Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)

PHASE3TerminatedINTERVENTIONAL
Enrollment

697

Participants

Timeline

Start Date

November 28, 2016

Primary Completion Date

December 23, 2019

Study Completion Date

August 25, 2020

Conditions
Squamous Cell Carcinoma of the Head and Neck
Interventions
DRUG

Avelumab

Avelumab + SOC Chemoradiation

OTHER

Chemoradiation

Cisplatin + Radiation Therapy

Trial Locations (316)

6

St Luke's Radiation Oncology Network, St Luke's Hospital, Dublin

8

St James's Hospital, Dublin

St. James's Hospital, Dublin

100

National Taiwan University Hospital, Taipei

112

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

333

Chang Gung Memorial Hospital-Linkou Branch, Taoyuan

704

National Cheng Kung University Hospital, Tainan City

1011

Centre Hospitalier Universitaire Vaudois, Lausanne

1090

University Hospital Brussels, Brussels

1122

Orszagos Onkologiai Intezet, B Belgyogyaszati Osztaly, Budapest

Orszagos Onkologiai Intezet, Sugarterapias Osztaly, Budapest

1145

Uzsoki Utcai Korhaz, Budapest

2050

Chris O'Brien Lifehouse Medical Imaging, Camperdown

Chris O'Brien Lifehouse Radiation Oncology Department, Camperdown

Chris O'Brien Lifehouse, Camperdown

2065

Northern Sydney Cancer Centre, St Leonards

2500

Illawarra Shoalhaven Local Health District, Wollongong

2610

GZA Hospitals Campus Sint Augustinus, Wilrijk

3084

Austin Health, Heidelberg

3220

Barwon Health, University Hospital Geelong, Geelong

4031

Klinik fur Radiologie und Nuklearmedizin, Basel

Klinik fur Strahlentherapie und Radioonkologie, Basel

Universitatsspital Basel, Basel

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

5000

Site Sainte Elisabeth / CHU UCL Namur, Namur

6000

Grand Hopital de Charleroi - Site Notre-Dame, Charleroi

6500

Istituto Oncologico della Svizzera Italiana IOSI, Ospedale San Giovanni, Bellinzona

Radiologia ORBV, Ospedale San Giovanni, Bellinzona

6720

Szegedi Tudomanyegyetem, Szent-Gyorgyi Albert Klinikai Kozpont, Szeged

7100

Centre Hospitalier de Jolimont, Haine-Saint-Paul

7624

Pecsi Tudomanyegyetem, Klinikai Kozpont, Onkoterapias Intezet, Pécs

8091

Institut fur Klinische Pathologie, Zurich

Klinik fur Nuklearmedizin, Zurich

Universitatsspital Zurich, Zurich

8401

Kantonsspital Winterthur, Medizinische Onkologie, Winterthur

Kantonsspital Winterthur, Radiologie, Winterthur

Kantonsspital Winterthur, Winterthur

9024

Petz Aladar Megyei Oktato Koraz, Onkoradiologiai osztaly, Győr

10016

Bellevue Hospital Center, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

NYU Langone Medical Center, New York

NYU Langone Radiology, New York

10017

NYU Langone Radiology - Ambulatory Care Center East 41st Street, New York

10022

Memorial Sloan Kettering Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center: Breast and Imaging Center, New York

Memorial Sloan Kettering Cancer Center, New York

10408

Center for Proton Therapy, National Cancer Center, Goyang-si

Center for Specific Organ Cancer, National Cancer Center, Goyang-si

10461

Montefiore-Einstein Center for Cancer Care, The Bronx

10467

Montefiore Medical Center, The Bronx

10604

Memorial Sloan Kettering Cancer Center Westchester, Harrison

11217

Taipei Veterans General Hospital, Taipei

11553

Memorial Sloan Kettering Cancer Center- Nassau, Uniondale

11725

Memorial Sloan Kettering Cancer Center Commack, Commack

11794

Stony Brook Cancer Center, Stony Brook

12462

Attikon University Hospital, Haidari

13125

Helios Klinikum Berlin-Buch, Institut fur Rontgendiagnostik, Berlin

Helios Klinikum Berlin-Buch, Klinik fur Nuklearmedizin, Berlin

Helios Klinikum Berlin-Buch, Klinik fur Strahlentherapie, Berlin

Helios Klinikum Berlin-Buch, Berlin

13496

Department of Radiation Oncology, CHA Bundang Medical Center, CHA University, Seongnam-si

