A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma

PHASE3CompletedINTERVENTIONAL
Enrollment

1,134

Participants

Timeline

Start Date

December 31, 2016

Primary Completion Date

March 31, 2020

Study Completion Date

March 31, 2020

Conditions
Carcinoma, Pancreatic Ductal
Interventions
DRUG

Napabucasin

Napabucasin will be administered orally, twice daily, with doses separated by approximately 12 hours.

DRUG

Nab-paclitaxel

Nab-paclitaxel 125 mg/m\^2 immediately followed by gemcitabine 1000 mg/m\^2 will be administered on Days 1, 8 and 15 of every 28-day cycle via intravenous infusion.

DRUG

Gemcitabine

Nab-paclitaxel 125 mg/m\^2 immediately followed by gemcitabine 1000 mg/m\^2 will be administered on Days 1, 8 and 15 of every 28-day cycle via intravenous infusion.

Trial Locations (267)

333

LinKou Chang Gung Memorial Hospital, Taoyuan District

404

China Medical University Hospital, Taichung

833

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

1070

UZ Brussel, Jette

1090

Medical University Vienna, Vienna

2031

Prince of Wales Private Hospital, Randwick

2076

Sydney Adventist Hospital, Wahroonga

2109

Border Medical Oncology, East Albury

Macquarie University Hospital, Sydney

Macquarie University Hospital, Sydney

2148

Blacktown Cancer and Haematology Centre, Blacktown

2485

The Tweed Hospital, Tweed Heads

2640

Border Medical Oncology, East Albury

3000

UZ Leuven, Leuven

3084

The Austin Hospital, Heidelberg

3144

Cabrini Hospital, Malvern

Cabrini Hospital, Malvern

4000

CHU de Liege, Liège

4101

ICON Cancer Care, South Brisbane

ICON Cancer Care, South Brisbane

5020

Universitatsklinik far Innere Medizin III, Salzburg

5530

CHU Dinant Godinne, Yvoir

6009

Sir Charles Gairdner Hospital, Nedlands

6020

Landeskrankenhaus Medical University Innsbruck, Innsbruck

6830

Landeskrankenhaus Feldkirch, Rankweil

8036

LKH Universitätsklinikum Graz, Graz

9000

UZ Ghent, Ghent

10021

Weill Cornell Medicine/ NewYork-Presbyterian, New York

10060

Istituto Ricerca e la Cura del Cancro (IRCC), Candiolo

10126

Dermatological Hospital San Lazzaro, Torino

10467

Montefiore Cancer Center, The Bronx

11042

Clinical Research Alliance, Lake Success

11217

Taipei Veterans General Hospital, Taipei

11733

North Shore Hematology Oncology Associates PC, East Setauket

11794

Stony Brook University, Stony Brook

13057

Hematology Oncology Associates of Central New York, East Syracuse

13326

Basset Medical Center, Cooperstown

13620

Seoul national University Bundang Hospital, Gyeonggi-do

14642

University of Rochester Medical Center, Rochester

15212

Allegheny General Hospital, Pittsburgh

17033

Penn State Milton S. Hershey Medical Center, Hershey

19713

Helen F. Graham Cancer Center, Newark

20007

Georgetown University Medical Center (GUMC), Washington D.C.

20132

IRCCS Ospedale San Raffaele, Milan

21100

ASST Settelaghi, Varese

21204

Greater Baltimore Medical Center, Baltimore

23226

Virginia Cancer Institute, Richmond

24014

Oncology and Hematology Associates of Southwest Virginia, Roanoke

25124

Fondazione Poliambulanza, Brescia

25601

Onkologicke oddeleni, Benešov

26133

Klinikum Oldenburg AöR - UK für Innere Medizin, Oldenburg

26506

West Virginia University Mary Babb Randolph Cancer Center (MBRCC), Morgantown

27157

Wake Forest Baptist Hospital, Winston-Salem

27403

Cone Health Cancer Center, Greensboro

27534

Southeastern Medical Oncology Center, Goldsboro

27599

UNC Chapel Hill / Lineberger Comprehensive Cancer, Chapel Hill

28007

Hospital Universitario Gregorio Marañón, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

