NCT02987985View on ClinicalTrials.gov

Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy

PHASE3CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

October 15, 2017

Primary Completion Date

September 20, 2019

Study Completion Date

December 20, 2020

Conditions
AnesthesiaGeneral AnesthesiaAnalgesics, OpioidPostoperative ComplicationsPathologic ProcessesPhysiologic Effects of DrugsNarcoticsAnalgesicsSleep Disordered BreathingObstructive Sleep Apnea of ChildTonsillectomyRespiratory DepressionDexmedetomidineKetamineLidocaineGabapentinPulse Oximetry
Interventions
DRUG

Acetaminophen, gabapentin

acetaminophen 15 mg/kg, gabapentin 10 mg/kg

DRUG

Acetaminophen

acetaminophen 15 mg/kg

DRUG

Ketamine , Lidocaine , Dexmedetomidine

Ketamine 0.5 mg/kg, Lidocaine 1 mg/kg, Dexmedetomidine 0.3 mcg/kg

DRUG

Fentanyl, Dexmedetomidine

Fentanyl 0.5 mcg/kg, Dexmedetomidine 0.3 mcg/kg

DRUG

Dexamethasone , Ondansetron

Dexamethasone 150 mcg/kg, Ondansetron 50 mg/kg

DRUG

Sevoflurane

Sevoflurane (dose titrated to effect)

DRUG

Sevoflurane, Fentanyl

Sevoflurane (dose titrated to effect), Fentanyl as needed (dose at anesthesiologist's discretion)

Trial Locations (1)

S7N 0W8

Royal University Hospital, Saskatoon

All Listed Sponsors
lead

University of Saskatchewan

OTHER

NCT02987985 - Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy | Biotech Hunter | Biotech Hunter