Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in UC

Oral tacrolimus tablet starting at 0.05mg/kg twice daily, with dose adjustments aiming for serum trough levels of 10-15 ng/ml during the first 2 weeks, and 5-10ng/ml subsequently.

Intravenous Vedolizumab 300 mg at week 0, 2 and 6 followed by the same dose every 8 weeks. This drug will be given as per standard of care.

Patients will be randomized 1:1 in Treatment arm (receive Tacrolimus) and Placebo Arm.