologie, Graz

8208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

9000

UZ Gent, Ghent

Aalborg Universitetshospital; Onkologisk Afdeling, Aalborg

9007

Kantonsspital St. Gallen; Onkologie/Hämatologie, Sankt Gallen

9300

Onze Lieve Vrouwziekenhuis Aalst, Aalst

10032

Columbia University Medical Center, New York

10048

National Taiwan University Hospital, Department of Urology, Taipei

10065

Memorial Sloan-Kettering Cancer Center, New York

10408

National Cancer Center, Goyang-si

11217

TAIPEI VETERANS GENERAL HOSPITAL, Urology, Taipei

12208

New York Oncology Hematology, P.C., Albany

14004

Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba

14076

Centre Francois Baclesse; Oncologie, Caen

15212

Allegheny Cancer Center, Pittsburgh

15232

University of Pittsburgh Cancer Institute; Division of Medical Oncology, Pittsburgh

16132

IRCCS AOU San Martino - IST; Oncologia Medica 1, Genoa

17033

Penn State Milton S. Hershey Medical Center, Hershey

20133

Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2, Milan

20141

Irccs Istituto Europeo Di Oncologia (IEO); Cure Mediche, Milan

20850

Associates in Oncology/Hematology P.C., Rockville

22304

Virginia Cancer Specialists - Alexandria, Alexandria

23502

Virginia Oncology Associates, Norfolk

26100

A.O. Istituti Ospitalieri - Cremona; S.C. Oncologia, Cremona

28034

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid

28040

Hospital Clinico San Carlos; Servicio de Oncologia, Madrid

28041

Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid

29010

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga

29414

Charleston Oncology, P .A, Charleston

29572

Carolina Urologic Research Center, Myrtle Beach

30625

Medizinische Hochschule Hannover; Klinik für Urologie und Onkologische Urologie, Hanover

31008

Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona

31059

Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse

33176

Miami Cancer Institute of Baptist Health, Inc., Miami

33486

Lynn Cancer Institute/Boca Raton Regional Hospital, Boca Raton

33705

Florida Cancer Specialist, North Region, St. Petersburg

33916

SCRI Florida Cancer Specialists South, Fort Myers

35128

IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima, Padua

37404

Sarah Cannon Research Institute / Tennessee Oncology, Chattanooga

41013

Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Seville

41124

A.O. Universitaria Policlinico Di Modena; Oncologia, Modena

43210

James Cancer Hospital;Solove Research Institute, Columbus

45230

Oncology Hematology Care, Inc., Cincinnati

46260

Investigative Clin Rsch of IN, Indianapolis

48149

Universitätsklinikum Münster, Klinik für Urologie und Kinderurologie, Münster

48201

Karmanos Cancer Institute.., Detroit

52100

Ospedale Area Aretina Nord; U.O.C. Oncologia, Arezzo

52146

Urologisches Zentrum Euregio; Würselen, Urologische Praxis am Wasserturm, Würselen

59000

Centre Oscar Lambret; Chir Cancerologie General, Lille

68024

Hopital Louis Pasteur; Medecine B, Colmar

68130

Nebraska Cancer Specialists; Oncology Hematology West, PC, Omaha

Urology Cancer Center & GU Research Network, Omaha

70124

Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica, Bari

71013

IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia, San Giovanni Rotondo

72076

Universitätsklinikum Tübingen; Klinik für Urologie, Tübingen

75063

Texas Oncology-Tyler, Irving

75203

Texas Oncology - Methodist Dallas Cancer Center, Dallas

75475

Hopital Saint Louis, Service D Oncologie Medicale, Paris

76104

Texas Oncology, P.A. - Fort Worth, Fort Worth

77024

Texas Oncology - Memorial City, Houston

78731

Texas Oncology Cancer Center, Austin

79106

Universitätsklinikum Freiburg; Chirurgische Klinik; Abteilung Urologie, Freiburg im Breisgau

80021

University of Colorado; Division of Medical Oncology, Aurora

80131

ISTITUTO NAZIONALE TUMORI IRCCS FONDAZIONE G. PASCALE; Dipartimento Uro-Ginecologico, Napoli

84082

Institut Sainte-Catherine; Oncologie, Avignon

87039

Clinique Chenieux; Oncology, Limoges

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

90027

Kaiser Permanente San Diego - Los Angeles, Los Angeles

91010

City of Hope Medical Grp Inc., Duarte

92868

UC Irvine Medical Center, Orange

94115

Pacific Hematology Oncology Associates, San Francisco

94160

Hopital d'Instruction des Armees de Begin, Saint-Mandé

94805

Institut Gustave Roussy, Villejuif

100050

Friendship Hospital, Capital Medical University, Beijing

117997

Russian Scientific Center of Roentgenoradiology, Moscow

125248

P.A. Herzen Oncological Inst. ; Oncology, Moscow

197022

"SBEI HPE The First St.Petersburg State Medical University n.a. acad. I.P.Pavlovaof MoH of RF", Saint Petersburg

