A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)

PHASE3CompletedINTERVENTIONAL
Enrollment

505

Participants

Timeline

Start Date

March 4, 2017

Primary Completion Date

September 8, 2021

Study Completion Date

December 6, 2024

Conditions
Non Small Cell Lung Cancer
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

DRUG

Cisplatin

Specified dose on specified days

DRUG

Vinorelbine

Specified dose on specified days

DRUG

Gemcitabine

Specified dose on specified days

DRUG

Docetaxel

Specified dose on specified days

DRUG

Pemetrexed

Specified dose on specified days

DRUG

Carboplatin

Specified dose on specified days

DRUG

Paclitaxel

Specified dose on specified days

BIOLOGICAL

Ipilimumab

This arm is closed and no longer enrolling patients.

Trial Locations (140)

112

Local Institution - 0100, Taipei

235

Local Institution - 0102, New Taipei City

1125

Local Institution, Budapest

1181

Local Institution - 0023, Ciudad Autonoma de Buenos Aire

1426

Local Institution - 0022, Capital Federal

8000

Local Institution, Székesfehérvár

10016

Local Institution - 0011, New York

11031

Local Institution - 0099, Taipei

11527

Local Institution - 0019, Athens

12208

Local Institution - 0027, Albany

13915

Local Institution - 0059, Marseille

15212

Local Institution - 0018, Pittsburgh

16132

Local Institution - 0080, Genova

19111

Local Institution - 0010, Philadelphia

21237

Local Institution - 0151, Baltimore

21287

Local Institution - 0001, Baltimore

22031

Local Institution - 0125, Fairfax

22408

Local Institution - 0198, Fredericksburg

27262

Local Institution - 0140, High Point

28041

Local Institution - 0029, Madrid

28222

Local Institution - 0031, Majadahonda - Madrid

29414

Local Institution - 0013, Charleston

29425

Local Institution - 0021, Charleston

29607

Local Institution - 0146, Greenville

30060

Northwest Georgia Oncology Center, P.C., Marietta

31059

Local Institution - 0058, Toulouse

32804

Local Institution - 0054, Orlando

32806

Orlando Health, Inc., Orlando

32960

Indian River Medical Center, Vero Beach

33021

Local Institution - 0173, Hollywood

33136

Local Institution - 0136, Miami

34098

Local Institution - 0115, Istanbul

35033

Local Institution - 0061, Rennes

37044

Local Institution - 0062, Tours

37203

Local Institution - 0092, Nashville

37232

Local Institution - 0005, Nashville

39401

Local Institution - 0090, Hattiesburg

40202

Local Institution - 0186, Louisville

40536

Local Institution - 0170, Lexington

43701

Local Institution - 0149, Zanesville

44109

MetroHealth Medical Center, Cleveland

45219

Christ Hospital, Cincinnati

46804

Local Institution - 0171, Fort Wayne

48121

Local Institution - 0066, Ravenna

49267

Local Institution - 0097, Busan

57001

Local Institution - 0122, Thessaloniki

58128

Local Institution - 0098, Hwasun

59102

St Vincent Frontier Cancer Center, Billings

60611

Local Institution - 0015, Chicago

60637

Local Institution - 0002, Chicago

60714

Illinois Cancer Specialists, Niles

67100

Local Institution - 0113, Strasbourg

69495

Local Institution - 0064, Pierre Benite Cedax

70112

University Medical Center New Orleans, New Orleans

70124

Local Institution - 0068, Bari

75018

Local Institution - 0060, Paris

75248

Local Institution - 0112, Paris

75701

Local Institution - 0143, Tyler

76022

Texas Oncology, Bedford

76712

Local Institution - 0026, Waco

77090

Local Institution - 0106, Houston

78745

Local Institution - 0035, Austin

79415

Southwest Cancer Center, Lubbock