Centro Integral Oncologico Clara Campal, Madrid

28220

Hospital Universitario Puerta de Hierro, Madrid

28374

FirstHealth Outpatient Cancer Center, Pinehurst

28922

Hospital Universitario Fundacion Alcorcon, Madrid

29010

Hospital Regional Universitario de Málaga, Málaga

29414

Charleston Hematology Oncology Associates, Charleston

29615

GHS Cancer Institute, Greenville

30322

Winship Cancer Institute of Emory University, Atlanta

30607

University Cancer & Blood Center, Athens

30625

Medizinische Hochschule, Hanover

31904

Columbus Regional Research Institute, Columbus

32032

Santa Maria de Prato Hospital, Feltre

32224

Mayo Clinic Cancer Center, Jacksonville

32256

Cancer Specialists of North Florida, Jacksonville

32806

UF Health Cancer Center - Orlando Health, Orlando

33021

Memorial Regional Hospital, Hollywood

33136

Sylvester Comprehensive Cancer Center, Miami

33140

Mount Sinai Medical Center, Miami Beach

33414

Florida Cancer Specialists East Region, Wellington

33705

Florida Cancer Specialists North, St. Petersburg

33916

Florida Cancer Specialists & Research Institute, Fort Myers

35042

Centre Eugene Marquis, Rennes

35294

UAB Comprehensive Cancer Center, Birmingham

35805

Clearview Cancer Institute (CCI), Huntsville

37170

Hôpital Trousseau, CHRU de Tours, Chambray-lès-Tours

37404

Tennessee Oncology Chattanooga, Chattanooga

37920

University of Tennessee Medical Center, Knoxville

39202

Jackson Oncology Associates, Jackson

40202

Norton Cancer Institute, Louisville

42123

IRCCS Azienda Ospedaliera S.Maria Nuova, Reggio Emilia

44093

CHU-Hôtel Dieu, Nantes

44718

Gabrail Cancer Center (GCC) - Canton Facility, Canton

46202

Indiana University - Melvin and Bren Simon Cancer, Indianapolis

46845

Parkview Physician Group (PPG), Fort Wayne

47014

IRCCS - Studio e la Cura dei Tumori, Meldola

47923

Ospedale degli Infermi, Rimini

48018

Ospedale degli Infermi, Faenza

48334

Barbara Ann Karmanos Cancer Institute, Detroit

50005

Fakultni nemocnice Hradec Kralove, Hradec Králové

53127

University Hospital Bonn, Bonn

54301

HSHS St. Vincent Hospital Regional Cancer Center, Green Bay

54303

Green Bay Oncology, Ltd. - West Green Bay, Green Bay

54519

Institute de Cancerologie de Lorraine, Vandœuvre-lès-Nancy

55416

Metro MN Clinical Oncology Research Consortium, Saint Louis Park

55805

St. Luke's Hospital of Duluth, Duluth

55905

Mayo Clinic, Rochester

57105

Avera Medical Group, Sioux Falls

58128

Chonnam National University Hwasun Hospital, Jeongnam

59102

St. Vincent Frontier Cancer Center, Billings

60201

NorthShore University Health Systems, Evanston

60426

Ingalls Cancer Research Center, Harvey

60488

Krankenhaus Nordwest, Frankfurt am Main

61005

Zaytsev Institute General and Urgent Surgery of National Academy Medical Science of Ukraine, Kharkiv

