A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

PHASE3CompletedINTERVENTIONAL
Enrollment

405

Participants

Timeline

Start Date

June 13, 2017

Primary Completion Date

August 25, 2022

Study Completion Date

August 8, 2024

Conditions
Metastatic Castration Resistant Prostate Cancer
Interventions
DRUG

Rucaparib

Rucaparib will be administered daily.

DRUG

Abiraterone acetate or Enzalutamide or Docetaxel

Abiraterone acetate and enzalutamide will be administered daily. Docetaxel will be administered every 3 weeks.

Trial Locations (150)

2020

ZNA Middelheim, Antwerp

2065

Northern Cancer Insitute, St. Leonards, Saint Leonards

2100

Copenhagen University Hospital, Copenhagen

2228

Southside Cancer Care Centre, Miranda

2650

Riverina Cancer Care Centre, Wagga Wagga

2730

Herlev Hospital, Herlev

2800

Orange Health Service, Orange

3199

Peninsula & Southeast Oncology, Frankston

3220

Barwon Health, University Hospital Geelong, Geelong

4000

CHU Sart-Tilman, Liège

5000

Clinique et Maternité Sainte-Elisabeth, Namur

6008

St John of God Hospital, Subiaco, Subiaco

6423

The Tel Aviv Sourasky Medical Center (Ichilov Hospital), Tel Aviv

7000

Royal Hobart Hospital, Hobart

7100

Vejle Sygehus, Vejle

8500

AZ Groeninge, Kortrijk

10016

NYU Perlmutter Cancer Center, New York

10065

Memorial Sloan Kettering CC, New York

Weill Cornell Medical College, New York

12200

Charite - Universitaetsmedizin Berlin, Berlin

12601

Premier Medical Group of the Hudson Valley PC, Poughkeepsie

13210

SUNY Upstate Medical University, Syracuse

14004

Hospital Universitario Reina Sofia, Córdoba

14263

Roswell Park, Buffalo

14642

University of Rochester, Rochester

19002

Hospital General Universitario de Guadalajara, Guadalajara

19713

Medical Oncology Hematology Consultants - USOR, Newark

20141

IEO Instituto Europeo di Oncologia, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf (UKE), Hamburg

20889

Walter Reed National Military Medical Center, Bethesda

21044

Maryland Oncology Hematology P.A., Columbia

21079

Centre Georges François Leclerc, Dijon

21201

University of Maryland Greenebaum Cancer Center, Baltimore

22190

Centre Armoricain de Radiotherapie, Imagerie medicale et Oncologie, CARIO, Plérin

23462

Urology of Virginia, Virginia Beach

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

27004

Hospital Universitario Lucus Augusti., Lugo

27599

University of North Carolina Lineberger Cancer Center, Chapel Hill

27705

Durham VA Medical Center, Durham

28025

Carolina Urology Partners, Concord

28033

MD Anderson Cancer Center - Madrid, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28041

Hospital 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

29010

Hospital Clinico Universitario Virgen de la Victoria, Málaga

30312

Atlanta Urological Group, Atlanta

32806

University of Florida Health Cancer Center, Orlando

33011

Hospital Universitario Central de Asturias, Oviedo

33486

Boca Raton Community Hospital, Inc., Boca Raton

35042

CRLCC Eugene Marquis, Rennes

35233

University of Alabama at Birmingham, Birmingham

37209

Urology Associates Clinical Research, Nashville

38102

Apotheke des Städtischen Klinikums Braunschweig, Braunschweig

38122

Presidio Ospedaliero Santa Chiara di Trento, Trento

39008

Marques de Valdecilla University Hospital (HUMV), Santander

40225

Universitatsklinikum Dusseldorf, Düsseldorf

41013

Hospital Universitario Virgen del Rocío, Seville

41124

University of Modena and Reggio Emilia, Modena

42103

Die GesundheitsUnion (DGU), Wuppertal

44130

Clinical Research Solutions, Middleburg Heights

45211

Oncology Hematology Care, Cincinnati

45212

The Urology Group, Cincinnati

45429

Kettering Medical Center, Kettering

46009

Instituto Valenciano de Oncología, Valencia

47014

Romagnolo per lo Studio e la Cura dei Tumori IRST-IRCCS - Oncologia medica, Meldola

