120
Participants
Start Date
October 31, 2016
Primary Completion Date
September 30, 2021
Study Completion Date
February 28, 2022
Mediterranean diet
In the Mediterranean diet fat intake will be equal to 35% of the total energy intake minus carbohydrate and protein energy carbohydrate as 65% of total calorie intake, dietary cholesterol \<300 mg/day, dietary fiber 25 g/day.
Low fat diet
In the hypocaloric low fat diet, fat will represent less than 25% of the total energy intake. Branched and essential amino acids will be administered taking into account the total protein intake.
Aerobic exercise
"A personalized program of aerobic exercise will be prescribed to the participants of both arms, following the FITT principles (frequency, intensity, time and type)."
Department of Translational and Precision Medicine, Sapienza University of Rome, Umberto I Hospital, Rome
Bambino Gesù Hospital and Research Institute
OTHER
Università degli studi di Roma Foro Italico
OTHER
Göteborg University
OTHER
University of Roma La Sapienza
OTHER