79918

Local Institution - 0153, Fort Bliss

80218

Local Institution - 0025, Denver

84107

Intermountain Medical Center, Murray

84112

Local Institution - 0003, Salt Lake City

84770

Southwest Regional Cancer Clinic, St. George

85308

Local Institution - 0121, Glendale

89128

Local Institution - 0032, Las Vegas

90017

Local Institution - 0081, Los Angeles

97227

Kaiser Permanente, Portland

97239

Local Institution - 0139, Portland

100142

Local Institution - 0161, Beijing

100730

Local Institution, Beijing

100853

Local Institution - 0156, Beijing

130012

Local Institution, Changchun

200030

Local Institution - 0165, Shanghai

200032

Local Institution - 0160, Shanghai

200347

Local Institution - 0050, Craiova

300060

Local Institution - 0163, Tianjin

310003

Local Institution - 0189, Hangzhou

310016

Local Institution - 0183, Hangzhou

310022

Local Institution - 0182, Hangzhou

330006

Local Institution - 0179, Nanchang

330200

Local Institution - 0166, Nanchang

400015

Local Institution - 0051, Romania

407219

Local Institution - 0107, Taichung

410008

Local Institution - 0192, Changsha

410013

Local Institution - 0175, Changsha

Local Institution - 0193, Changsha

510095

Local Institution - 0190, Guangzhou

610041

Local Institution - 0178, Chengdu

710038

Local Institution - 0180, Xi'an

710061

Local Institution - 0159, Xi'an

1138431

Local Institution - 0126, Bunkyo-ku

1600023

Local Institution - 0120, Shinjuku-ku

2418515

Local Institution - 0123, Yokohama

2778577

Local Institution - 0118, Kashiwa-shi

4118777

Local Institution - 0132, Sunto-gun

4640021

Local Institution - 0131, Nagoya

5418567

Local Institution - 0127, Osaka

5918555

Local Institution - 0119, Sakai-shi

6500047

Local Institution - 0133, Kobe

7348551

Local Institution - 0109, Hiroshima

8078555

Local Institution - 0111, Kitakyushu-shi

9601295

Local Institution - 0110, Fukushima

9800873

Local Institution - 0148, Sendai

06062

Local Institution - 0007, Plainville

02215

Local Institution - 0008, Boston

02719

Southcoast Center For Cancer, Fairhaven

02459

Local Institution - 0006, Newton

48202-2608

Local Institution - 0012, Detroit

07601

Local Institution - 0009, Hackensack

07675

Valley Hospital Luckow Pavili, Westwood

75090-0504

Texas Cancer Center - Sherman, Sherman

05405

Local Institution - 0135, Burlington

70200-730

Local Institution - 0079, Brasília

30130-090

Local Institution - 0077, Belo Horizonte

98700-000

Local Institution - 0076, Ijuí

90610-000

Local Institution - 0073, Porto Alegre

14784-400

Fundacao Pio Xii Hosp Cancer De Barretos, Barretos

22793-080

Local Institution - 0075, Rio de Janeiro

J8P 7H2

Local Institution - 0095, Gatineau

H2X 0A9

Local Institution - 0138, Montreal

H4A 3J1

Local Institution - 0017, Montreal

G8Z 3R9

Local Institution - 0052, Trois-Rivières

S7N 4H4

Local Institution - 0016, Saskatoon

06129

Local Institution - 0070, Perugia

00149

Local Institution - 0067, Roma

0030804

Local Institution - 0147, Sapporo

589-8511

Local Institution - 0108, Osaka

113-8603

Local Institution - 0124, Tokyo

1066 CX

Local Institution - 0042, Amsterdam

9700RB

Local Institution - 0043, Groningen

022328

Local Institution - 0069, Sector 2

08308

Local Institution - 0105, Seoul

08035

Local Institution - 0028, Barcelona

01060

Local Institution - 0093, Adana

06100

Local Institution - 0084, Ankara

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY

NCT02998528 - A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter