NCT02978625View on ClinicalTrials.gov

Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

68

Participants

Timeline

Start Date

September 27, 2017

Primary Completion Date

September 1, 2027

Study Completion Date

September 1, 2027

Conditions
Anaplastic Large Cell Lymphoma, ALK-NegativeAnaplastic Large Cell Lymphoma, ALK-PositiveApocrine CarcinomaCarcinoma Arising From CylindromaCarcinoma Arising From SpiradenomaDigital Papillary AdenocarcinomaEndocrine Mucin-Producing Sweat Gland CarcinomaExtramammary Paget DiseaseExtraocular Sebaceous CarcinomaHidradenocarcinomaMalignant Sweat Gland NeoplasmMerkel Cell CarcinomaMicrocystic Adnexal CarcinomaNK-Cell Lymphoma, UnclassifiablePapillary AdenocarcinomaPorocarcinomaPrimary Cutaneous Mucinous CarcinomaRecurrent Mature T-Cell and NK-Cell Non-Hodgkin LymphomaRecurrent T-Cell Non-Hodgkin LymphomaRefractory Anaplastic Large Cell LymphomaRefractory Mature T-Cell and NK-Cell Non-Hodgkin LymphomaRefractory Merkel Cell CarcinomaRefractory Mycosis FungoidesRefractory Primary Cutaneous T-Cell Non-Hodgkin LymphomaRefractory Skin Squamous Cell CarcinomaRefractory T-Cell Non-Hodgkin LymphomaSezary SyndromeSignet Ring Cell AdenocarcinomaSkin Adenoid Cystic CarcinomaSkin Adnexal CarcinomaSkin Basal Cell CarcinomaSkin Basosquamous Cell CarcinomaSkin KeratoacanthomaSkin Squamous Cell CarcinomaSquamoid Eccrine Ductal CarcinomaSquamous Cell Carcinoma of Unknown PrimarySweat Gland CarcinomaTrichilemmal CarcinomaVulvar Squamous Cell Carcinoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT

OTHER

Laboratory Biomarker Analysis

Correlative studies

BIOLOGICAL

Nivolumab

Given IV

PROCEDURE

Positron Emission Mammography

Undergo PET/CT

BIOLOGICAL

Talimogene Laherparepvec

Given IT

Trial Locations (36)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

14263

Roswell Park Cancer Institute, Buffalo

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

60611

Northwestern University, Chicago

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66205

University of Kansas Clinical Research Center, Fairway

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

68198

University of Nebraska Medical Center, Omaha

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

80045

UCHealth University of Colorado Hospital, Aurora

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91105

Keck Medical Center of USC Pasadena, Pasadena

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

University of California Davis Comprehensive Cancer Center, Sacramento

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH