Phase Ib/II Trial of Interleukin-2 and PD-1 Checkpoint Inhibitor, Nivolumab In Metastatic Clear Cell Renal Cell Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

March 16, 2017

Primary Completion Date

February 25, 2019

Study Completion Date

June 23, 2020

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Interleukin-2

600,000 IU/kg/dose intravenously during two 5-day cycles 9 days apart

DRUG

Nivolumab

Nivolumab will be administered intravenously at 240 mg/dose over 60 minutes every 14 days, starting 1 week to 3 weeks after the start date of the first cycle of IL2 and continued for up to 48 weeks total in the absence of disease progression

Trial Locations (4)

43210

Ohio State University, Columbus

44106

University Hospitals Seidman Cancer Center, Cleveland

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

55455

University of Minnesota, Minneapolis

All Listed Sponsors
lead

University of Michigan Rogel Cancer Center

OTHER

NCT02989714 - Phase Ib/II Trial of Interleukin-2 and PD-1 Checkpoint Inhibitor, Nivolumab In Metastatic Clear Cell Renal Cell Cancer | Biotech Hunter | Biotech Hunter