182
Participants
Start Date
October 1, 2016
Primary Completion Date
September 16, 2021
Study Completion Date
September 19, 2022
N-Acetylcysteine (NAC) Treatment
Participant will receive 12 weeks of Active Treatment NAC (2400 mg) daily. The study medication will be provided in blister packs in the form of 600 mg tablets. Each participant will be asked to take two (2) 600 mg tablets in the morning and two (2) 600 mg tablets in the evening.
Cognitive Behavioral Therapy (CBT)
Participant will receive 12 weeks of weekly cognitive-behavioral therapy, medication management, and AE monitoring.
Inactive Placebo Oral Capsule
Participant will receive 12 weeks of inactive placebo. The study medication will be provided in blister packs in the form of 600 mg tablets. Each participant will be asked to take two (2) 600 mg tablets in the morning and two (2) 600 mg tablets in the evening.
Functional magnetic resonance imaging (fMRI)
Participants will be given the option to complete Functional magnetic resonance imaging (fMRI) at two timepoints (pre-treatment and end of treatment).
Proton magnetic resonance spectroscopy (MRS) Imaging
Participants will be given the option to complete magnetic resonance spectroscopy (MRS) at two timepoints (pre-treatment and end of treatment).
Medical University of South Carolina, Charleston
The Charleston Center, Charleston
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
National Institutes of Health (NIH)
NIH
Medical University of South Carolina
OTHER