NCT02996695 - Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

April 6, 2017

Primary Completion Date

June 22, 2018

Study Completion Date

June 22, 2018

Conditions

Plasmodium Falciparum Infection

Interventions

DRUG

Artesunate

Artesunate is a succinic ester of artemether.

DRUG

Chloroquine

4-aminoquinolone, antimalarial agent for oral administration

BIOLOGICAL

PfSPZ (NF54) Challenge

Cryopreserved Plasmodium falciparum (Pf) fully infectious sporozoites (SPZ) that have been developed to be used to infect volunteers in controlled human malaria infection (CHMI) to assess the efficacy of antimalarial drugs and vaccines. The PfSPZ (NF54) Challenge contains a laboratory malaria strain isolated from a Dutch traveler to Africa.

OTHER

Placebo

Trial Locations (1)

Unknown

University of Bamako - Epidemiology of Parasitic Diseases - Malaria Research and Training Center, Sikasso

All Listed Sponsors

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH