272
Participants
Start Date
February 13, 2017
Primary Completion Date
December 31, 2019
Study Completion Date
May 1, 2020
Human tetanus immunoglobulin
Adults admitted to ICU at Hospital for Tropical Diseases will be randomized to receive either human (3000 IU) or equine (21,000 units) intramuscular antitoxin. Second, participants will be randomized to receive the addition of 500 IU intrathecal human antitoxin.
Intramuscular antitoxin
First, adults admitted to ICU at Hospital for Tropical Diseases will be randomized to receive either human (3000 IU) or equine (21,000 units) intramuscular antitoxin including a 0.05ml test dose (ie 75 units equine antitoxin or 12.5 IU human antitoxin). Second, participants will be randomized with sham procedure
Hospital for Tropical Diseases, Ho Chi Minh City
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
OTHER
Oxford University Clinical Research Unit, Vietnam
OTHER