Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 17, 2017

Primary Completion Date

November 15, 2017

Study Completion Date

November 15, 2017

Conditions
Total Knee ArthroplastyPain, PostoperativeAdductor Canal Block
Interventions
PROCEDURE

Multimodal Peripheral Nerve Block Injection

After successful placement of the adductor canal catheter placed in standard fashion , the patient will receive a one-time 20 ml bolus of 0.25% bupivacaine, 1.67 mcg/ml of clonidine, and 1:400,000 epinephrine followed by a continuous infusion of 0.125% bupivacaine set at 10ml/hour.

PROCEDURE

Single Shot Adductor Canal Block

A total of 20 ml of solution containing a combination of 0.25% bupivacaine, 1.67 mcg/ml of clonidine, 150 micrograms of buprenorphine, 2 mg of dexamethasone, and 1:400,000 epinephrine will be administered underneath the Sartorius muscle. A sham catheter will then be placed subcutaneously into the Sartorius muscle, secured in typical fashion, and connected to a pump containing saline to provide similar shape and weight with an opaque bag covering the pump. The pump will be run at the lowest possible ml/hour rate, which is currently 0.1 ml/hour with the current pump used in our hospital.

DRUG

Initial Bolus

20 ml bolus of 0.25% bupivacaine, 1.67 mcg/ml of clonidine, and 1:400,000 epinephrine

DRUG

Continuous infusion

Continuous infusion of 0.125% bupivacaine

Trial Locations (1)

27157

Wake Forest Baptist Hospital, Winston-Salem

All Listed Sponsors
lead

Wake Forest University Health Sciences

OTHER

NCT02991404 - Single Injection Adductor Canal Block Versus Continuous Adductor Canal Infusion for Total Knee Arthroplasty | Biotech Hunter | Biotech Hunter