A Study of BR Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated MCL

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

635

Participants

Timeline

Start Date

April 5, 2017

Primary Completion Date

October 28, 2025

Study Completion Date

October 28, 2025

Conditions
Lymphoma, Mantle Cell
Interventions
DRUG

Acalabrutinib

Administered orally (PO)

DRUG

Bendamustine

Administered intravenously (IV)

DRUG

Rituximab

Administered intravenously (IV)

DRUG

Placebo

Placebo comparator

Trial Locations (228)

1

Research Site, Lima

34

Research Site, Lima

100

Research Site, Taipei

123

Research Site, Hanoi

333

Research Site, Taoyuan District

833

Research Site, Kaohsiung City

1023

Research Site, Grafton

1085

Research Site, Budapest

1122

Research Site, Budapest

1640

Research Site, Otahuhu

2060

Research Site, Antwerp

2139

Research Site, Concord

2250

Research Site, Gosford

2298

Research Site, Newcastle

2990

Research Site, Mexico City

3000

Research Site, Leuven

3022

Research Site, Kiev

3080

Research Site, Seoul

3084

Research Site, Heidelberg

3199

Research Site, Frankston

3722

Research Site, Seoul

4032

Research Site, Debrecen

4102

Research Site, Woolloongabba

4215

Research Site, Southport

5000

Research Site, Córdoba

5042

Research Site, Bedford Park

5154

Research Site, Arequipa

5403

Research Site, São Paulo

5505

Research Site, Seoul

6009

Research Site, Nedlands

6150

Research Site, Murdoch

6351

Research Site, Seoul

6591

Research Site, Seoul

6725

Research Site, Szeged

7624

Research Site, Pécs

7985

Research Site, Seoul

8003

Research Site, Barcelona

8035

Research Site, Barcelona

8900

Research Site, Roeselare

8907

Research Site, Barcelona

8916

Research Site, Badalona

9000

Research Site, Ghent

9016

Research Site, Dunedin

9024

Research Site, Győr

9100

Research Site, Sint-Niklaas

10002

Research Site, Zhytomyr

10126

Research Site, Turin

10532

Research Site, Hawthorne

11042

Research Site, Lake Success

11525

Research Site, Athens

13620

Research Site, Gyeonggi-do

14029

Research Site, Chernihiv

14080

Research Site, México

18009

Research Site, Cherkasy

20007

Research Site, Washington D.C.