48018

Ospedale Santa Maria delle Croci, Faenza

48105

VA Ann Arbor Healthcare System, Ann Arbor

48202

Henry Ford Hospital, Detroit

50937

Universitätsklinikum Köln, Cologne

52100

Ospedale San Donato, Azienda USLSUDEST, Arezzo

54000

Polyclinique de Gentilly (Centre D'Oncologie De Gentilly), Nancy

55404

Minnesota Oncology Hematology, P.A., Minneapolis

55417

Minnesota Veterans Research Institute, Minneapolis

55455

University of Minnesota, Minneapolis

55902

Mayo Clinic - Rochester, MN, Rochester

59000

Hôpital Privé La Louvière, Lille

68130

Alegent Health Bergan Mercy Hospital , GU Research Network, Omaha

Nebraska Cancer Specialists, Omaha

68167

Medizinischen Fakultät Mannheim der Universität Heidelberg, Mannheim

69008

Centre Léon Bérard, Lyon

70121

Ochsner Medical Center, New Orleans

72000

Clinique Victor Hugo Centre Jean Bernard, Le Mans

72076

University of Tuebingen, Tübingen

72622

Studienpraxis Urologie, Nürtingen

75231

Urology Clinics of North Texas, Dallas

75248

Institut Curie, Paris

75390

UT Southwestern Medical Center, Dallas

77030

UT Health Science Center, Houston

78681

Texas Oncology Cancer Center-Round Rock, Round Rock

79312

Urologische Gemeinschaftspraxis, Emmendingen

80012

Rocky Mountain Cancer Centers, Aurora

85054

Mayo Clinic - Arizona, Phoenix

85704

Arizona Oncology Associates - USOR, Tucson

86150

Gemeinschaftspraxis für Hämatologie&Onkologie, Augsburg

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90073

VA Greater Los Angeles Healthcare System, Los Angeles

90210

University of Southern California, Beverly Hills

91120

Hadassah University Hospital, Jerusalem

92123

Sharp Memorial Hospital, San Diego

92404

San Bernardino Urological Associates, San Bernardino

92653

Alliance Research Centers, Laguna Hills

94115

Pacific Hematology Oncology Associates, San Francisco

94121

San Francisco VA Health Care System, San Francisco

94158

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94589

Kaiser Permanente, Northern CA, Vallejo

94805

Institut Gustave-Roussy, Villejuif

95403

St. Joseph Heritage Healthcare, Santa Rosa

96819

Kaiser Permanente Medical Group, Honolulu

97219

VA Portland Health Care System, Portland

97227

Northwest Cancer Specialist DBA Compass Oncology, Portland

97239

Knight Cancer Institute, Portland

98108

VA Puget Sound HCS, Seattle

98109

University of Washington Fred Hutchinson Cancer Research Center, Seattle

98335

MultiCare Regional Cancer Center - Gig Harbor, Gig Harbor

3109601

Rambam Health Care Campus (RHCC), Rambam Medical Center, Haifa

4428164

Meir Medical Center, Kfar Saba

4941492

Rabin Medical Center-Beilinson Campus, Petah Tikva

5262000

Chaim Sheba Medical Center, Tel Litwinsky

06510

Yale University School of Medicine, New Haven

02114

Massachusetts General Hospital, Boston

08648

Premier Urology Associates, Lawrenceville

T2N 4N2

Tom Baker Cancer Centre, Calgary

R3E 0V9

Cancer Care Manitoba, Winnipeg

E1C 8X3

Centre Hospitalier Universitaire Dr-Georges-L.-Dumont, Moncton

N6A 4L6

London Health Sciences Centre, London

K1H8L6

The Ottawa Hospital, Ottawa

M5G 2M9

Princess Margaret Cancer Centre, Toronto

L1G 2B9

Lakeridge Health Medical Specialty Medical Oncology, Oshawa

M4N3M5

Sunnybrook Odette Cancer Centre, Toronto

01307

University Hospital Carl Gustav Carus, Dresden

07747

Universitatsklinikum Jena, Jena

Unknown

Cork University Hospital, Cork

Adelaide & Meath Hospital, Incorporating the National Children's Hospital, Dublin

Mater Misericordiae University Hospital, Dublin

Mater Private Hospital (MPH), Dublin

St James's Hospital, Dublin

St. Vincent's University Hospital, Dublin

00152

Azienda Ospedaliera San Camillo-Forlanini, Roma

05100

Azienda Opsedaliera S. Maria di Terni, Terni

08916

Hospital Universitari Germans Trias i Pujol, Barcelona

08208

Corporacio Sanitaria Parc Tauli, Sabadell

SE1 9RT

Guy's and St Thomas' NHS Foundation Trust, London

SM2 5PT

Royal Marsden Hospital, London

Royal Marsden Hospital, London

OX3 7LE

Oxford Cancer Centre, Medical Oncology Unit, Oxford

PR2 9HT

Royal Preston Hospital, Preston

SL2 4HL

Wexham Park Hospital, Slough

CF14 2TL

Velindre Hospital, Cardiff

CH63 4JY

The Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral

TA15DA

Musgrove Park Hospital, Taunton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Foundation Medicine

INDUSTRY

lead

pharmaand GmbH

INDUSTRY