116
Participants
Start Date
December 22, 2016
Primary Completion Date
May 22, 2022
Study Completion Date
November 22, 2022
Leflunomide(LEF)
"Leflunomide:~For LEF arm, 20mg per day, p.o. through the whole study. For placebo group, 20mg per day, p.o. from week 25 to week 52."
Prednisone Acetate Tablets
Prednisone (5mg/tab): basic therapy, start with 0.6mg/kg/d and maintained for 4 weeks, then reducing 5mg every 2 weeks until 10mg per day.
Placebos
2 tabs/d used in placebo arm for the first 24 weeks.
Zhongshan hospital, Fudan University, Shanghai
Beijing Anzhen Hospital, Beijing
The first affiliated hospital of Nanchang University, Nanchang
The First Hospital of China Medical University, Shenyang
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Ürümqi
Jiang lindi
OTHER