13620

Seoul National University Bundang Hospital, Seongnam-si

14004

Hospital Universitario Reina Sofia, Córdoba

14564

"General Oncology Hospital of Kifissia Agioi Anargiroi", Athens

15232

UPMC Hillman Cancer Center, Pittsburgh

UPMC Shadyside Radiation Oncology, Pittsburgh

17007

Institut Catala D'Oncologia de Girona, Girona

17050

PinnacleHealth Cancer Institute, Jacksville

17109

PinnacleHealth Cancer Institute, Harrisburg

17325

Precision Cancer Research / Gettysburg Cancer Center, Gettysburg

18017

Lehigh Valley Health Network-Muhlenberg, Bethlehem

18103

Lehigh Valley Health Network Cancer Center Pharmacy, Allentown

Lehigh Valley Health Network-Cedar Crest, Allentown

Radiation Oncology Cancer Services, Allentown

19111

Fox Chase Cancer Center, Philadelphia

20014

Hospital Universitario Donostia, Donostia / San Sebastian

21201

Maryland Proton Treatment Center, Baltimore

University of Maryland School of Medicine, Baltimore

University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore

23007

Complejo Hospitalario de Jaen, Jaén

25123

ASST degli Spedali Civili di Brescia, Brescia

27157

Wake Forest Baptist Health, Winston-Salem

28040

Hospital Clinico San Carlos, Madrid

28046

Hospital Universitario La Paz, Madrid

28204

Oncology Specialists of Charlotte, PA, Charlotte

28210

DJL Clinical Research, PLLC, Charlotte

29010

Hospital Virgen de la Victoria, Málaga

29220

Cabinet de radiologie Privé - Dr Joseph Mocaer, Brest

29229

Clinique Pasteur - CFRO, Brest

29307

GHS Cancer Institute, Spartanburg

29403

MUSC- Rutledge Tower, Charleston

29425

Medical University of South Carolina- Hollings Cancer Center, Charleston

MUSC SCTR Research Nexus Clinical Science Building, Charleston

MUSC- Ashley River Tower, Charleston

MUSC- Radiation Oncology, Charleston

MUSC- University Hospital, Charleston

29603

Hospital Costa del Sol, Marbella

29605

GHS Cancer Institute, Greenville

29615

GHS Cancer Institute, Greenville

29640

GHS Cancer Institute, Easley

29650

GHS Cancer Institute, Greer

29672

GHS Cancer Institute, Seneca

30120

Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar

33012

Specialist Global LLC, Hialeah

33021

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

33028

Memorial Cancer Institute at Memorial Hospital West, Pembroke Pines

33075

Hopital Pellegrin - Service de radiologie et d'imagerie, Bordeaux

Hopital Saint-Andre, Bordeaux

33136

Sylvester Comprehensive Cancer Center, Miami

33146

Sylvester at Coral Gables, Coral Gables

33324

Sylvester at Plantation, Plantation

33442

Sylvester at Deerfield Beach, Deerfield Beach

33612

H. Lee Moffitt Cancer Center and Research Institute, Tampa

33805

Hollis Cancer Center, Lakeland

34298

Institut Regional du Cancer Montpellier - Val d'Aurelle, Montpellier

35760

Centre Hospitalier Prive Saint Gregoire, Saint-Grégoire

37007

Hospital Universitario de Salamanca, Salamanca

37045

AULSS 9 - Scaligera Ospedale Mater Salutis, Legnago

37232

Henry-Joyce Cancer Clinic, Nashville

38104

The West Clinic PC dba West Cancer Center, Memphis

38138

The West Clinic, PC dba West Cancer Center, Germantown

40202

Norton Cancer Institute, Louisville

Norton Hospital, Louisville

