Study of Olaparib (Lynparza™) Versus Enzalutamide or Abiraterone Acetate in Men With Metastatic Castration-Resistant Prostate Cancer (PROfound Study)

PHASE3CompletedINTERVENTIONAL
Enrollment

387

Participants

Timeline

Start Date

February 6, 2017

Primary Completion Date

June 4, 2019

Study Completion Date

February 15, 2023

Conditions
Metastatic Castration-resistant Prostate Cancer
Interventions
DRUG

olaparib

300 mg (2x 150 mg tablets) twice daily

DRUG

enzalutamide

160 mg (4 x 40 mg capsules) once daily

DRUG

abiraterone acetate

1,000 mg (4 x 250 mg tablets) once daily

DRUG

abiraterone acetate

1,000 mg (2 x 500 mg tablets) once daily

DRUG

enzalutamide

160 mg (4 x 40 mg tablets) once daily

Trial Locations (204)

112

Research Site, Taipei

333

Research Site, Taoyuan

404

Research Site, Taichung

807

Research Site, Kaohsiung City

833

Research Site, Kaohsiung City

1020

Research Site, Vienna

1090

Research Site, Vienna

1426

Research Site, Buenos Aires

2000

Research Site, Rosario

2031

Research Site, Randwick

2109

Research Site, Macquarie University

2298

Research Site, Waratah

3000

Research Site, Melbourne

3128

Research Site, Box Hill

3168

Research Site, Clayton

4020

Research Site, Linz

4029

Research Site, Herston

4120

Research Site, Greenslopes

5000

Research Site, Adelaide

Research Site, Odense C

5020

Research Site, Salzburg

5300

Research Site, La Rioja

6009

Research Site, Nedlands

8036

Research Site, Graz

10002

Research Site, Taipei

10408

Research Site, Goyang-si

10468

Research Site, The Bronx

11201

Research Site, Brooklyn

12208

Research Site, Albany

13055

Research Site, Berlin

13210

Research Site, Syracuse

13273

Research Site, Marseille

14000

Research Site, Caen

17007

Research Site, Girona

20007

Research Site, Washington D.C.