61801

Carle Cancer Center CCOP, Urbana

62500

Fakultni nemocnice Brno Interni hematoonkologicka klinika, Brno

64111

Saint Luke's Hospital, Kansas City

64132

HCA Midwest Division (Kansas City), Kansas City

65212

University of Missouri - Ellis Fischel Cancer Cent, Columbia

65804

Mercy Clinic - Cancer & Hematology, Springfield

66606

Cotton O'Neil Cancer Center, Topeka

67000

Clinique Saint Anne, Strasbourg

67091

Hopital Civil de strasbourg, Strasbourg

67214

Cancer Center of Kansas, Wichita

68114

Nebraska Methodist Hospital, Omaha

68167

Universitätsmedizin Mannheim, Mannheim

69437

Hopital Edourard Herriot, Lyon

70809

Louisiana Hematology Oncology Associates (LHOA), Baton Rouge

72703

Highlands Oncology Group, Fayetteville

73120

Mercy Clinic Oncology and Hematology - McAuley, Oklahoma City

73505

Cancer Center of Southwest Oklahoma, Lawton

74078

SLK-Kliniken Heilbronn GmbH, Heilbronn

75015

Hopital Europeen Georges Pompidou, Paris

76104

The Center for Cancer and Blood Disorders, Fort Worth

77030

Baylor College of Medicine, Houston

77906

University Hospital Olomouc, Olomouc

80054

Hôpital Sud - CHU Amiens Picardie, Amiens

81925

Klinikum Bogenhausen, München

83706

Saint Alphonsus Health System, Boise

85054

Mayo Clinic, Phoenix

85234

Banner MD Anderson Cancer Center, Gilbert

86021

Poitiers University Hospital, Poitiers

87131

UNM Cancer Research and Treatment Center, Albuquerque

87401

San Juan Oncology Associates, Farmington

88200

AOU Mater Domini, Catanzaro

90017

Los Angeles Hematology Oncology Medical Group, Los Angeles

90033

University of Southern California, Los Angeles

90277

Torrance Health Association DBA Torrance Memorial, Redondo Beach

92224

Gesundheitszentrum St. Marien GmbH, Amberg

92868

St. Joseph Hospital of Orange, Orange

93309

Comprehensive Blood and Cancer Center, Bakersfield

95817

UC Davis, Sacramento

97120

OHSU Knight Cancer Institute, Portland

98201

The Everett Clinic, Everett

98405

MultiCare Institute for Research and Innovation, Tacoma

100142

Beijing Cancer Hospital, Beijing

100853

Chinese PLA General Hospital, Beijing

115478

N.N. Blokhin Russian Cancer Research Center, Moscow

130021

Jilin Cancer Hospital, Changchun

The first hospital of jilin university, Changchun

150000

Harbin Medical University Cancer Hospital, Harbin

163046

Arkhangelsk Regional Clinical Oncology Dispensary, Arkhangelsk

169610

National Cancer Centre Singapore, Singapore

197022

St.Petersburg Medical Universitet n.a. I.P. Pavlov, Saint Petersburg

197758

"FSBI Russian Research Centre of Radiology and Surgical Technologies", Saint Petersburg

198255

City Clinical Oncology Dispensary, Saint Petersburg

200032

Fudan University Shanghai Cancer Center, Shanghai

200040

Huashan Hospital, Shanghai

200120

Ren Ji Hospital Shanghai Jiaotong University School of Medicine, Shanghai

200123

East Hospital of Tongji University, Shanghai

210002

The 81 Hospital of the Chinese Peoples Liberation Army, Nanjing

210009

Jiangsu Cancer Hospital, Nanjing

215006

The First Affiliated Hospital of Soochow University, Suzhou

230022

The First Affiliated Hospital of Anhui Medical University, Hefei

230601

The Second Affiliated Hospital of Anhui Medical University, Hefei

266061

The Affiliated Hospital of Qingdao University, Qingdao

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

305524

Kursk Regional Clinical Oncology Dispensary, Kislino

308433

Tan Tock Seng Hospital, Singapore

310003

The First Affiliated Hospital Zhejiang University, Hangzhou

310009

The Second Affiliated Hospital Zhejiang University, Hangzhou

310016

Sir Run Shaw Hospital School of Medicine Zhejiang University, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

357502

Pyatigorsk Oncology Dispensary, Pyatigorsk

420029

Republic Clinical Oncology Dispensary, Kazan'