20089

Research Site, Rozzano

20132

Research Site, Milan

20162

Research Site, Milan

22060

Research Site, Fort Belvoir

22908

Research Site, Charlottesville

24019

Research Site, Périgueux

26504

Research Site, Pátrai

26506

Research Site, Morgantown

27100

Research Site, Pavia

28007

Research Site, Madrid

28040

Research Site, Madrid

28046

Research Site, Madrid

28222

Research Site, Majadahonda

29425

Research Site, Charleston

29615

Research Site, Greenville

30060

Research Site, Marietta

31008

Research Site, Pamplona

31096

Research Site, Haifa

33401

Research Site, West Palm Beach

33604

Research Site, Pessac

35000

Research Site, Rennes

37203

Research Site, Nashville

37404

Research Site, Chattanooga

40138

Research Site, Bologna

40207

Research Site, Louisville

40447

Research Site, Taichung

42123

Research Site, Reggio Emilia

46026

Research Site, Valencia

48109

Research Site, Ann Arbor

48149

Research Site, Münster

49102

Research Site, Dnipropetrovsk

49201

Research Site, Busan

50012

Research Site, Brasov

63110

Research Site, St Louis

64132

Research Site, Kansas City

64239

Research Site, Tel Aviv

66205

Research Site, Westwood

75702

Research Site, Tyler

76090

Research Site, Querétaro

77030

Research Site, Houston

78217

Research Site, San Antonio

79044

Research Site, Lviv

85719

Research Site, Tucson

87042

Research Site, Limoges

88212

Research Site, Ravensburg

89081

Research Site, Ulm

90146

Research Site, Palermo

90241

Research Site, Downey

90404

Research Site, Santa Monica

93000

Research Site, Bobigny

95100

Research Site, Argenteuil

97239

Research Site, Portland

98108

Research Site, Seattle

98109

Research Site, Seattle

98122

Research Site, Seattle

100036

Research Site, Beijing

100050

Research Site, Xicheng District

100191

Research Site, Haidian District

116023

Research Site, Dalian

130021

Research Site, Changchun

150081

Research Site, Harbin

167029

Research Site, Syktyvkar

197022

Research Site, Saint Petersburg

197341

Research Site, Saint Petersburg

200032

Research Site, Xuhui District

210029

Research Site, Nanjing

215006

Research Site, Suzhou

221000

Research Site, Xuzhou

266100

Research Site, Qingdao

300020

Research Site, Tianjian

300053

Research Site, Tula

310022

Research Site, Gongshu District

325000

Research Site, Wenzhou

330006

Research Site, Nanchang

330029

Research Site, Nanchang

357532

Research Site, Pyatigorsk

400037

Research Site, Chongqing

400124

Research Site, Cluj-Napoca

410008

Research Site, Changsha

410013

Research Site, Changsha

430030

Research Site, Wuhan

430079

Research Site, Wuhan

450000

Research Site, Zhengzhou

450008

Research Site, Zhengzhou

494142

Research Site, Petah Tikva

610041

Research Site, Wuhou District

700000

Research Site, Ho Chi Minh City

700483

Research Site, Iași

999077

Research Site, Hong Kong

1236030

Research Site, São Paulo

9103102

Research Site, Jerusalem

06510

Research Site, New Haven

32308-5304

Research Site, Tallahassee

55905-0001

Research Site, Rochester

07601

Research Site, Hackensack

07960

Research Site, Morristown

C1114AAP

Research Site, Buenos Aires

C1426ANZ

Research Site, Buenos Aires

C1430EGF

Research Site, Buenos Aires

C1431FWO

Research Site, Buenos Aires

C1118AAT

Research Site, Caba

QLD, 4029

Research Site, Herston

NSW 2217

Research Site, Kogarah

NSW 2145

Research Site, Sydney

01321-001

Research Site, Bela Vista

81520-060

Research Site, Curitiba

90035-903

Research Site, Porto Alegre

RS 90610-000

Research Site, Porto Alegre

20231-050

Research Site, Rio de Janeiro

41253-190

Research Site, Salvador

01232-010

Research Site, São Paulo

05652-9000

Research Site, São Paulo

08270-070

Research Site, So Paulo

V5Z 4E6

Research Site, Vancouver

L1G 2B9,

Research Site, Oshawa

M4N 3M5

Research Site, Toronto

T6G 1Z2

Research Site, Edmonton

J4V 2H1

Research Site, Greenfield Park

NS B3H 2Y9

Research Site, Halifax

Unknown

Research Site, Shanghai

Research Site, Shenyang

Research Site, Tianjin

Research Site, Pok Fu Lam

Research Site, Parma

Research Site, Monterrey

Research Site, Bellavista

Research Site, Saint Petersburg

Research Site, Seville

Research Site, Hanoi

625 00

Research Site, Brno

500 05, CZ

Research Site, Hradec Králové

708 52

Research Site, Ostrava Poruba

30460, CZ

Research Site, Pilsen

100 34, CZ

Research Site, Prague

33076, FR

Research Site, Bordeaux

72000, FR

Research Site, Le Mans

86000, FR

Research Site, Vienne

69120, DE

Research Site, Heidelberg

81377, DE

Research Site, München

52064, DE

Research Site, Nordrhein-Westfalen

55131, DE

Research Site, Rheinland-Pfalz

11527, GR

Research Site, Athens

11528, GR

Research Site, Athens

45500, GR

Research Site, Ioannina

54007, GR

Research Site, Thessaloniki

57010, GR

Research Site, Thessaloniki

811-1395

Research Site, Fukuoka

812-8582

Research Site, Fukuoka

650-0047

Research Site, Kobe

602-8026

Research Site, Kyoto

791-0280

Research Site, Matsuyama

460-0001

Research Site, Nagoya

464-8681

Research Site, Nagoya

565-0871

Research Site, Osaka

003-0006

Research Site, Sapporo

980-8574

Research Site, Sendai

693-8501

Research Site, Shimane

104-0045

Research Site, Tokyo

135-8550

Research Site, Tokyo

241-8515

Research Site, Yokohama

41-500

Research Site, Chorzów

30-510

Research Site, Krakow

93-510

Research Site, Lodz

20-090

Research Site, Lublin

10-228

Research Site, Olsztyn

02-106

Research Site, Warsaw

02-776

Research Site, Warsaw

04-141

Research Site, Warsaw

36-200

Research Site, Woj. Podkarpackie

50-367

Research Site, Wroclaw

070131

Research Site, Bucharest

08041

Research Site, Barcelona

WARD 7

Research Site, Ho Chi Minh City

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Acerta Pharma BV

INDUSTRY