20133

Research Site, Milan

20141

Research Site, Milan

21204

Research Site, Towson

21287

Research Site, Baltimore

22030

Research Site, Edirne

22399

Research Site, Hamburg

25030

Research Site, Besançon

25100

Research Site, Brescia

26003

Research Site, Wheeling

27710

Research Site, Durham

28040

Research Site, Madrid

28041

Research Site, Madrid

28144

Research Site, Salisbury

28277

Research Site, Bremen

29010

Research Site, Málaga

29401

Research Site, Charleston

29572

Research Site, Myrtle Beach

30318

Research Site, Atlanta

31096

Research Site, Haifa

31100

Research Site, Toulouse

33000

Research Site, Bordeaux

33011

Research Site, Oviedo

33612

Research Site, Tampa

34030

Research Site, Istanbul

34298

Research Site, Montpellier

34365

Research Site, Istanbul

35575

Research Site, Karşıyaka

37232

Research Site, Nashville

37603

Research Site, Holzminden

38100

Research Site, Trento

38138

Research Site, Germantown

39120

Research Site, Magdeburg

40225

Research Site, Düsseldorf

40705

Research Site, Taichung

41009

Research Site, Seville

41124

Research Site, Modena

41404

Research Site, Daegu

42109

Research Site, Wuppertal

43230

Research Site, Columbus

44805

Research Site, Saint-Herblain

47014

Research Site, Meldola

47130

Research Site, Jeffersonville

47179

Research Site, Duisburg

49241

Research Site, Busan

50006

Research Site, Changhua

50968

Research Site, Cologne

51465

Research Site, Bergisch Gladbach

52100

Research Site, Arezzo

54519

Research Site, Vandœuvre-lès-Nancy

59020

Research Site, Lille

60126

Research Site, Ancona

60611

Research Site, Chicago

61469

Research Site, Gwangju

68130

Research Site, Omaha

69008

Research Site, Lyon

69120

Research Site, Heidelberg

70112

Research Site, New Orleans

70124

Research Site, Bari

70300

Research Site, Ẕerifin

70403

Research Site, Tainan City

72076

Research Site, Tübingen

72622

Research Site, Nürtingen

73104

Research Site, Oklahoma City

75014

Research Site, Paris

78229

Research Site, San Antonio

80131

Research Site, Napoli

84112

Research Site, Salt Lake City

84148

Research Site, Salt Lake City

85704

Research Site, Tucson

85741

Research Site, Tucson

86021

Research Site, Poitiers

89135

Research Site, Las Vegas

90491

Research Site, Nuremberg

91010

Research Site, Duarte

91120

Research Site, Jerusalem

92161

Research Site, San Diego

93105

Research Site, Santa Barbara

94805

Research Site, Villejuif

95847

Research Site, Kfar Saba

97062

Research Site, Tualatin

97477

Research Site, Springfield

99202

Research Site, Spokane

99503

Research Site, Anchorage

4941492

Research Site, Petah Tikva

5265601

Research Site, Ramat Gan

C1118AAT

Research Site, Buenos Aires

C1120AAT

Research Site, Buenos Aires

C1280AEB

Research Site, CABA

14784-400

Research Site, Barretos

30110-022

Research Site, Belo Horizonte

80530-010

Research Site, Curitiba

88034-000

Research Site, Florianópolis

99010-080

Research Site, Passo Fundo

90160-093

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

50040-000

Research Site, Recife

14015-140

Research Site, Ribeirão Preto

22793-080

Research Site, Rio de Janeiro

09060-650

Research Site, Santo André

15090-000

Research Site, São José do Rio Preto

01321-001

Research Site, São Paulo

03102-002

Research Site, São Paulo

T6G 1Z2

Research Site, Edmonton

V1Y 5L3

Research Site, Kelowna

V5Z 4E6

Research Site, Vancouver

L8V 5C2

Research Site, Hamilton

L6H 3P1

Research Site, Oakville

M4N 3M5

Research Site, Toronto

M5G 2M9

Research Site, Toronto

G7H 5H6

Research Site, Chicoutimi

H2X 3E4

Research Site, Montreal

H4A 3J1

Research Site, Montreal

G1J 1Z4

Research Site, Québec

S7N 4H4

Research Site, Saskatoon

07747

Research Site, Jena

113-8431

Research Site, Bunkyō City

113-8510

Research Site, Bunkyō City

113-8603

Research Site, Bunkyō City

812-8582

Research Site, Fukuoka

036-8563

Research Site, Hirosaki-shi

920-8641

Research Site, Kanazawa

634-8522

Research Site, Kashihara-shi

277-8577

Research Site, Kashiwa

350-8550

Research Site, Kawagoe-shi

761-0793

Research Site, Kita-gun

135-8550

Research Site, Kōtoku

606-8507

Research Site, Kyoto

371-8811

Research Site, Maebashi

791-0280

Research Site, Matsuyama

105-8471

Research Site, Minatoku

181-8611

Research Site, Mitaka-shi

889-1692

Research Site, Miyazaki

852-8501

Research Site, Nagasaki

464-8681

Research Site, Nagoya

466-8560

Research Site, Nagoya

541-8567

Research Site, Osaka

545-8586

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

252-0375

Research Site, Sagamihara-shi

285-8741

Research Site, Sakura-shi

060-8648

Research Site, Sapporo

160-8582

Research Site, Shinjuku-ku

565-0871

Research Site, Suita-shi

411-8777

Research Site, Sunto-gun

232-0024

Research Site, Yokohama

1066 CX

Research Site, Amsterdam

1213 XZ

Research Site, Hilversum

2333 ZA

Research Site, Leiden

6525 GA

Research Site, Nijmegen

5042 AD

Research Site, Tilburg

8025 AB

Research Site, Zwolle

N-1478

Research Site, Lørenskog

03722

Research Site, Seoul

05505

Research Site, Seoul

06273

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

08035

Research Site, Madrid

413 45

Research Site, Gothenburg

171 64

Research Site, Solna

01120

Research Site, Adana

06230

Research Site, Ankara

06340

Research Site, Ankara

06590

Research Site, Ankara

EC1M 6BQ

Research Site, London

NW1 2PG

Research Site, London

M20 4BX

Research Site, Manchester

RM7 0BE

Research Site, Romford

SM25PT

Research Site, Sutton

Sponsors
All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Foundation Medicine

INDUSTRY

collaborator

Myriad Genetics, Inc.

INDUSTRY

lead

AstraZeneca

INDUSTRY