428020

Republican Clinical Oncology Dispensary, Cheboksary

430032

National Research Mordovia State University, Saransk

443011

Multi-type clinic 'REAVIZ', Samara

450008

Henan Cancer Hospital, Zhengzhou

454087

Llc Evimed, Chelyabinsk

454091

Railway Clinical Hospital on station Chelyabinsk, Chelyabinsk

460021

Orenburg Regional Clinical Oncology Dispensary, Orenburg

510095

Cancer Center of Guangzhou Medical University, Guangzhou

510180

Guangdong General Hospital, Guangzhou

603006

Privolzhsk District Medical Center, Nizhny Novgorod

644013

Budgetary Healthcare Institution of Omsk Region, Omsk

710061

The First Affiliated Hospital of Xian Jiao Tong University, Xi'an

750004

General Hospital of Ningxia Medical University, Yinchuan

90404-2125

UCLA Medical Center Santa Monica Hematology And Oncology, Santa Monica

94589-2441

Kaiser Permanente - Vallejo Medical Center, Vallejo

06850-3852

Norwalk Hospital The C Anthony and Jean Whittingham Cancer Center, Norwalk

The C Anthony and Jean Whittingham Cancer Center, Norwalk

60555-3269

Northwestern Medicine Regional Medical Group, Warrenville

04074-7171

Maine Center for Cancer Medicine - Scarborough, Scarborough

01655

UMass Memorial Medical Center, Worcester

63110-1032

Washington University School of Medicine, St Louis

07631

Englewood Hospital and Medical Center, Englewood

43623-3536

Toledo Clinic Cancer Centers, Toledo

97124-5806

Kaiser Permanente - Westside Medical Office, Hillsboro

19111-2434

Fox Chase Cancer Center (FCCC) - Philadelphia, Philadelphia

29425-8900

Medical University of South Carolina (MUSC), Charleston

29607-5253

Saint Francis Cancer Center, Greenville

37203-1625

SCRI - Tennessee Oncology, Nashville

23114-3203

Bon Secours Cancer Institute Medical Oncology, Midlothian

53215-4330

Aurora St. Luke's Medical Center - Vince Lombardi, Milwaukee

13-1070

ULB Erasme, Brussels

B-2650

Antwerp University Hospital, Edegem

E3B 5N5

Dr. Everett Chalmers Regional Hospital, Fredericton

B3H 1C2

The Atlantic Clinical Cancer Research Unit (ACCRU), Halifax

H9R 2Y2

Centre Hospitalier de St. Mary, Pointe-Claire

G8Z 3R9

Ciusssmcq, Trois-Rivières

T6G 1Z2

Cross Cancer Institute, Edmonton

M5B 1W8

University of Toronto - St. Michael's Hospital, Toronto

762 75

Onkologické oddělení, Zlín

06100

Centre Antoine Lacassagne, Nice

09116

Klinikum Chemnitz, Chemnitz

06132

AO SM Misericordia, Perugia

464-8681

Aichi Cancer Center Hospital, Nagoya

791-0280

Shikoku Cancer Center, Matsuyama

060-8648

Hokkaido University Hospital, Sapporo

241-8515

Kanagawa Cancer Center, Yokohama

320-0834

Tochigi Cancer Center, Utsunomiya

113-8655

University of Tokyo Hospital, Bunkyō-Ku

104-0045

National Cancer Center Hospital, Chuo-ku

135-8550

The Cancer Institute Hospital Of JFCR, Koto-Ku

181-8611

Kyorin University Hopsital, Mitaka

606-8507

Kyoto University Hospital, Kyoto

541-8567

Osaka International Cancer Institute, Osaka

362-0806

Saitama Cancer Center, Saitama

411-8777

Shizuoka Cancer Center, Shizuoka

8934 AD

Medisch Centrum Leeuwarden (MCL), Leeuwarden

6162 BG

Zuyderland Medical Center, Sittard

3584 CX

University Medical Center Utrecht, Utrecht

8025 AB

Isala Ziekenhuis, Zwolle

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

44-101

Centrum Onkologii-Instytut im.M.Sklodowskiej-Curie, Gliwice

62-500

Przychodnia Lekarska KOMED, Konin

20-081

Klinika Chirurgii Onkologicznej, Lublin

20-090

Centrum Onkologii Ziemi Lubelskiej, Lublin

44-400

Samodzielny Publiczny Szpital Kliniczny, Poznan

87-100

Wojewodzki Szpital Zespolony, Torun

1400-038

Fundação Champalimaud, Lisbon

1500-650

Hospital da Luz, Lisbon

1649-035

Centro Hospitalar Lisboa Norte, Lisbon

4099-001

Centro Hospitalar do Porto, E.P.E, Porto

4200-072

IPO Porto Francisco Gentil, E.P.E., Porto

4520-211

Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

Seoul St. Mary's Hospital, Seoul

08308

Korea University Guro Hospital, Seoul

08035

Hospital Vall d´Hebron, Barcelona

08036

Hospital Clínico y Provincial de Barcelona, Barcelona

08916

(ICO) Hospital Duran i Reynals, Barcelona

Hospital Universitario Germans Trias i Pujol, Barcelona

03022

National Institute of Cancer, Kyiv

All Listed Sponsors
lead

Sumitomo Pharma America, Inc.

INDUSTRY

NCT02993731 - A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma | Biotech Hunter | Biotech Hunter