Bilateral Transversus Abdominis Plane Block With Exparel Verus Continuous Epidural Analgesia With Bupivacaine

NACompletedINTERVENTIONAL
Enrollment

514

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

June 30, 2019

Study Completion Date

October 31, 2019

Conditions
Pain, PostoperativeMajor Abdominal Surgery
Interventions
PROCEDURE

TAP block

Transversus Abdominis Plane (TAP) blocks will be performed preoperatively. An in-plane ultrasound will be used in TAP block procedure.

PROCEDURE

Epidural analgesia

Epidural catheters will be inserted preoperatively.

DRUG

EXPAREL

Once the target area is positioned, plain bupivacaine 0.25%, 20ml will be given to open the space and then single dose (10ml) of liposomal bupivacaine (Exparel) mixed with saline (10 ml) will be injected in each side. Total dose of Exparel will be 20 mL.

DRUG

Bupivacaine

Once an epidural catheter is successfully positioned, an infusion will be initiated intraoperatively. Bupivacaine standard solution without additives will be prepared for each patient in epidural group.

Trial Locations (2)

44195

Cleveland Clinic Foundation, Cleveland

The Cleveland Clinic Foundation, Cleveland

All Listed Sponsors
lead

The Cleveland Clinic

OTHER

NCT02996227 - Bilateral Transversus Abdominis Plane Block With Exparel Verus Continuous Epidural Analgesia With Bupivacaine | Biotech Hunter | Biotech Hunter