200032

Zhongshan Hospital Fudan University, Shanghai

200120

Fudan University Shanghai Cancer Center, Shanghai

211100

Jiangsu Cancer Hospital, Nanjing

92037-1337

University of California San Diego, La Jolla

06510-3206

Yale School of Medicine, New Haven

06904

Stamford Hospital; BCC, MOHR, Stamford

02215

Dana-Farber Cancer Institute, Boston

07920

MSKCC at Basking Ridge, Basking Ridge

02906

Miriam Hospital, Providence

T2N 4N2

Tom Baker Cancer Centre-Calgary, Calgary

K7L 2V7

Kingston General Hospital, Kingston

L1G 2B9

Lakeridge Health Oshawa; Oncology, Oshawa

M5G 1Z5

Princess Margaret Cancer Center, Toronto

J4V 2H1

Hopital Charles Lemoyne; Centre Integre de Lutte Contre Le Cancer de La Monteregie, Greenfield Park

H3T 1E2

Jewish General Hospital, Montreal

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke - Hopital Fleurimont, Sherbrooke

G1J 1Z4

CHU de Québec - Université Laval - Hôtel-Dieu de Québec, Québec

656 53

Masarykuv onkologicky ustav, Brno

656 91

Fakultni nemocnice u sv. Anny v Brne, Brno

140 59

Thomayerova nemocnice, Praha 4 - Krc

115 22

Anticancer Hospital Ag Savas; 1St Dept of Internal Medicine, Athens

115 28

Alexandras Hospital; Dept. of Clin. Therapeutics, Athens Uni School of Medicine, Athens

151 25

Athens Medical Center; Dept. of Oncology, Athens

155 62

IASO General Hospital of Athens, Athens

145 64

Agioi Anargyroi Cancer Hospital; 2Nd Oncology Dept., Kifissia

265 04

University Hospital of Patras Medical Oncology, Pátrai

564 29

Papageorgiou General Hospital; Medical Oncology, Thessaloniki

00152

Azienda Ospedaliera San Camillo Forlanini; Oncologia Medica, Rome

467-8602

Nagoya City University Hospital, Aichi

277-8577

National Cancer Center East, Chiba

285-8741

Toho University Sakura Medical Center, Chiba

812-8582

Kyushu University Hospital, Fukuoka

003-0804

National Hospital Organization Hokkaido Cancer Center, Hokkaido

232-0024

Yokohama City University Medical Center, Kanagawa

252-0375

Kitasato University Hospital, Kanagawa

602-8566

University Hospital Kyoto Prefectural University of Medicine, Kyoto

634-8522

Nara Medical University Hospital, Nara

951-8520

Niigata University Medical & Dental Hospital, Niigata

573-1191

Kansai Medical University Hospital, Osaka

105-8470

Toranomon Hospital, Tokyo

105-8471

The Jikei University Hospital, Tokyo

113-8603

Nippon Medical School Hospital, Tokyo

93-513

Woj. Wielospec. Centrum Onkologii i Traumatologii, ?ód?

15-027

Medical University of Bialystok; Oncology clinic, Bialystok

62-500

Przychodnia Lekarska KOMED, Roman Karaszewski, Konin

30-688

Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow

45-061

SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarawskiego, Opole

05-400

Europejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii, Otwock

02-616

Szpital Sw. Elzbiety - Mokotowskie Centrum Medyczne Sp. z o.o., Warsaw

51-124

Wojewodzki Szpital; Specjalistyczny ul., Wroclaw

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08916

Institut Catala d?Oncologia Hospital Germans Trias i Pujol, Badalona

08908

Insititut Catala D'Oncologia, L'Hospitalet de Llobregat

08035

Hospital Universitari Vall d'Hebron; Oncology, Barcelona

08036

Hospital Clínic i Provincial; Servicio de Oncología, Barcelona

08041

Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia, Barcelona

BB2 3HH

Royal Blackburn Hospital, Blackburn

LE1 5WW

Leicester Royal Infirmary, Leicester

EC1A 7BE

Barts and the London NHS Trust., London

W1G 6AD

Sarah Cannon Research Institute, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

SM2 5PT

Royal Marsden Hospital; Institute of Cancer Research, Sutton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03016312 - A Study of Atezolizumab (Anti-PD-L1 Antibody) in Combination With Enzalutamide in Participants With Metastatic Castration-Resistant Prostrate Cancer (mCRPC) After Failure of an Androgen Synthesis Inhibitor And Failure of, Ineligibility For, or Refusal of a Taxane Regimen | Biotech Hunter | Biotech Hunter