University Medical Center, Inc., Louisville

40225

Universitatsklinikum Dusseldorf, Düsseldorf

40241

Norton Brownsboro Hospital, Louisville

Norton Cancer Institute, Louisville

40447

China Medical University Hospital, Taichung

40705

Taichung Veterans General Hospital, Taichung

41101

Ashland-Bellefonte Cancer Center, Ashland

41124

AOU Policlinico Di Modena, Modena

41653

Highlands Cancer Center, Prestonsburg

42123

AUSL - IRCCS and Reggio Emilia, Reggio Emilia

42271

Institut de cancerologie de la Loire Lucien Neuwirth, Saint-Priest-en-Jarez

43126

Azienda Ospedaliero-Universitaria di Parma, Parma

44033

Department of Radiation Oncology, Ulsan University Hospital, Ulsan

Ulsan University Hospital, Ulsan

44106

University Hospitals Cleveland Medical Center, Cleveland

44277

Hopital prive du Confluent S.A.S., Nantes

Hopital prive du Confluent S.A.S, Nantes

44805

Institut de Cancerologie de l'Ouest (ICO) - Site Rene Gauducheau, Saint-Herblain

46009

Fundacion Instituto Valenciano de Oncologia, Valencia

47014

Istituto Scientifico Romagnolo per lo studio e la cura dei Tumori (I.R.S.T), Meldola

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola

IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola

47521

Ospedale M. Bufalini, Cesena

47904

IU Health Arnett Cancer Center, Lafayette

48022

UOC Oncologia Medica, AUSL della Romagna -RAVENNA, Lugo

48121

IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Ravenna

UOC Oncologia Medica, AUSL della Romagna - RAVENNA, Ravenna

48201

Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48334

Karmanos Cancer Institute, Farmington Hills

48912

Herbert-Herman Cancer Center, Sparrow Hospital, Lansing

49055

Institut de Cancerologie de l'Ouest (ICO) - Site Paul Papin, Angers

50009

Hospital Clinico Universitario Lozano Blesa, Zaragoza

52621

The Chaim Sheba M.C.Tel-Hashomer, Ramat Gan

54645

Euromedica General Clinic, Thessaloniki

58128

Chonnam National University Hwasun Hospital, Hwasun-gun

60422

Primary Healthcare Associates, Flossmoor

60426

Ingalls Memorial Hospital, Harvey

Primary Healthcare Associates, Harvey

60477

Primary Healthcare Associates, Tinley Park

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine Siteman Cancer Center, St Louis

63129

Siteman Cancer Center - South County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center- St. Peters, City of Saint Peters

64128

Kansas City VA Medical Center, Kansas City

65212

University of Missouri- Ellis Fischel Cancer Center, Columbia

66212

Kansas City VA Radiation Oncology Clinic, Overland Park

67065

Centre Paul Strauss - Radiologie et medecine nucleaire, Strasbourg

67200

ICANS - Institut de cancerologie Strasbourg Europe, Strasbourg

68114

Department of Radiation Oncology Methodist Hospital, Omaha

Oncology Hematology West, PC dba Nebraska Cancer Specialists, Omaha

72703

Highlands Oncology Group, Fayetteville

72758

Highlands Oncology Group, Rogers

72762

Highlands Oncology Group, Springdale

73100

Presidio Ospedaliero Vito Fazzi, Lecce

73104

OU Medical Center, Oklahoma City

Stephenson Cancer Center, Oklahoma City

University of Oklahoma Health Sciences Center- Stephenson Cancer Center, Oklahoma City

