80
Participants
Start Date
June 19, 2017
Primary Completion Date
March 31, 2026
Study Completion Date
March 31, 2026
Asparaginase Erwinia chrysanthemi
Given Asparaginase Erwinia chrysanthemi
Biospecimen Collection
Undergo blood sample collection
Bone Marrow Aspiration and Biopsy
Undergo a bone marrow aspiration and biopsy
Calaspargase Pegol
Given IV
Cyclophosphamide
Given IV
Cytarabine
Given IV or SC
Diagnostic Imaging
Undergo imaging
Inotuzumab Ozogamicin
Given IV
Leucovorin Calcium
Given PO or IV
Lumbar Puncture
Undergo lumbar puncture
Methotrexate
Given IT
Pegaspargase
Given IV or IM
Vincristine
Given IV
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
Mount Sinai Hospital, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
ACTIVE_NOT_RECRUITING
New York Medical College, Valhalla
RECRUITING
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
RECRUITING
Maimonides Medical Center, Brooklyn
RECRUITING
NYU Langone Hospital - Long Island, Mineola
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Albany Medical Center, Albany
RECRUITING
State University of New York Upstate Medical University, Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
ACTIVE_NOT_RECRUITING
University of Rochester, Rochester
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Penn State Children's Hospital, Hershey
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Saint Christopher's Hospital for Children, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
ACTIVE_NOT_RECRUITING
National Institutes of Health Clinical Center, Bethesda
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
Inova Fairfax Hospital, Falls Church
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
West Virginia University Healthcare, Morgantown
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
ACTIVE_NOT_RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Duke University Medical Center, Durham
RECRUITING
East Carolina University, Greenville
RECRUITING
Mission Hospital, Asheville
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Memorial Health University Medical Center, Savannah
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
ACTIVE_NOT_RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
AdventHealth Orlando, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Nicklaus Children's Hospital, Miami
RECRUITING
Saint Mary's Medical Center, West Palm Beach
RECRUITING
Tampa General Hospital, Tampa
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
ACTIVE_NOT_RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
RECRUITING
Children's Hospital of Alabama, Birmingham
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
T C Thompson Children's Hospital, Chattanooga
RECRUITING
East Tennessee Childrens Hospital, Knoxville
RECRUITING
Saint Jude Children's Research Hospital, Memphis
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
ACTIVE_NOT_RECRUITING
Cleveland Clinic Foundation, Cleveland
RECRUITING
Children's Hospital Medical Center of Akron, Akron
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Dayton Children's Hospital, Dayton
RECRUITING
Riley Hospital for Children, Indianapolis
ACTIVE_NOT_RECRUITING
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
RECRUITING
Corewell Health Children's, Royal Oak
RECRUITING
C S Mott Children's Hospital, Ann Arbor
ACTIVE_NOT_RECRUITING
Michigan State University, East Lansing
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Blank Children's Hospital, Des Moines
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
ACTIVE_NOT_RECRUITING
Children's Hospital of Wisconsin, Milwaukee
ACTIVE_NOT_RECRUITING
Marshfield Medical Center-Marshfield, Marshfield
RECRUITING
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
RECRUITING
University of Minnesota/Masonic Cancer Center, Minneapolis
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Loyola University Medical Center, Maywood
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Saint Jude Midwest Affiliate, Peoria
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Cardinal Glennon Children's Medical Center, St Louis
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
University of Missouri Children's Hospital, Columbia
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Medical City Dallas Hospital, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Cook Children's Medical Center, Fort Worth
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Driscoll Children's Hospital, Corpus Christi
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
Covenant Children's Hospital, Lubbock
RECRUITING
UMC Cancer Center / UMC Health System, Lubbock
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
Phoenix Childrens Hospital, Phoenix
RECRUITING
Banner Children's at Desert, Mesa
ACTIVE_NOT_RECRUITING
Banner University Medical Center - Tucson, Tucson
RECRUITING
Sunrise Hospital and Medical Center, Las Vegas
RECRUITING
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
RECRUITING
Summerlin Hospital Medical Center, Las Vegas
RECRUITING
Renown Regional Medical Center, Reno
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
Cedars Sinai Medical Center, Los Angeles
RECRUITING
Kaiser Permanente Downey Medical Center, Downey
ACTIVE_NOT_RECRUITING
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
ACTIVE_NOT_RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
ACTIVE_NOT_RECRUITING
Rady Children's Hospital - San Diego, San Diego
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Children's Hospital of Orange County, Orange
ACTIVE_NOT_RECRUITING
Valley Children's Hospital, Madera
RECRUITING
UCSF Medical Center-Mission Bay, San Francisco
RECRUITING
Lucile Packard Children's Hospital Stanford University, Palo Alto
RECRUITING
UCSF Benioff Children's Hospital Oakland, Oakland
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Sutter Medical Center Sacramento, Sacramento
ACTIVE_NOT_RECRUITING
University of California Davis Comprehensive Cancer Center, Sacramento
RECRUITING
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
Legacy Emanuel Children's Hospital, Portland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Providence Alaska Medical Center, Anchorage
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Connecticut Children's Medical Center, Hartford
ACTIVE_NOT_RECRUITING
Yale University, New Haven
RECRUITING
Eastern Maine Medical Center, Bangor
RECRUITING
Maine Children's Cancer Program, Scarborough
ACTIVE_NOT_RECRUITING
Tufts Children's Hospital, Boston
RECRUITING
Dana-Farber Cancer Institute, Boston
RECRUITING
UMass Memorial Medical Center - University Campus, Worcester
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Morristown Medical Center, Morristown
RECRUITING
Saint Peter's University Hospital, New Brunswick
RECRUITING
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
RECRUITING
Newark Beth Israel Medical Center, Newark
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
Rhode Island Hospital, Providence
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
University of Vermont and State Agricultural College, Burlington
ACTIVE_NOT_RECRUITING
HIMA San Pablo Oncologic Hospital, Caguas
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK