843
Participants
Start Date
January 22, 2018
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
Rifampin
Subjects who are randomly assigned to adjunctive rifampin will receive a 600 mg oral daily dose targeted for a six-week period. If a subject experiences gastrointestinal intolerance on once daily dosing, the study drug may be administered as rifampin 300 mg twice a day.
Riboflavin Placebo
A placebo capsule will be administered daily to match frequency and duration of rifampin interventional drug. For the purpose of mimicking urine discoloration when taking rifampin, riboflavin will be added to the placebo to produce a urine discoloration effect.
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC, Salisbury
Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur
Miami VA Healthcare System, Miami, FL, Miami
James A. Haley Veterans' Hospital, Tampa, FL, Tampa
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
Dayton VA Medical Center, Dayton, OH, Dayton
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Oklahoma City VA Medical Center, Oklahoma City, OK, Oklahoma City
Michael E. DeBakey VA Medical Center, Houston, TX, Houston
South Texas Health Care System, San Antonio, TX, San Antonio
Phoenix VA Health Care System, Phoenix, AZ, Phoenix
VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
VA Long Beach Healthcare System, Long Beach, CA, Long Beach
VA Northern California Health Care System, Mather, CA, Sacramento
VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda
VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora
Washington DC VA Medical Center, Washington, DC, Washington D.C.
Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines
North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville
VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor
James J. Peters VA Medical Center, Bronx, NY, The Bronx
Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
VA Portland Health Care System, Portland, OR, Portland
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN, Nashville
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
Salem VA Medical Center, Salem, VA, Salem
William S. Middleton Memorial Veterans Hospital, Madison, WI, Madison
VA Office of Research and Development
FED