75005

Institut Curie, Paris

77030

Memorial Hermann Hospital - TMC, Houston

UTHealth/Memorial Hermann Cancer Center, Houston

77555

University of Texas Medical Branch, Galveston

77573

UTMB Cancer Center at Victory Lakes, League City

79902

Texas Oncology El Paso Cancer Treatment Center, El Paso

79920

William Beaumont Army Medical Center, El Paso

80045

Rocky Mountain Lions Eye Institute, Aurora

University of Colorado Denver CTO/CTRC, Aurora

University of Colorado Hospital - Anschutz Inpatient Pavilion, Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion, Aurora

University Of Colorado Hospital Cancer Center, Aurora

80131

Istituto Nazionale Tumori IRCCS - Fondazione Pascale, Napoli

80138

Cypress Hematology and Oncology, Parker

80210

Cypress Hematology & Oncology, Denver

84106

Utah Cancer Specialists, Salt Lake City

84157

Utah Cancer Specialists, Murray

84918

Institut Sainte Catherine, Avignon

87131

University of New Mexico Comprehensive Cancer Center, Albuquerque

90033

The Oncology Institute of Hope and Innovation, Los Angeles

90048

Cedars Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles

90211

Beverly Hills Cancer Center, Beverly Hills

Tower Hematology Oncology Medical Group, Beverly Hills

90241

The Oncology Institute of Hope and Innovation, Downey

90262

The Oncology Institute of Hope and Innovation, Lynwood

90503

The Oncology Institute of Hope and Innovation, Torrance

90602

The Oncology Institute of Hope and Innovation, Whittier

90640

The Oncology Institute of Hope and Innovation, Montebello

90805

The Oncology Institute of Hope and Innovation, Long Beach

91010

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte

91030

City of Hope South Pasadena, South Pasadena

91120

Hadassah University Hospital, Department of Oncology, Jerusalem

91204

The Oncology Institute of Hope and Innovation, Glendale

91790

The Oncology Institute of Hope and Innovation, West Covina

91914

UCSD Radiation Oncology South Bay, Cancer Treatment Centers, Chula Vista

92037

UC San Diego Medical Center- La Jolla (Thornton Hospital), La Jolla

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center- Hillcrest, San Diego

92200

Clinique Hartmann, Neuilly-sur-Seine

Hopital Americain de Paris, Neuilly-sur-Seine

92309

Hopital Franco-Britannique, Institut d'Oncologie Hauts-de-Seine Nord, Levallois-Perret

92501

Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc., Riverside

92705

The Oncology Institute of Hope and Innovation, Santa Ana

92801

The Oncology Institute of Hope and Innovation, Anaheim

92879

City of Hope Corona, Corona

Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc., Corona

93042

Universitätsklinikum Regensburg, Regensburg

93309

CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center, Bakersfield

93534

City of Hope Antelope Valley, Lancaster

94800

Institut Gustave Roussy, Villejuif

98101

Virginia Mason Medical Center, Seattle

98108

VA Puget Sound Health Care System, Seattle

100142

Beijing Cancer Hospital, Beijing

110042

Liaoning Cancer Hospital & Institute, Shenyang

115478

N. N. Blokhin NMRCO, Moscow

150054

"SBHI YaR Regional Clinical Oncology Hospital", Yaroslavl

150081

Harbin Medical University Cancer Hospital, Harbin

197758

"FSBI National Medical Research Center of Oncology n.a. N.N. Petrov", Saint Petersburg

"SBIH SPb Clinical Research Centre of Specialized Kinds of Medical Care (Oncology)", Saint Petersburg

200032

Fudan University Shanghai Cancer Center, Shanghai

200123

Shanghai East Hospital/Oncology Department, Shanghai

300060

Tianjin Cancer Hospital, Tianjin

350014

Fujian Cancer Hospital, Fuzhou

410008

Xiangya Hospital Central South University/Oncology Department, Changsha

430022

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology/Cancer Center, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

454087

"SBIH Chelyabinsk Regional Clinical Centre of Oncology and Nuclear Medicine", Chelyabinsk

