NCT02954484 - Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty | Biotech Hunter

Enrollment

116

Participants

Timeline

Start Date

April 30, 2015

Primary Completion Date

May 31, 2017

Study Completion Date

May 31, 2017

Conditions

Pain, Postoperative

Interventions

DRUG

pregabalin

see arm/group description. Lyrica manufacture site: Pfizer Manufacturing Deutschland GmbH, Freiburg, Germany.

DRUG

Placebo

Placebo capsule containing lactose and MCC (no active ingredients).

DRUG

Etoricoxib

Etoricoxib 120mg per oral once daily on postoperative days 1,2,3. 'Arcoxia' manufacture site: MSD International GMBH, Singapore

DRUG

paracetamol

Paracetamol 1g per oral 6hourly on postoperative days 1,2,3. Manufacture site: SM Pharmaceuticals, Malaysia

DRUG

Morphine

"patient-controlled analgesia intravenous morphine sulphate on postoperative days 1,2,3.~Manufacture site: Hameln Pharma Plus GMBH, Hameln, Germany"

DRUG

Ropivacaine

Femoral block with ropivacaine 0.5% 30mls. Ropivacaine manufacture site: AstraZeneva AB, Sweden

All Listed Sponsors

lead

National University Hospital, Singapore

OTHER