1,500
Participants
Start Date
January 6, 2017
Primary Completion Date
December 11, 2024
Study Completion Date
December 11, 2024
Dexmedetomidine supplemented morphine analgesia
Patients in this group receive patient-controlled intravenous analgesia for 3 days after surgery. The formula is a mixture of dexmedetomidine (1.25 ug/ml) and morphine (0.5 mg/ml), diluted with normal saline to 160 ml. 5-HT3 receptor antagonist is added when necessary. The analgesic pump is set to administer a background infusion at a rate of 1 ml/h, with a bolus dose of 2 ml at each time and a lockout time from 6 to 8 minutes.
Morphine analgesia
Patients in this group receive patient-controlled intravenous analgesia for 3 days after surgery. The formula is morphine (0.5 mg/ml), diluted with normal saline to 160 ml. 5-HT3 receptor antagonist is added when necessary. The analgesic pump is set to administer a background infusion at a rate of 1 ml/h, with a bolus dose of 2 ml at each time and a lockout time from 6 to 8 minutes.
Peking University First Hospital, Beijing
Affiliated Hospital of Hebei University
OTHER
Qingdao Municipal Hospital
OTHER
The Second Affiliated Hospital of Air Force Medical University
UNKNOWN
Beijing Chao Yang Hospital
OTHER
Beijing Shijitan Hospital, Capital Medical University
OTHER
Beijing Tsinghua Chang Gung Hospital
OTHER
Peking University International Hospital
OTHER
Beijing Ditan Hospital
OTHER
Guizhou Provincial People's Hospital
OTHER
The Third Xiangya Hospital of Central South University
OTHER
Shaanxi Provincial Cancer Hospital
OTHER
Tianjin Hospital of ITCWM-Nankai Hospital
UNKNOWN
Zhongda Hospital
OTHER
Peking University First Hospital
OTHER