510060

SUN Yat-Sen University Cancer Center, Guangzhou

510095

Cancer Center of Guangzhou Medical University/Oncology Department, Guangzhou

530021

Affiliated Tumor Hospital of Guangxi Medical University, Nanning

570311

Hai Nan General Hospital, Haikou

610041

West China Hospital of Sichuan University, Chengdu

644013

"Budgetary Institution of Healthcare of Omsk Region Clinical Oncology Dispensary", Omsk

1040045

National Cancer Center Hospital, Chuo-ku

3109601

Rambam Health Care Campus, Haifa

4941492

Rabin Medical Center, Petah Tikva

92868-3201

UC Irvine Medical Center, Orange

02215

Dana-Farber Cancer Institute, Boston

07920

Memorial Sloan Kettering Cancer Center-Basking Ridge, Basking Ridge

07601

Hackensack University Medical Center, Hackensack

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

07748

Memorial Sloan Kettering Cancer Center- Monmouth, Middletown

07645

Memorial Sloan Kettering Cancer Center- Bergen, Montvale

11794-7007

Stony Brook University, Stony Brook

79920-5001

William Beaumont Army Medical Center, El Paso

A-4010

Ordensklinikum Linz GmbH, Linz

G1R 2J6

CHU de Quebec - Universite Laval, Québec

06189

Centre Antoine Lacassagne, Nice

07745

Universitatsklinikum Jena, Jena

07747

Universitatsklinikum Jena, Jena

A94 E4X7

Blackrock Clinic, Dublin

464-8681

Aichi cancer center central hospital, Nagoya

466-8560

Nagoya University Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

060-8648

Hokkaido University Hospital, Sapporo

650-0017

Kobe University Hospital, Kobe

981-1293

Miyagi Cancer Center, Natori-shi

980-8574

Tohoku University Hospital, Sendai

541-8567

Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Sayama

362-0806

Saitama Cancer Center, Kita-adachi-gun

411-8777

Shizuoka Cancer Center, Sunto-gun

329-0498

Jichi Medical University Hospital, Shimotsuke

135-8550

Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-ku

85-796

Centrum Onkologii im. prof. F. Lukaszczyka, Bydgoszcz

80-214

Uniwersyteckie Centrum Kliniczne, Gdansk

44-101

Centrum Onkologii - Instytut im. M. Sklodowskiej - Curie, Klinika Radioterapii i Chemioterapii, Gliwice

10-228

SPZOZ Ministerstwa Spraw Wewnetrznych i Administracji z Warminsko-Mazurskim Centrum Onkologii, Olsztyn

97-200

NZOZ Provita Prolife Centrum Medyczne, Tomaszów Mazowiecki

Specjalistyczny Szpital Onkologiczny NU-MED sp. z o.o., Tomaszów Mazowiecki

4464-513

Hospital Pedro Hispano, Matosinhos Municipality

4460-188

CUF Porto, Senhora da Hora

Julio Teixeira, Porto

4434-502

Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia

3000-075

Instituto Portugues de Oncologia de Coimbra Francisco Gentil, E.P.E., Coimbra

4099-001

Centro Hospitalar do Porto, E.P.E.- Hospital de Santo Antonio, Porto

4200-072

Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E., Porto

4200-319

Centro Hospitalar São João, E.P.E, Porto

03080

Division of Radiation Oncology, Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

Division of Radiation Oncology, Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

07061

SMG-SNU Boramae Medical Center, Seoul

08916

Institut Catala d'Oncologia Badalona, Hospital Germans Trias i Pujol, Badalona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

AB25 2ZN

NHS Grampian, Aberdeen

CH63 4JY

The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington

BS2 8ED

University Hospital Bristol NHS Foundation Trust, Bristol

EH4 2XU

NHS Lothian, Western General Hospital, Edinburgh

SE1 9RT

Guy's and St. Thomas' NHS Foundation Trust, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY