Trial Evaluating the Safety of 2 Schedules of Cabazitaxel in Elderly Men With mCRPC Previously Treated With a Docetaxel

PHASE3CompletedINTERVENTIONAL
Enrollment

196

Participants

Timeline

Start Date

May 5, 2017

Primary Completion Date

December 2, 2021

Study Completion Date

December 2, 2021

Conditions
Prostate Cancer Metastatic
Interventions
DRUG

cabazitaxel

"* Arm A : cabazitaxel 25 mg/m² on Day 1 of a 3-week cycle plus daily prednisone or~* Arm B: cabazitaxel 16 mg/m² on Day 1 and Day 15 of a 4-week cycle plus daily prednisone.~* Treatment will be continued for a maximum of 10 cycles unless there is documented disease progression or unacceptable toxicity.~* Standard cabazitaxel premedication will be used"

DRUG

Prednisone

Arm A:plus prednisone 10 mg orally given daily for a maximum of 10 cycles Arm B: plus prednisone 10 mg orally given per day up to 10 cycles

DRUG

Granulocyte colony-stimulating factor (G-CSF)

Primary prophylaxis with Granulocyte Colony-Stimulating Factor (G-CSF) will be injected from Day 3 to Day 7 after every administration of cabazitaxel

Trial Locations (31)

14000

Centre Maurice Tubiana, Caen

22015

Clinique Armoricaine de Radiologie, Saint-Brieuc

25030

Hôpital Jean Minjoz, Besançon

29229

Clinique Pasteur-CFRO, Brest

30029

Institut de Cancérologie du Gard - CHU, Nîmes

33075

Hôpital Saint André, CHU de Bordeaux, Bordeaux

39104

Universitäts-klinik für Urologie und Kinderurologie, Magdeburg

Urologische Praxis am Hasselbachplatz, Magdeburg

48149

Universitätsklinikum Münster, Klinik für Urologie und Kinderurologie,, Münster

50937

Uniklinik Köln, Urologie, Uro-Onkologie, spezielle urologische und Roboter-assistierte Chirurgie, Cologne

51465

Urologie und Kinderurologie Marienkrankenhaus Bergisch, Gladbach

57045

Hôpital Belle-Isle, Metz

59000

Centre Oscar Lambret Lille, Lille

59300

Centre de cancérologie Les Dentellières, Valenciennes

60204

Polyclinique Saint-Côme, Compiègne

67000

Hôpitaux universitaires de Strasbourg, Strasbourg

72000

Clinique Victor Hugo, Le Mans

72622

Studienpraxis Urologie, Nürtingen

75014

Institut Mutualiste Montsouris, Paris

75015

Hôpital Européen Georges Pompidou, Paris

75020

Hôpital Universitaire Tenon, Paris

75679

Hôpital Cochin, Paris

76000

CHU de Rouen, Rouen

86021

CHU de Poitiers, Poitiers

89100

Centre Hospitalier de Sens, Sens

92151

Hôpital FOCH, Suresnes

93370

GHIRM, Montfermeil

94000

CHU Henri-Mondor, Créteil

94160

HIA Bégin 69 avenue de Paris, Saint-Mandé

06406

Urologisch-onkologische Schwerpunktpraxis, Bernburg

Unknown

Universitätsklinikum Hamburg-Eppendorf, Hamburg

All Listed Sponsors
lead

Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie

OTHER

NCT02961257 - Trial Evaluating the Safety of 2 Schedules of Cabazitaxel in Elderly Men With mCRPC Previously Treated With a Docetaxel | Biotech Hunter | Biotech Hunter