742
Participants
Start Date
February 24, 2017
Primary Completion Date
September 28, 2020
Study Completion Date
September 1, 2021
Aripiprazole Augmentation
Augment current antidepressant treatment with aripiprazole (tablets). Start at 2 mg daily; increase every two weeks (i.e., to 5, 7, 10 mg) to a maximum of 15 mg daily based on symptom severity and side effects.
Bupropion Augmentation
Augment current antidepressant treatment with bupropion once-daily extended release, starting at 150 mg daily; titrated after four weeks to 300 mg daily based on symptom severity and side effects.
Switch to bupropion
Taper from current antidepressant therapy. Start bupropion once-daily extended release at 150 mg daily; titrated after four weeks to 300 mg daily based on symptom severity and side effects.
Lithium Augmentation
Augment current antidepressant treatment with lithium carbonate tablets starting at 300 mg daily, titrated per blood level to 0.4-0.6 meQ/L.
Switch to nortriptyline
Taper from current antidepressant therapy. Start on nortriptyline tablets starting at 1 mg per kg of body weight daily, titrated per blood level to 80-120 ng/ml
Columbia University Adult and Late Life Depression Clinic, New York
UPMC Late-Life Depression, Evaluation, Prevention, and Treatment Program, Pittsburgh
Washington University School of Medicine Healthy Mind Lab, St Louis
UCLA Late-Life Mood, Stress, and Wellness Research Program, Los Angeles
Centre for Addiction and Mental Health, Toronto
Patient-Centered Outcomes Research Institute
OTHER
National Institute of Mental Health (NIMH)
NIH
Washington University School of Medicine
OTHER